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AT5G04510.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : 3'-phosphoinositide-dependent protein kinase 1
Curator
Summary (TAIR10)
Encodes 3-phosphoinositide-dependent protein kinase that contains pleckstrin homology domain and binds 3-phosphoinositides. It activates the protein kinase AGC2-1 in a phosphatidic acid dependent manner. Phosphorylates S6K1. Interacts with PID, and transphosphorylation by PDK1 increases PID autophosphorylation.
Computational
Description (TAIR10)
3'-phosphoinositide-dependent protein kinase 1 (PDK1); FUNCTIONS IN: 3-phosphoinositide-dependent protein kinase activity, protein binding, phosphoinositide binding, protein kinase activity, kinase activity; INVOLVED IN: positive regulation of protein kinase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Serine/threonine-protein kinase-1, 3-phosphoinositide dependent (InterPro:IPR015746), Protein kinase, catalytic domain (InterPro:IPR000719), Pleckstrin homology-type (InterPro:IPR011993); BEST Arabidopsis thaliana protein match is: 3-phosphoinositide-dependent protein kinase (TAIR:AT3G10540.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G04510-MONOMERBioCyc:ARA:GQT-1887-MONOMERBioGrid:15609DIP:DIP-39596N
DNASU:830330EC:2.7.11.1eggNOG:ENOG410XRT8eggNOG:KOG0592
EMBL:AF132742EMBL:AF360326EMBL:AL162875EMBL:AY056336
EMBL:CP002688EnsemblPlants:AT5G04510EnsemblPlants:AT5G04510.1entrez:830330
ExpressionAtlas:Q9XF67Gene3D:2.30.29.30GeneID:830330Genevisible:Q9XF67
GO:GO:0004672GO:GO:0004674GO:GO:0005524GO:GO:0005622
GO:GO:0005737GO:GO:0016020GO:GO:0016301GO:GO:0018105
GO:GO:0035091GO:GO:0035556GO:GO:0045860GO:GO:0046777
GO:GO:0070300hmmpanther:PTHR24356hmmpanther:PTHR24356:SF163HOGENOM:HOG000233026
InParanoid:Q9XF67IntAct:Q9XF67InterPro:IPR000719InterPro:IPR008271
InterPro:IPR011009InterPro:IPR011993iPTMnet:Q9XF67KEGG:ath:AT5G04510
KO:K06276ncoils:CoilOMA:QENFTSHPaxDb:Q9XF67
Pfam:PF00069Pfam:PF14593Pfam:Q9XF67Pfscan:PS50011
PhylomeDB:Q9XF67PIR:T48447PRIDE:Q9XF67PRO:PR:Q9XF67
PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:Q9XF67Proteomes:UP000006548
Reactome:R-ATH-1257604Reactome:R-ATH-165158Reactome:R-ATH-202424Reactome:R-ATH-2730905
Reactome:R-ATH-389357Reactome:R-ATH-5218920RefSeq:NP_568138.1scanprosite:PS00108
SMART:SM00220SMR:Q9XF67STRING:3702.AT5G04510.1SUPFAM:SSF50729
SUPFAM:SSF56112TAIR:AT5G04510tair10-symbols:ATPDK1tair10-symbols:PDK1
UniGene:At.4924UniProt:Q9XF67
Coordinates (TAIR10) chr5:+:1287235..1289681
Molecular Weight (calculated) 54714.00 Da
IEP (calculated) 8.29
GRAVY (calculated) -0.40
Length 491 amino acids
Sequence (TAIR10)
(BLAST)
001: MLAMEKEFDS KLVLQGNSSN GANVSRSKSF SFKAPQENFT SHDFEFGKIY GVGSYSKVVR AKKKETGTVY ALKIMDKKFI TKENKTAYVK LERIVLDQLE
101: HPGIIKLYFT FQDTSSLYMA LESCEGGELF DQITRKGRLS EDEARFYTAE VVDALEYIHS MGLIHRDIKP ENLLLTSDGH IKIADFGSVK PMQDSQITVL
201: PNAASDDKAC TFVGTAAYVP PEVLNSSPAT FGNDLWALGC TLYQMLSGTS PFKDASEWLI FQRIIARDIK FPNHFSEAAR DLIDRLLDTE PSRRPGAGSE
301: GYVALKRHPF FNGVDWKNLR SQTPPKLAPD PASQTASPER DDTHGSPWNL THIGDSLATQ NEGHSAPPTS SESSGSITRL ASIDSFDSRW QQFLEPGESV
401: LMISAVKKLQ KITSKKVQLI LTNKPKLIYV DPSKLVVKGN IIWSDNSNDL NVVVTSPSHF KICTPKKVLS FEDAKQRASV WKKAIETLQN R
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)