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AT3G54610.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:30961429 (2019): nucleus
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:14617066 (2003): nucleus
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : histone acetyltransferase of the GNAT family 1
Curator
Summary (TAIR10)
Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an H3 peptide that had been previously acetylated on K9 both serve as excellent substrates for HAG1-catalyzed acetylation. However, prior acetylation of H3 lysine 14 blocks radioactive acetylation of the peptide by HAG1. HAG1 is specific for histone H3 lysine 14.
Computational
Description (TAIR10)
histone acetyltransferase of the GNAT family 1 (HAG1); FUNCTIONS IN: histone acetyltransferase activity, DNA binding, H3 histone acetyltransferase activity; INVOLVED IN: flower development, histone acetylation, response to light stimulus, positive regulation of transcription, root morphogenesis; LOCATED IN: histone acetyltransferase complex, nucleus; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Bromodomain, conserved site (InterPro:IPR018359), Acyl-CoA N-acyltransferase (InterPro:IPR016181), Bromodomain (InterPro:IPR001487); BEST Arabidopsis thaliana protein match is: nuclear protein X1 (TAIR:AT5G63320.1); Has 13698 Blast hits to 5805 proteins in 367 species: Archae - 4; Bacteria - 1437; Metazoa - 4852; Fungi - 1484; Plants - 516; Viruses - 1; Other Eukaryotes - 5404 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G54610-MONOMERBioGrid:9942BRENDA:2.3.1.48EC:2.3.1.48
eggNOG:COG5076eggNOG:KOG1472EMBL:AF031958EMBL:AF037442
EMBL:AF338768EMBL:AF338771EMBL:AL138656EMBL:BT002057
EMBL:BT008909EMBL:CP002686EnsemblPlants:AT3G54610EnsemblPlants:AT3G54610.1
entrez:824626Gene3D:1.20.920.10Gene3D:3.40.630.30GeneID:824626
Genevisible:Q9AR19GO:GO:0000123GO:GO:0003677GO:GO:0004402
GO:GO:0005634GO:GO:0006351GO:GO:0009416GO:GO:0009908
GO:GO:0010015GO:GO:0010321GO:GO:0010484GO:GO:0016407
GO:GO:0016573GO:GO:0043966GO:GO:0045893Gramene:AT3G54610.1
hmmpanther:PTHR22880HOGENOM:HOG000192257InParanoid:Q9AR19IntAct:Q9AR19
InterPro:IPR000182InterPro:IPR001487InterPro:IPR016181InterPro:IPR018359
iPTMnet:Q9AR19KEGG:ath:AT3G54610KO:K06062OMA:RWHGYIK
PaxDb:Q9AR19Pfam:PF00439Pfam:PF00583Pfam:PF13508
Pfam:Q9AR19Pfscan:PS50014Pfscan:PS51186PhylomeDB:Q9AR19
PIR:T47620PRIDE:Q9AR19PRINTS:PR00503PRO:PR:Q9AR19
PROSITE:PS00633PROSITE:PS50014PROSITE:PS51186ProteinModelPortal:Q9AR19
Proteomes:UP000006548RefSeq:NP_567002.1scanprosite:PS00633SMART:SM00297
SMR:Q9AR19STRING:3702.AT3G54610.1SUPFAM:SSF47370SUPFAM:SSF55729
TAIR:AT3G54610tair10-symbols:BGTtair10-symbols:GCN5tair10-symbols:HAC3
tair10-symbols:HAG01tair10-symbols:HAG1tair10-symbols:HAT1UniGene:At.10490
UniProt:Q9AR19
Coordinates (TAIR10) chr3:+:20213593..20217375
Molecular Weight (calculated) 63127.00 Da
IEP (calculated) 6.42
GRAVY (calculated) -0.58
Length 568 amino acids
Sequence (TAIR10)
(BLAST)
001: MDSHSSHLNA ANRSRSSQTP SPSHSASASV TSSLHKRKLA ATTAANAAAS EDHAPPSSSF PPSSFSADTR DGALTSNDEL ESISARGADT DSDPDESEDI
101: VVDDDEDEFA PEQDQDSSIR TFTAARLDSS SGVNGSSRNT KLKTESSTVK LESSDGGKDG GSSVVGTGVS GTVGGSSISG LVPKDESVKV LAENFQTSGA
201: YIAREEALKR EEQAGRLKFV CYSNDSIDEH MMCLIGLKNI FARQLPNMPK EYIVRLLMDR KHKSVMVLRG NLVVGGITYR PYHSQKFGEI AFCAITADEQ
301: VKGYGTRLMN HLKQHARDVD GLTHFLTYAD NNAVGYFVKQ GFTKEIYLEK DVWHGFIKDY DGGLLMECKI DPKLPYTDLS SMIRQQRKAI DERIRELSNC
401: QNVYPKIEFL KNEAGIPRKI IKVEEIRGLR EAGWTPDQWG HTRFKLFNGS ADMVTNQKQL NALMRALLKT MQDHADAWPF KEPVDSRDVP DYYDIIKDPI
501: DLKVIAKRVE SEQYYVTLDM FVADARRMFN NCRTYNSPDT IYYKCATRLE THFHSKVQAG LQSGAKSQ
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)