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AT4G00570.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
mitochondrion 1.000
ASURE: mitochondrion
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : NAD-dependent malic enzyme 2
Curator
Summary (TAIR10)
Encodes an NAD-dependent malic enzyme (NAD-ME) that does not act on oxaloacetate, indicating that it belongs to EC 1.1.1.39. It is a member of the beta family of NAD-MEs in plants. It appears to function as a homodimer or as a heterodimer with the alpha-type NAD-ME2 (At2g13560). NAD-ME2 transcript and protein levels are higher during the night than during the day.
Computational
Description (TAIR10)
NAD-dependent malic enzyme 2 (NAD-ME2); FUNCTIONS IN: in 7 functions; INVOLVED IN: malate metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD-dependent malic enzyme 1 (TAIR:AT2G13560.1); Has 9343 Blast hits to 9326 proteins in 2439 species: Archae - 143; Bacteria - 6323; Metazoa - 607; Fungi - 223; Plants - 463; Viruses - 0; Other Eukaryotes - 1584 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G00570-MONOMERBioGrid:13511BRENDA:1.1.1.39EC:1.1.1.39
eggNOG:COG0281eggNOG:KOG1257EMBL:AF058919EMBL:AL161472
EMBL:AY128396EMBL:BT000075EMBL:BT002046EMBL:BT008375
EMBL:CP002687EnsemblPlants:AT4G00570EnsemblPlants:AT4G00570.1entrez:828222
Gene3D:3.40.50.10380Gene3D:3.40.50.720GeneID:828222Genevisible:Q8L7K9
GO:GO:0004471GO:GO:0005524GO:GO:0005739GO:GO:0006108
GO:GO:0008270GO:GO:0009507GO:GO:0042803GO:GO:0050897
GO:GO:0051287Gramene:AT4G00570.1hmmpanther:PTHR23406hmmpanther:PTHR23406:SF32
HOGENOM:HOG000042486InParanoid:Q8L7K9IntAct:Q8L7K9InterPro:IPR001891
InterPro:IPR012301InterPro:IPR012302InterPro:IPR015884InterPro:IPR016040
KEGG:ath:AT4G00570KO:K00028OMA:DLAEGCCPaxDb:Q8L7K9
Pfam:PF00390Pfam:PF03949Pfam:Q8L7K9PhylomeDB:Q8L7K9
PIR:T01221PIRSF:PIRSF000106PRIDE:Q8L7K9PRINTS:PR00072
PRO:PR:Q8L7K9PROSITE:PS00331ProteinModelPortal:Q8L7K9Proteomes:UP000006548
RefSeq:NP_191966.2scanprosite:PS00331SMART:SM00919SMART:SM01274
SMR:Q8L7K9STRING:3702.AT4G00570.1SUPFAM:SSF51735SUPFAM:SSF53223
TAIR:AT4G00570tair10-symbols:NAD-ME2UniGene:At.34536UniProt:Q8L7K9
Coordinates (TAIR10) chr4:-:242817..246522
Molecular Weight (calculated) 66644.60 Da
IEP (calculated) 7.07
GRAVY (calculated) -0.09
Length 607 amino acids
Sequence (TAIR10)
(BLAST)
001: MMWKNIAGLS KAAAAARTHG SRRCFSTAIP GPCIVHKRGA DILHDPWFNK DTGFPLTERD RLGIRGLLPP RVMTCVQQCD RFIESFRSLE NNTKGEPENV
101: VALAKWRMLN RLHDRNETLY YRVLIDNIKD FAPIIYTPTV GLVCQNYSGL YRRPRGMYFS AKDKGEMMSM IYNWPAPQVD MIVITDGSRI LGLGDLGVQG
201: IGIPIGKLDM YVAAAGINPQ RVLPIMLDVG TNNEKLLQND LYLGVRQPRL EGEEYLEIID EFMEAAFTRW PKAVVQFEDF QAKWAFGTLE RYRKKFCMFN
301: DDVQGTAGVA LAGLLGTVRA QGRPISDFVN QKIVVVGAGS AGLGVTKMAV QAVARMAGIS ESEATKNFYL IDKDGLVTTE RTKLDPGAVL FAKNPAEIRE
401: GASIVEVVKK VRPHVLLGLS GVGGIFNEEV LKAMRESDSC KPAIFAMSNP TLNAECTAAD AFKHAGGNIV FASGSPFENV ELENGKVGHV NQANNMYLFP
501: GIGLGTLLSG ARIVTDGMLQ AASECLASYM TDEEVQKGIL YPSINNIRHI TAEVGAAVLR AAVTDDIAEG HGDVGPKDLS HMSKEDTVNY ITRNMWFPVY
601: SPLVHEK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)