AT3G60190.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:cytosol 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : DYNAMIN-like 1E | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
At3g60190 encodes Arabidopsis dynamin-related protein 1E, DRP1E, also known as EDR3, ADL4 and ADL1E, which is 624 amino acid residues long, has a predicted mass of 69.8 kDa and a pI of 7.5. Dynamin-related protein 1E belongs to a plant-specific subclass of dynamin-related proteins (DRP1), consisting of five members in Arabidopsis (A, B, C, D, E). This class is characterized by having an N-terminal GTPase domain, a central ‘dynamin 2‘ domain and a C-terminal GTPase effector domain (GED), a typical structure for plant dynamin-related proteins. However, this class lacks a PH domain and a proline-rich domain, which are found in classical animal dynamin-like proteins. Based on work on animal dynamins, the plant DRP1 proteins should be able to form polymeric structures that wrap around membranes to facilitate membrane tubulation and pinching off of vesicles, processes that are essential to vesicle trafficking and membrane compartmentalization. The edr3 mutation causes a P77L substitution in the G2 motif of the GTPase domain of DRP1E. edr3 mutant Arabidopsis plants display enhanced cell death in response to powdery mildew infection. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
DYNAMIN-like 1E (DL1E); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: response to cadmium ion, vesicle-mediated transport, defense response to fungus; LOCATED IN: mitochondrion, plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1D (TAIR:AT2G44590.3); Has 2915 Blast hits to 2753 proteins in 324 species: Archae - 2; Bacteria - 53; Metazoa - 1058; Fungi - 869; Plants - 577; Viruses - 0; Other Eukaryotes - 356 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:-:22244367..22247651 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 69807.80 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.59 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.33 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 624 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MTTMESLIGL VNRIQRACTV LGDYGGGTGS NAFNSLWEAL PTVAVVGGQS SGKSSVLESI VGRDFLPRGS GIVTRRPLVL QLHKTDDGTE EYAEFLHLPK 101: KQFTDFALVR REIQDETDRI TGKNKQISPV PIHLSIYSPN VVNLTLIDLP GLTKVAVEGQ PETIAEDIES MVRTYVDKPN CIILAISPAN QDIATSDAIK 201: LAKDVDPTGE RTFGVLTKLD LMDKGTNALE VLEGRSYRLQ HPWVGIVNRS QADINKNVDM MLARRKEREY FDTSPDYGHL ASKMGSEYLA KLLSKHLESV 301: IRTRIPSILS LINKSIEELE RELDRMGRPV AVDAGAQLYT ILEMCRAFDK IFKEHLDGGR PGGDRIYGVF DNQLPAALKK LPFDRHLSLQ SVKKIVSEAD 401: GYQPHLIAPE QGYRRLIEGA LGYFRGPAEA SVDAVHYVLK ELVRKSISET EELKRFPSLQ VELAAAANSS LEKFREESKK SVIRLVDMES AYLTAEFFRK 501: LPQEIERPVT NSKNQTASPS SATLDQYGDG HFRRIASNVS AYVNMVSDTL RNTIPKACVY CQVRQAKLAL LNYFYSQISK REGKQLGQLL DEDPALMDRR 601: LECAKRLELY KKARDEIDAV AWVR |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)