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AT4G34640.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:18236008 (2008): endoplasmic reticulum
  • PMID:26781341 (2016): plasma membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:22923678 (2012): endoplasmic reticulum
  • PMID:21988472 (2012): plant-type vacuole plant-type vacuole membrane
  • PMID:19334764 (2009): plasma membrane
  • PMID:17644812 (2007): plasma membrane
  • PMID:16618929 (2006): endoplasmic reticulum
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : squalene synthase 1
Curator
Summary (TAIR10)
Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.
Computational
Description (TAIR10)
squalene synthase 1 (SQS1); FUNCTIONS IN: farnesyl-diphosphate farnesyltransferase activity; INVOLVED IN: sterol biosynthetic process; LOCATED IN: endoplasmic reticulum, plasma membrane, endoplasmic reticulum membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Squalene/phytoene synthase, conserved site (InterPro:IPR019845), Terpenoid synthase (InterPro:IPR008949), Farnesyl-diphosphate farnesyltransferase (InterPro:IPR006449), Squalene/phytoene synthase (InterPro:IPR002060); BEST Arabidopsis thaliana protein match is: squalene synthase 2 (TAIR:AT4G34650.1); Has 1469 Blast hits to 1468 proteins in 521 species: Archae - 28; Bacteria - 581; Metazoa - 114; Fungi - 174; Plants - 415; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G34640-MONOMERBioCyc:MetaCyc:AT4G34640-MONOMERBioGrid:14898BRENDA:2.5.1.21
EC:2.5.1.21eggNOG:COG1562eggNOG:KOG1459EMBL:AF004560
EMBL:AL023094EMBL:AL161585EMBL:AY099868EMBL:BT003419
EMBL:CP002687EMBL:D29017EMBL:U79159EMBL:X86692
EnsemblPlants:AT4G34640EnsemblPlants:AT4G34640.1entrez:829616Gene3D:1.10.600.10
GeneID:829616Genevisible:P53799GO:GO:0004310GO:GO:0005783
GO:GO:0005789GO:GO:0005886GO:GO:0008299GO:GO:0016021
GO:GO:0016126GO:GO:0016491GO:GO:0051996Gramene:AT4G34640.1
gramene_pathway:2.5.1.21gramene_pathway:PWY-5670gramene_plant_reactome:1119370gramene_plant_reactome:6873791
gramene_plant_reactome:6875407hmmpanther:PTHR11626hmmpanther:PTHR11626:SF2HOGENOM:HOG000186940
InParanoid:P53799IntAct:P53799InterPro:IPR002060InterPro:IPR006449
InterPro:IPR008949InterPro:IPR019845KEGG:00100+2.5.1.21KEGG:00909+2.5.1.21
KEGG:ath:AT4G34640KO:K00801OMA:ADLEWCYPaxDb:P53799
Pfam:P53799Pfam:PF00494PhylomeDB:P53799PIR:S54251
PRIDE:P53799PRO:PR:P53799PROSITE:PS01044PROSITE:PS01045
ProteinModelPortal:P53799Proteomes:UP000006548Reactome:R-ATH-191273RefSeq:NP_195190.1
scanprosite:PS01044scanprosite:PS01045SMR:P53799STRING:3702.AT4G34640.1
SUPFAM:SSF48576TAIR:AT4G34640tair10-symbols:ERG9tair10-symbols:SQS1
TIGRfam:TIGR01559TIGRFAMs:TIGR01559TMHMM:TMhelixUniGene:At.20898
UniGene:At.67805UniPathway:UPA00767UniProt:P53799
Coordinates (TAIR10) chr4:+:16538489..16541655
Molecular Weight (calculated) 47144.30 Da
IEP (calculated) 6.59
GRAVY (calculated) -0.13
Length 410 amino acids
Sequence (TAIR10)
(BLAST)
001: MGSLGTMLRY PDDIYPLLKM KRAIEKAEKQ IPPEPHWGFC YSMLHKVSRS FSLVIQQLNT ELRNAVCVFY LVLRALDTVE DDTSIPTDEK VPILIAFHRH
101: IYDTDWHYSC GTKEYKILMD QFHHVSAAFL ELEKGYQEAI EEITRRMGAG MAKFICQEVE TVDDYDEYCH YVAGLVGLGL SKLFLAAGSE VLTPDWEAIS
201: NSMGLFLQKT NIIRDYLEDI NEIPKSRMFW PREIWGKYAD KLEDLKYEEN TNKSVQCLNE MVTNALMHIE DCLKYMVSLR DPSIFRFCAI PQIMAIGTLA
301: LCYNNEQVFR GVVKLRRGLT AKVIDRTKTM ADVYGAFYDF SCMLKTKVDK NDPNASKTLN RLEAVQKLCR DAGVLQNRKS YVNDKGQPNS VFIIMVVILL
401: AIVFAYLRAN
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)