AT5G13570.1
Subcellular Consensus
(Prediction and Experimental) min: :max .
SUBAcon:cytosol 1.000 ASURE: cytosol What is SUBAcon? |
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Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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Description (TAIR10) | protein_coding : decapping 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Curator Summary (TAIR10) |
Encodes DCP2 with mRNA decapping activity. DCP2 forms a mRNA decapping complex with DCP1 (At1g08370) and VCS (VARICOSE) (At3g13300). Recombinant DCP2 is enzymatically active in vitro, generating from capped mRNAs m7GDP, and 5’-phosphorylated mRNAs. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP1. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Computational Description (TAIR10) |
decapping 2 (DCP2); CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), Dcp2, box A (InterPro:IPR007722), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 901 Blast hits to 899 proteins in 331 species: Archae - 18; Bacteria - 332; Metazoa - 132; Fungi - 156; Plants - 50; Viruses - 11; Other Eukaryotes - 202 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Protein Annotations |
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Coordinates (TAIR10) | chr5:+:4367532..4369992 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight (calculated) | 42389.30 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IEP (calculated) | 8.07 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GRAVY (calculated) | -0.48 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Length | 373 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence (TAIR10) (BLAST) |
001: MSGLHRSSSS SKNIGNCLPS KELLDDLCSR FVLNVPEEDQ QSFERILFLV EYAYWYYEDN AVENDPKLKS LSLKEFTSLL FNSCDVLRPY VTHIDDIFKD 101: FTSYKCRVPV TGAIILDETY ERCLLVKGWK GSSWSFPRGK KSKDEEDHAC AIREVLEETG FDVSKLLKRE EYIEFVFRQQ RVRLYIVAGV TEDTVFAPLT 201: KKEISEITWH RLDHLQPASN EVITHGVSGL KLYMVAPFLS SLKSWILKHP SPVARRPNKP LKALCVWNAR TSVGGNGTAT VESQNRKSEL RTTTMESNSR 301: KPELKRTTME SHSTKPELRK GTMESHNTTA TVESHNTKPV VDHSQDIKPG GSFINFKFNQ SVILQALESG NSA |
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See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)