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AT4G25540.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : homolog of DNA mismatch repair protein MSH3
Curator
Summary (TAIR10)
encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH3 heterodimers bound 'insertion-deletion' DNA with three nucleotides (+AAG) or one nucleotide (+T) looped out much better than they bound DNA with a base/base mispair (T/G).
Computational
Description (TAIR10)
homolog of DNA mismatch repair protein MSH3 (MSH3); CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 14547 Blast hits to 13713 proteins in 2703 species: Archae - 153; Bacteria - 9793; Metazoa - 705; Fungi - 864; Plants - 451; Viruses - 3; Other Eukaryotes - 2578 (source: NCBI BLink).
Protein Annotations
eggNOG:COG0249eggNOG:KOG0218EMBL:AJ007791EMBL:AL022197
EMBL:CP002687EnsemblPlants:AT4G25540EnsemblPlants:AT4G25540.1entrez:828659
Gene3D:3.30.420.110Gene3D:3.40.1170.10Gene3D:3.40.50.300GeneID:828659
Genevisible:O65607GO:GO:0000404GO:GO:0003684GO:GO:0005524
GO:GO:0005634GO:GO:0006298GO:GO:0030983GO:GO:0043570
Gramene:AT4G25540.1hmmpanther:PTHR11361hmmpanther:PTHR11361:SF34HOGENOM:HOG000029776
InParanoid:O65607InterPro:IPR000432InterPro:IPR007695InterPro:IPR007696
InterPro:IPR007860InterPro:IPR007861InterPro:IPR016151InterPro:IPR027417
iPTMnet:O65607KEGG:ath:AT4G25540KO:K08736ncoils:Coil
OMA:GYLLCITPaxDb:O65607Pfam:O65607Pfam:PF00488
Pfam:PF01624Pfam:PF05188Pfam:PF05190Pfam:PF05192
PhylomeDB:O65607PIR:T05793PIR:T51613PRIDE:O65607
PRO:PR:O65607PROSITE:PS00486ProteinModelPortal:O65607Proteomes:UP000006548
Reactome:R-ATH-5358606RefSeq:NP_194284.2scanprosite:PS00486SMART:SM00533
SMART:SM00534SMR:O65607STRING:3702.AT4G25540.1SUPFAM:SSF48334
SUPFAM:SSF52540SUPFAM:SSF53150SUPFAM:SSF55271TAIR:AT4G25540
tair10-symbols:ATMSH3tair10-symbols:MSH3UniGene:At.506UniProt:O65607
Coordinates (TAIR10) chr4:-:13042700..13048115
Molecular Weight (calculated) 119373.00 Da
IEP (calculated) 7.04
GRAVY (calculated) -0.14
Length 1081 amino acids
Sequence (TAIR10)
(BLAST)
0001: MGKQKQQTIS RFFAPKPKSP THEPNPVAES STPPPKISAT VSFSPSKRKL LSDHLAAASP KKPKLSPHTQ NPVPDPNLHQ RFLQRFLEPS PEEYVPETSS
0101: SRKYTPLEQQ VVELKSKYPD VVLMVEVGYR YRFFGEDAEI AARVLGIYAH MDHNFMTASV PTFRLNFHVR RLVNAGYKIG VVKQTETAAI KSHGANRTGP
0201: FFRGLSALYT KATLEAAEDI SGGCGGEEGF GSQSNFLVCV VDERVKSETL GCGIEMSFDV RVGVVGVEIS TGEVVYEEFN DNFMRSGLEA VILSLSPAEL
0301: LLGQPLSQQT EKFLVAHAGP TSNVRVERAS LDCFSNGNAV DEVISLCEKI SAGNLEDDKE MKLEAAEKGM SCLTVHTIMN MPHLTVQALA LTFCHLKQFG
0401: FERILYQGAS FRSLSSNTEM TLSANTLQQL EVVKNNSDGS ESGSLFHNMN HTLTVYGSRL LRHWVTHPLC DRNLISARLD AVSEISACMG SHSSSQLSSE
0501: LVEEGSERAI VSPEFYLVLS SVLTAMSRSS DIQRGITRIF HRTAKATEFI AVMEAILLAG KQIQRLGIKQ DSEMRSMQSA TVRSTLLRKL ISVISSPVVV
0601: DNAGKLLSAL NKEAAVRGDL LDILITSSDQ FPELAEARQA VLVIREKLDS SIASFRKKLA IRNLEFLQVS GITHLIELPV DSKVPMNWVK VNSTKKTIRY
0701: HPPEIVAGLD ELALATEHLA IVNRASWDSF LKSFSRYYTD FKAAVQALAA LDCLHSLSTL SRNKNYVRPE FVDDCEPVEI NIQSGRHPVL ETILQDNFVP
0801: NDTILHAEGE YCQIITGPNM GGKSCYIRQV ALISIMAQVG SFVPASFAKL HVLDGVFTRM GASDSIQHGR STFLEELSEA SHIIRTCSSR SLVILDELGR
0901: GTSTHDGVAI AYATLQHLLA EKRCLVLFVT HYPEIAEISN GFPGSVGTYH VSYLTLQKDK GSYDHDDVTY LYKLVRGLCS RSFGFKVAQL AQIPPSCIRR
1001: AISMAAKLEA EVRARERNTR MGEPEGHEEP RGAEESISAL GDLFADLKFA LSEEDPWKAF EFLKHAWKIA GKIRLKPTCS F
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)