AT3G50630.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : KIP-related protein 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Gene was isolated from a yeast two hybrid screen as an interacting protein of CDC2A. Recombinant protein has a strong kinase inhibitor activity in vitro. Transcript is expressed in all tissues examined but is differentially distributed from ICK1. Controls the onset of the endoreduplication cycle through inhibition of CDKA;1. The KRP2 protein abundance is regulated by proteolysis through CDKB1;1 phosphorylation. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
KIP-related protein 2 (KRP2); FUNCTIONS IN: protein binding, kinase inhibitor activity, cyclin-dependent protein kinase inhibitor activity; INVOLVED IN: negative regulation of cyclin-dependent protein kinase activity, DNA endoreduplication; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); Has 103 Blast hits to 103 proteins in 17 species: Archae - 0; Bacteria - 0; Metazoa - 2; Fungi - 2; Plants - 97; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:+:18800508..18801366 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 24037.90 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 4.43 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.88 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 209 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MAAVRRRERD VVEENGVTTT TVKRRKMEEE VDLVESRIIL SPCVQATNRG GIVARNSAGA SETSVVIVRR RDSPPVEEQC QIEEEDSSVS CCSTSEEKSK 101: RRIEFVDLEE NNGDDRETET SWIYDDLNKS EESMNMDSSS VAVEDVESRR RLRKSLHETV KEAELEDFFQ VAEKDLRNKL LECSMKYNFD FEKDEPLGGG 201: RYEWVKLNP |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)