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AT2G17370.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
endoplasmic reticulum 0.643
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : 3-hydroxy-3-methylglutaryl-CoA reductase 2
Curator
Summary (TAIR10)
Encodes a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that is involved in the synthesis of sterol and triterpenoid compounds.
Computational
Description (TAIR10)
3-hydroxy-3-methylglutaryl-CoA reductase 2 (HMG2); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: hydroxy methylglutaryl CoA reductase 1 (TAIR:AT1G76490.1); Has 2106 Blast hits to 2105 proteins in 886 species: Archae - 203; Bacteria - 937; Metazoa - 224; Fungi - 225; Plants - 261; Viruses - 1; Other Eukaryotes - 255 (source: NCBI BLink).
Protein Annotations
BioGrid:1601EC:1.1.1.34eggNOG:COG1257eggNOG:KOG2480
EMBL:AY057680EMBL:AY143930EMBL:CP002685EMBL:L19262
EnsemblPlants:AT2G17370EnsemblPlants:AT2G17370.1entrez:816244Gene3D:1.10.3270.10
Gene3D:3.30.70.420Gene3D:3.90.770.10GeneID:816244Genevisible:P43256
GO:GO:0004420GO:GO:0005778GO:GO:0005789GO:GO:0008299
GO:GO:0015936GO:GO:0016021GO:GO:0016104GO:GO:0016126
GO:GO:0042282GO:GO:0043231GO:GO:0050661Gramene:AT2G17370.1
gramene_plant_reactome:1119615gramene_plant_reactome:6875859hmmpanther:PTHR10572hmmpanther:PTHR10572:SF7
HOGENOM:HOG000050844InParanoid:P43256InterPro:IPR002202InterPro:IPR004554
InterPro:IPR009023InterPro:IPR009029InterPro:IPR023074InterPro:IPR023076
InterPro:IPR023282iPTMnet:P43256KEGG:00900+1.1.1.34KEGG:ath:AT2G17370
KO:K00021OMA:KHVVCEAPANTHER:PTHR10572PaxDb:P43256
Pfam:P43256Pfam:PF00368Pfscan:PS50065PhylomeDB:P43256
PIR:D84551PRIDE:P43256PRINTS:PR00071PRO:PR:P43256
PROSITE:PS00066PROSITE:PS00318PROSITE:PS01192PROSITE:PS50065
ProteinModelPortal:P43256Proteomes:UP000006548Reactome:R-ATH-191273RefSeq:NP_179329.1
scanprosite:PS00066scanprosite:PS00318scanprosite:PS01192SMR:P43256
STRING:3702.AT2G17370.1SUPFAM:SSF55035SUPFAM:SSF56542TAIR:AT2G17370
tair10-symbols:HMG2tair10-symbols:HMGR2TIGRfam:TIGR00533TIGRFAMs:TIGR00533
TMHMM:TMhelixUniGene:At.432UniPathway:UPA00058UniProt:P43256
Coordinates (TAIR10) chr2:+:7550007..7551981
Molecular Weight (calculated) 60718.40 Da
IEP (calculated) 6.40
GRAVY (calculated) 0.09
Length 562 amino acids
Sequence (TAIR10)
(BLAST)
001: MEDLRRRFPT KKNGEEISNV AVDPPLRKAS DALPLPLYLT NTFFLSLFFA TVYFLLSRWR EKIRNSTPLH VVDLSEICAL IGFVASFIYL LGFCGIDLIF
101: RSSSDDDVWV NDGMIPCNQS LDCREVLPIK PNSVDPPRES ELDSVEDEEI VKLVIDGTIP SYSLETKLGD CKRAAAIRRE AVQRITGKSL TGLPLEGFDY
201: NSILGQCCEM PVGYVQIPVG IAGPLLLDGV EYSVPMATTE GCLVASTNRG FKAIHLSGGA FSVLVKDAMT RAPVVRFPSA RRAALVMFYL QDPSNFERLS
301: LIFNKSSRFA RLQSITCTIA GRNLYPRFAC STGDAMGMNM VSKGVQNVLD FVKSEFPDMD VIGISGNYCS DKKASAVNWI EGRGKHVVCE AFIKAEIVEK
401: VLKTSVEALV ELNTLKNLVG SAMAGSLGGF NAHSSNIVSA VFIATGQDPA QNVESSHCMT MILPDGDDLH ISVSMPCIEV GTVGGGTQLA SQAACLNLLG
501: VKGSNNEKPG SNAQQLARIV AGSVLAGELS LMSAIAAGQL VKSHMKYNRS SRDIGPSSQV NR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)