AT5G11390.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 0.978 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : WPP domain-interacting protein 1 | ||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells. | ||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
WPP domain-interacting protein 1 (WIT1); BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 2 (TAIR:AT1G68910.1); Has 69833 Blast hits to 39390 proteins in 2372 species: Archae - 1132; Bacteria - 10633; Metazoa - 34082; Fungi - 6202; Plants - 3742; Viruses - 161; Other Eukaryotes - 13881 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:3633971..3636418 | ||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 79052.80 Da | ||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 4.41 | ||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.62 | ||||||||||||||||||||||||||||||||||||||||
| Length | 703 amino acids | ||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: METETEHDRT VSVDDNDSLV PEPSSTKESF FEDLSLTGQV MNPQLSSAGE VLTKVELDFA FVSEKLVNLS LLTMQLGTRE NDFESFVSKK EEDEEEPSSN 101: VDDDDDSAEK ALEFDLLSSI LNSEVKELES LLGFLQNEIQ SARVMISPFQ HDGEAFLDLE GKLNDTEQSL GQLMEQVVEM KKQSSNFQRL SSGLDEQGSW 201: SGGQTSVSQN DGEFGDLSAK INMQTADQQR NVLRMLEKSL AKEMELEKKL SESRNTEREL EMKLYSSEQD VVYMEEVTED AFSRWLEADN AAEVFKGTSK 301: EMSGKLQILQ FNLSGSFKRE DNLKSKLVDS KERLEAKECA LHKLDSSNAR LADFLVAQTE GLKESLQEAE EKLILLNTEN STLSEKVSSL EEQLNEYGIQ 401: TEDADATSGA LITDLERINE ELKDKLAKTE ARAEETESKC KILEESKKEL QDELGNFRDK GFTIHKLASL EKHLRDSDLQ LEHAVAAVEA SKEKQNLLYS 501: TVSDMEDVIE DLKSKVLKAE NRADITEEKL IMVSESNAEV NEELKFFKGR LKEGEKYLQQ AEERKLRTAK DIGVHNKIMK KLVMQLAAER ERLHKQITNL 601: SRENCVLMVK LKKVGKTGYM ESGNGSEVSP KSDQNASSCH QGSRLQATFI SLTNPEEEET GSKSDIGSVR RLDVGALRFK HILVAILVIL ISSIAYVISQ 701: QNM |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)