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AT1G63440.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
plasma membrane 0.997
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : heavy metal atpase 5
Curator
Summary (TAIR10)
The Arabidopsis P-type ATPase HMA5 is involved in Cu detoxification. hma5 mutant plants exhibit Cu hypersensitivity, which is especially dramatic in roots where HMA5 is mostly expressed.
Computational
Description (TAIR10)
heavy metal atpase 5 (HMA5); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: detoxification of copper ion, response to copper ion; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Heavy-metal-associated, conserved site (InterPro:IPR017969), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1) (TAIR:AT5G44790.1); Has 47061 Blast hits to 34034 proteins in 3459 species: Archae - 1020; Bacteria - 31793; Metazoa - 4958; Fungi - 2589; Plants - 1873; Viruses - 3; Other Eukaryotes - 4825 (source: NCBI BLink).
Protein Annotations
eggNOG:COG2217eggNOG:KOG0207EMBL:EU877767EMBL:EU877768
EMBL:EU877770EMBL:EU877774EMBL:EU877776EMBL:EU877778
EMBL:EU877779EMBL:EU877787EMBL:EU877789EMBL:EU877790
EMBL:EU877792EMBL:EU877795EMBL:EU877796EMBL:EU877799
EMBL:EU877800EMBL:EU877801EMBL:EU877803EnsemblPlants:AT1G63440
EnsemblPlants:AT1G63440.1entrez:842650ExpressionAtlas:B5AXI8Gene3D:2.70.150.10
Gene3D:3.40.1110.10Gene3D:3.40.50.1000GeneID:842650GO:GO:0000166
GO:GO:0005507GO:GO:0016021GO:GO:0019829GO:GO:0030001
Gramene:AT1G63440.1hmmpanther:PTHR24093hmmpanther:PTHR24093:SF315InterPro:IPR001757
InterPro:IPR006121InterPro:IPR006122InterPro:IPR008250InterPro:IPR017969
InterPro:IPR018303InterPro:IPR023214InterPro:IPR023299InterPro:IPR027256
KEGG:ath:AT1G63440KO:K17686OMA:SEENHIWPfam:PF00122
Pfam:PF00403Pfam:PF00702Pfam:Q9SH30Pfscan:PS50846
PhylomeDB:B5AXI8PROSITE:PS00154PROSITE:PS01047PROSITE:PS50846
RefSeq:NP_176533.1scanprosite:PS00154scanprosite:PS01047SMR:B5AXI8
STRING:3702.AT1G63440.1SUPFAM:0049471SUPFAM:0049473SUPFAM:SSF55008
SUPFAM:SSF56784TAIR:AT1G63440tair10-symbols:HMA5TIGRfam:TIGR00003
TIGRfam:TIGR01494TIGRfam:TIGR01525TIGRFAMs:TIGR00003TIGRFAMs:TIGR01494
TIGRFAMs:TIGR01525TMHMM:TMhelixUniGene:At.36129UniProt:B5AXI8
UniProt:Q9SH30
Coordinates (TAIR10) chr1:+:23527655..23531109
Molecular Weight (calculated) 108343.00 Da
IEP (calculated) 6.37
GRAVY (calculated) 0.13
Length 995 amino acids
Sequence (TAIR10)
(BLAST)
001: MATKLLSLTC IRKERFSERY PLVRKHLTRS RDGGGGSSSE TAAFEIDDPI SRAVFQVLGM TCSACAGSVE KAIKRLPGIH DAVIDALNNR AQILFYPNSV
101: DVETIRETIE DAGFEASLIE NEANERSRQV CRIRINGMTC TSCSSTIERV LQSVNGVQRA HVALAIEEAE IHYDPRLSSY DRLLEEIENA GFEAVLISTG
201: EDVSKIDLKI DGELTDESMK VIERSLEALP GVQSVEISHG TDKISVLYKP DVTGPRNFIQ VIESTVFGHS GHIKATIFSE GGVGRESQKQ GEIKQYYKSF
301: LWSLVFTVPV FLTAMVFMYI PGIKDLLMFK VINMLTVGEI IRCVLATPVQ FVIGWRFYTG SYKALRRGSA NMDVLIALGT NAAYFYSLYT VLRAATSPDF
401: KGVDFFETSA MLISFIILGK YLEVMAKGKT SQAIAKLMNL APDTAILLSL DKEGNVTGEE EIDGRLIQKN DVIKIVPGAK VASDGYVIWG QSHVNESMIT
501: GEARPVAKRK GDTVIGGTLN ENGVLHVKVT RVGSESALAQ IVRLVESAQL AKAPVQKLAD RISKFFVPLV IFLSFSTWLA WFLAGKLHWY PESWIPSSMD
601: SFELALQFGI SVMVIACPCA LGLATPTAVM VGTGVGASQG VLIKGGQALE RAHKVNCIVF DKTGTLTMGK PVVVKTKLLK NMVLREFYEL VAATEVNSEH
701: PLAKAIVEYA KKFRDDEENP AWPEACDFVS ITGKGVKATV KGREIMVGNK NLMNDHKVII PDDAEELLAD SEDMAQTGIL VSINSELIGV LSVSDPLKPS
801: AREAISILKS MNIKSIMVTG DNWGTANSIA REVGIDSVIA EAKPEQKAEK VKELQAAGHV VAMVGDGIND SPALVAADVG MAIGAGTDIA IEAADIVLMK
901: SNLEDVITAI DLSRKTFSRI RLNYVWALGY NLMGIPIAAG VLFPGTRFRL PPWIAGAAMA ASSVSVVCCS LLLKNYKRPK KLDHLEIREI QVERV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)