AT5G19400.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : Telomerase activating protein Est1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
SMG7; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2); Has 648 Blast hits to 623 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 367; Fungi - 169; Plants - 90; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:6540603..6544262 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 117012.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.25 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.41 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 1059 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MMTLQMDKTT ASSSWERAKS IYDEIAELAN KRQKAGNPPD PNLLQLLREK YEAIILESHT FSEQHNIEIP LWQLHYKRIE YFRLHINRVL ASSTSTAAQN 0101: VKGPSKAEQI AQLKLQFRTF LSEATGFYHD MILKIRSKYG LPLGSFSEDQ QSQNLSDKDG KELAEVQKAL KSCHRCLIYL GDLARYKGMY AEGDSRSRQY 0201: ASASSYYLQA ASLWPASGNP HHQLAIVASY SRDEFVTTYR YFRSLAVEYP FPTARDNLIV AFDKNRQSYE KLFVPSKDSS KRLTGKGRGK GADISLKDAT 0301: LVAGPEKDKV TIANEMLKAF SIRFVHLNGI LFTRTSLETF FDVLASTSSS LREVISLGSA KELTLGIDTS DSALFIVRVV TMLIFSVHNS KKETEGQSYA 0401: EIVQRVEPAR NSLTASFELL GLVIEKCVQL GDPSSSYFLP GVLVFVEWLA CCPDIALGSD PDDRQTAVRN SFWNQFVVFF NQVLSLGPTF IDDVEDETCF 0501: SNMSLYDERE TENRLALWED YELRGFLPLL PAQTILNFSR KHSFGTEGPK EKKARIKRIF AAGKALTSVI KVDQNHVYFD SKKKKFLVGV KPADDFLDSH 0601: SSPPKACNAL QDNQVMIDHN SPIMQLDQQI YMGEEDDDDE VIVFKPLVTE KRKEASDQIY VPSGGFRKSD QVTTMGDFKA LSGSDVAFHE NQILQARGNA 0701: SIQVPASVGA NLLGPLQPST QSQAMHMQQV QTQVQVPASV GANLLGLLLT STQSQAMHMQ QVQTQAVNPQ PAQSLAASRL QPIQSQVAQP LPSRVVHFQQ 0801: TQAQVSHVSP AHSQSTSFGG GSKWSPEEAA SLASSLSGFA QLGNGHVMRN EMQGNHGVSY YPAHSLPVHQ SYNGNGMGGM PYSQSRTPEA VFPPKIDPVL 0901: SSGVVADGLG VQSSLAKKNP ISRAFRHLGP PPGFNSVPAK LQKEPAPGSE LSGNNHLPVD DYSWLDGYQA QSSRGVGLNS SLNYATSGKP EHLGSTGNGL 1001: NGPANFPFPG KQVPTSQVQA DFPYFQNPQK DNFVDKNHQS TQLPEQYQGQ STWSSRHFV |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)