AT4G03560.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:vacuole 1.000 ASURE: vacuole What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : two-pore channel 1 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes a depolarization-activated Ca(2+) channel. Anti-sense experiments with this gene as well as Sucrose-H(+) symporters and complementation of yeast sucrose uptake mutant cch1 suggest that this protein mediates a voltage-activated Ca(2+ )influx. Mutants lack detectable SV channel activity suggesting TPC1 is essential component of the SV channel. Patch clamp analysis of loss of function mutation indicates TPC1 does not affect Ca2+ signaling in response to abiotic and biotic stress. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
two-pore channel 1 (TPC1); FUNCTIONS IN: voltage-gated calcium channel activity, calcium channel activity; INVOLVED IN: regulation of jasmonic acid biosynthetic process, calcium ion transport, calcium-mediated signaling, seed germination, regulation of stomatal movement; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-HAND 2 (InterPro:IPR018249), Ion transport (InterPro:IPR005821), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr4:+:1580253..1585691 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 84877.90 Da | ||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 4.62 | ||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | 0.24 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 733 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MEDPLIGRDS LGGGGTDRVR RSEAITHGTP FQKAAALVDL AEDGIGLPVE ILDQSSFGES ARYYFIFTRL DLIWSLNYFA LLFLNFFEQP LWCEKNPKPS 101: CKDRDYYYLG ELPYLTNAES IIYEVITLAI LLVHTFFPIS YEGSRIFWTS RLNLVKVACV VILFVDVLVD FLYLSPLAFD FLPFRIAPYV RVIIFILSIR 201: ELRDTLVLLS GMLGTYLNIL ALWMLFLLFA SWIAFVMFED TQQGLTVFTS YGATLYQMFI LFTTSNNPDV WIPAYKSSRW SSVFFVLYVL IGVYFVTNLI 301: LAVVYDSFKE QLAKQVSGMD QMKRRMLEKA FGLIDSDKNG EIDKNQCIKL FEQLTNYRTL PKISKEEFGL IFDELDDTRD FKINKDEFAD LCQAIALRFQ 401: KEEVPSLFEH FPQIYHSALS QQLRAFVRSP NFGYAISFIL IINFIAVVVE TTLDIEESSA QKPWQVAEFV FGWIYVLEMA LKIYTYGFEN YWREGANRFD 501: FLVTWVIVIG ETATFITPDE NTFFSNGEWI RYLLLARMLR LIRLLMNVQR YRAFIATFIT LIPSLMPYLG TIFCVLCIYC SIGVQVFGGL VNAGNKKLFE 601: TELAEDDYLL FNFNDYPNGM VTLFNLLVMG NWQVWMESYK DLTGTWWSIT YFVSFYVITI LLLLNLVVAF VLEAFFTELD LEEEEKCQGQ DSQEKRNRRR 701: SAGSKSRSQR VDTLLHHMLG DELSKPECST SDT |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)