AT1G04400.1
|
Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:cytosol 0.500 nucleus 0.500 ASURE: cytosol,nucleus What is SUBAcon? |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Localisations and PPI |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
SUBAcon links
AGI-AGI relationships |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description (TAIR10) | protein_coding : cryptochrome 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Blue light receptor mediating blue-light regulated cotyledon expansion and flowering time. Positive regulator of the flowering-time gene CONSTANS. This gene possesses a light-induced CNT2 N-terminal homodimerisation domain.Involved in blue-light induced stomatal opening. Involved in triggering chromatin decondensation. An 80-residue motif (NC80) is sufficient to confer CRY2's physiological function. It is proposed that the PHR domain and the C-terminal tail of the unphosphorylated CRY2 form a "closed" conformation to suppress the NC80 motif in the absence of light. In response to blue light, the C-terminal tail of CRY2 is phosphorylated and electrostatically repelled from the surface of the PHR domain to form an "open" conformation, resulting in derepression of the NC80 motif and signal transduction to trigger photomorphogenic responses. Cry2 phosphorylation and degradation both occur in the nucleus. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
cryptochrome 2 (CRY2); FUNCTIONS IN: protein homodimerization activity, blue light photoreceptor activity; INVOLVED IN: in 9 processes; LOCATED IN: nucleus, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Cryptochrome/DNA photolyase, class 1 conserved site, C-terminal (InterPro:IPR018394), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), Cryptochrome, plant (InterPro:IPR014134), Cryptochrome/DNA photolyase, class 1 (InterPro:IPR002081); BEST Arabidopsis thaliana protein match is: cryptochrome 1 (TAIR:AT4G08920.1); Has 10129 Blast hits to 10113 proteins in 1516 species: Archae - 99; Bacteria - 3201; Metazoa - 386; Fungi - 148; Plants - 723; Viruses - 2; Other Eukaryotes - 5570 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Coordinates (TAIR10) | chr1:-:1185719..1187901 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 69460.60 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 5.83 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.34 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 612 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MKMDKKTIVW FRRDLRIEDN PALAAAAHEG SVFPVFIWCP EEEGQFYPGR ASRWWMKQSL AHLSQSLKAL GSDLTLIKTH NTISAILDCI RVTGATKVVF 101: NHLYDPVSLV RDHTVKEKLV ERGISVQSYN GDLLYEPWEI YCEKGKPFTS FNSYWKKCLD MSIESVMLPP PWRLMPITAA AEAIWACSIE ELGLENEAEK 201: PSNALLTRAW SPGWSNADKL LNEFIEKQLI DYAKNSKKVV GNSTSLLSPY LHFGEISVRH VFQCARMKQI IWARDKNSEG EESADLFLRG IGLREYSRYI 301: CFNFPFTHEQ SLLSHLRFFP WDADVDKFKA WRQGRTGYPL VDAGMRELWA TGWMHNRIRV IVSSFAVKFL LLPWKWGMKY FWDTLLDADL ECDILGWQYI 401: SGSIPDGHEL DRLDNPALQG AKYDPEGEYI RQWLPELARL PTEWIHHPWD APLTVLKASG VELGTNYAKP IVDIDTAREL LAKAISRTRE AQIMIGAAPD 501: EIVADSFEAL GANTIKEPGL CPSVSSNDQQ VPSAVRYNGS KRVKPEEEEE RDMKKSRGFD ERELFSTAES SSSSSVFFVS QSCSLASEGK NLEGIQDSSD 601: QITTSLGKNG CK |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| See Also |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)