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AT3G62980.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.526
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : F-box/RNI-like superfamily protein
Curator
Summary (TAIR10)
Encodes an auxin receptor that mediates auxin-regulated transcription. It contains leucine-rich repeats and an F-box and interacts with ASK1, ASK2 and AtCUL1 to form SCF-TIR1, an SCF ubiquitin ligase complex. Related to yeast Grr1p and human SKP2 proteins, involved in ubiquitin-mediated processes. Required for normal response to auxin and repressed in response to flagellin. As part of the SCF complex and in the presence of auxin, TIR1 interacts with Aux/IAA transcriptional repressor proteins and mediates their degradation.
Computational
Description (TAIR10)
TRANSPORT INHIBITOR RESPONSE 1 (TIR1); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364); BEST Arabidopsis thaliana protein match is: GRR1-like protein 1 (TAIR:AT4G03190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioGrid:10787DIP:DIP-31740NeggNOG:ENOG410XQ54eggNOG:KOG1947EMBL:AF005047EMBL:AF005048EMBL:AK220790
EMBL:AL163816EMBL:BT001946EMBL:CP002686EMBL:EF598824EMBL:EF598825EMBL:EF598826EMBL:EF598827
EMBL:EF598828EMBL:EF598829EMBL:EF598830EMBL:EF598831EMBL:EF598832EMBL:EF598833EMBL:EF598834
EMBL:EF598835EMBL:EF598836EMBL:EF598837EMBL:EF598838EMBL:EF598839EMBL:EF598840EMBL:EF598841
EMBL:EF598842EMBL:EF598843EMBL:EF598844EMBL:EF598845EMBL:EF598846EMBL:EF598847EMBL:EU550991
EMBL:EU550992EMBL:EU550993EMBL:EU550994EMBL:EU550995EMBL:EU550996EMBL:EU550997EMBL:EU550998
EMBL:EU550999EMBL:EU551000EMBL:EU551001EMBL:EU551002EMBL:EU551003EMBL:EU551004EMBL:EU551005
EMBL:EU551006EMBL:EU551007EMBL:EU551008EMBL:EU551009EMBL:EU551010EMBL:EU551011EMBL:EU551012
EMBL:EU551013EMBL:EU551014EnsemblPlants:AT3G62980EnsemblPlants:AT3G62980.1entrez:825473EvolutionaryTrace:Q570C0Gene3D:3.80.10.10
GeneID:825473Genevisible:Q570C0GO:GO:0000822GO:GO:0002237GO:GO:0004842GO:GO:0005634GO:GO:0006952
GO:GO:0007049GO:GO:0009733GO:GO:0009734GO:GO:0009873GO:GO:0010011GO:GO:0010152GO:GO:0010311
GO:GO:0016036GO:GO:0019005GO:GO:0038198GO:GO:0048443Gramene:AT3G62980.1hmmpanther:PTHR24006hmmpanther:PTHR24006:SF456
HOGENOM:HOG000239805InParanoid:Q570C0IntAct:Q570C0InterPro:IPR001810InterPro:IPR006553InterPro:IPR032675KEGG:ath:AT3G62980
KO:K14485OMA:CLSGFWDPaxDb:Q570C0PDB:2P1MPDB:2P1NPDB:2P1OPDB:2P1P
PDB:2P1QPDB:3C6NPDB:3C6OPDB:3C6PPDBsum:2P1MPDBsum:2P1NPDBsum:2P1O
PDBsum:2P1PPDBsum:2P1QPDBsum:3C6NPDBsum:3C6OPDBsum:3C6PPfam:PF12937Pfam:Q570C0
PhylomeDB:Q570C0PIR:T48087PRIDE:Q570C0PRO:PR:Q570C0ProteinModelPortal:Q570C0Proteomes:UP000006548RefSeq:NP_567135.1
SMART:SM00256SMART:SM00367SMR:Q570C0STRING:3702.AT3G62980.1SUPFAM:SSF52047SUPFAM:SSF81383TAIR:AT3G62980
tair10-symbols:TIR1UniGene:At.25594UniPathway:UPA00143UniProt:Q570C0
Coordinates (TAIR10) chr3:-:23273479..23276181
Molecular Weight (calculated) 66802.20 Da
IEP (calculated) 7.21
GRAVY (calculated) 0.01
Length 594 amino acids
Sequence (TAIR10)
(BLAST)
001: MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI GNCYAVSPAT VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM
101: SSSYTWLEEI RLKRMVVTDD CLELIAKSFK NFKVLVLSSC EGFSTDGLAA IAATCRNLKE LDLRESDVDD VSGHWLSHFP DTYTSLVSLN ISCLASEVSF
201: SALERLVTRC PNLKSLKLNR AVPLEKLATL LQRAPQLEEL GTGGYTAEVR PDVYSGLSVA LSGCKELRCL SGFWDAVPAY LPAVYSVCSR LTTLNLSYAT
301: VQSYDLVKLL CQCPKLQRLW VLDYIEDAGL EVLASTCKDL RELRVFPSEP FVMEPNVALT EQGLVSVSMG CPKLESVLYF CRQMTNAALI TIARNRPNMT
401: RFRLCIIEPK APDYLTLEPL DIGFGAIVEH CKDLRRLSLS GLLTDKVFEY IGTYAKKMEM LSVAFAGDSD LGMHHVLSGC DSLRKLEIRD CPFGDKALLA
501: NASKLETMRS LWMSSCSVSF GACKLLGQKM PKLNVEVIDE RGAPDSRPES CPVERVFIYR TVAGPRFDMP GFVWNMDQDS TMRFSRQIIT TNGL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)