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AT2G39800.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
peroxisome 0.922
cytosol 0.078
ASURE: cytosol,plastid
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31615849 (2019): plastid plastid thylakoid
  • PMID:31520498 (2020): mitochondrion
  • PMID:30962257 (2019): plastid
  • PMID:30447334 (2019): plasma membrane
  • PMID:27122571 (2016): mitochondrion
  • PMID:22550958 (2012): plastid
  • PMID:21988472 (2012): plant-type vacuole plant-type vacuole membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : delta1-pyrroline-5-carboxylate synthase 1
Curator
Summary (TAIR10)
encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. P5CS1 appears to be involved in salt stress responses related to proline accumulation, including protection from reactive oxidative species. P5CS1 appears to be present in different cells and/or different subcellular locations from P5CS2 in a tissue-dependent manner.
Computational
Description (TAIR10)
delta1-pyrroline-5-carboxylate synthase 1 (P5CS1); FUNCTIONS IN: delta1-pyrroline-5-carboxylate synthetase activity; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast, membrane, cytoplasm; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: C globular stage, D bilateral stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Glutamate 5-kinase (InterPro:IPR001057), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Glutamate 5-kinase, conserved site (InterPro:IPR019797), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Gamma-glutamyl phosphate reductase GPR, conserved site (InterPro:IPR020593), Aldehyde dehydrogenase, C-terminal (InterPro:IPR016163), Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Delta l-pyrroline-5-carboxylate synthetase (InterPro:IPR005766), Gamma-glutamyl phosphate reductase GPR (InterPro:IPR000965), Aldehyde dehydrogenase (InterPro:IPR015590), Glutamate 5-kinase, ProB-related (InterPro:IPR005715); BEST Arabidopsis thaliana protein match is: delta 1-pyrroline-5-carboxylate synthase 2 (TAIR:AT3G55610.1); Has 14932 Blast hits to 14924 proteins in 2380 species: Archae - 163; Bacteria - 9254; Metazoa - 175; Fungi - 266; Plants - 182; Viruses - 0; Other Eukaryotes - 4892 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G39800-MONOMERBioCyc:ARA:GQT-2788-MONOMERBioCyc:ARA:GQT-2789-MONOMERBioCyc:ARA:GQT-2790-MONOMER
BioCyc:MetaCyc:AT2G39800-MONOMERBioGrid:3904EC:1.2.1.41EC:2.7.2.11
eggNOG:COG0014eggNOG:COG0263eggNOG:KOG1154eggNOG:KOG4165
EMBL:AC003000EMBL:AF424633EMBL:AY113046EMBL:AY150430
EMBL:CP002685EMBL:D32138EMBL:X86777EMBL:X87330
EMBL:X89414EnsemblPlants:AT2G39800EnsemblPlants:AT2G39800.1EnsemblPlants:AT2G39800.4
entrez:818566ExpressionAtlas:P54887Gene3D:3.40.1160.10Gene3D:3.40.309.10
Gene3D:3.40.605.10GeneID:818566Genevisible:P54887GO:GO:0004349
GO:GO:0004350GO:GO:0005524GO:GO:0005737GO:GO:0006561
GO:GO:0006979GO:GO:0009414GO:GO:0009507GO:GO:0009555
GO:GO:0009651GO:GO:0016020GO:GO:0017084GO:GO:0042538
GO:GO:0048364GO:GO:0055129gramene_pathway:1.2.1.41gramene_pathway:2.7.2.11
gramene_pathway:CITRULBIO-PWYgramene_pathway:PWY-3341gramene_plant_reactome:1119495gramene_plant_reactome:6874531
gramene_plant_reactome:6876564HAMAP:MF_00412HAMAP:MF_00456hmmpanther:PTHR11063
hmmpanther:PTHR11063:SF8HOGENOM:HOG000246357InParanoid:P54887IntAct:P54887
InterPro:IPR000965InterPro:IPR001048InterPro:IPR001057InterPro:IPR005715
InterPro:IPR005766InterPro:IPR015590InterPro:IPR016161InterPro:IPR016162
InterPro:IPR016163InterPro:IPR019797InterPro:IPR020593iPTMnet:P54887
KEGG:00330+1.2.1.41KEGG:00330+1.2.1.41+2.7.2.11KEGG:00330+2.7.2.11KEGG:00332+1.2.1.41
KEGG:00332+1.2.1.41+2.7.2.11KEGG:00332+2.7.2.11KEGG:ath:AT2G39800KO:K12657
OMA:KVNAALWPaxDb:P54887Pfam:P54887Pfam:PF00171
Pfam:PF00696PhylomeDB:P54887PIR:S66637PIR:T50685
PIRSF:PIRSF036429PRIDE:P54887PRINTS:PR00474PRO:PR:P54887
PROSITE:PS00902PROSITE:PS01223ProteinModelPortal:P54887Proteomes:UP000006548
Reactome:R-ATH-70614RefSeq:NP_001189714.1RefSeq:NP_181510.1scanprosite:PS00902
scanprosite:PS01223SMR:P54887STRING:3702.AT2G39800.1SUPFAM:SSF53633
SUPFAM:SSF53720TAIR:AT2G39800tair10-symbols:ATP5CStair10-symbols:P5CS1
TIGRfam:TIGR00407TIGRfam:TIGR01027TIGRfam:TIGR01092TIGRFAMs:TIGR00407
TIGRFAMs:TIGR01027TIGRFAMs:TIGR01092UniGene:At.20482UniPathway:UPA00098
UniProt:P54887
Coordinates (TAIR10) chr2:-:16598516..16602939
Molecular Weight (calculated) 77706.40 Da
IEP (calculated) 6.22
GRAVY (calculated) -0.07
Length 717 amino acids
Sequence (TAIR10)
(BLAST)
001: MEELDRSRAF ARDVKRIVVK VGTAVVTGKG GRLALGRLGA LCEQLAELNS DGFEVILVSS GAVGLGRQRL RYRQLVNSSF ADLQKPQTEL DGKACAGVGQ
101: SSLMAYYETM FDQLDVTAAQ LLVNDSSFRD KDFRKQLNET VKSMLDLRVI PIFNENDAIS TRRAPYQDSS GIFWDNDSLA ALLALELKAD LLILLSDVEG
201: LYTGPPSDPN SKLIHTFVKE KHQDEITFGD KSRLGRGGMT AKVKAAVNAA YAGIPVIITS GYSAENIDKV LRGLRVGTLF HQDARLWAPI TDSNARDMAV
301: AARESSRKLQ ALSSEDRKKI LLDIADALEA NVTTIKAENE LDVASAQEAG LEESMVARLV MTPGKISSLA ASVRKLADME DPIGRVLKKT EVADGLVLEK
401: TSSPLGVLLI VFESRPDALV QIASLAIRSG NGLLLKGGKE ARRSNAILHK VITDAIPETV GGKLIGLVTS REEIPDLLKL DDVIDLVIPR GSNKLVTQIK
501: NTTKIPVLGH ADGICHVYVD KACDTDMAKR IVSDAKLDYP AACNAMETLL VHKDLEQNAV LNELIFALQS NGVTLYGGPR ASKILNIPEA RSFNHEYCAK
601: ACTVEVVEDV YGAIDHIHRH GSAHTDCIVT EDHEVAELFL RQVDSAAVFH NASTRFSDGF RFGLGAEVGV STGRIHARGP VGVEGLLTTR WIMRGKGQVV
701: DGDNGIVYTH QDIPIQA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)