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AT3G06483.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
mitochondrion 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : pyruvate dehydrogenase kinase
Curator
Summary (TAIR10)
Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1α subunit of the pyruvate dehydrogenase complex (PDC) on a Ser residue using ATP as a phosphate donor. PDK is a unique type of protein kinase having a His-kinase-like sequence but Ser-kinase activity. Site-directed mutagenesis and structural analysis indicate that PDK belongs to the GHKL superfamily.
Computational
Description (TAIR10)
pyruvate dehydrogenase kinase (PDK); FUNCTIONS IN: ATP binding, pyruvate dehydrogenase (acetyl-transferring) kinase activity, histidine phosphotransfer kinase activity; INVOLVED IN: signal transduction, peptidyl-histidine phosphorylation, phosphorylation; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, core (InterPro:IPR005467), Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial (InterPro:IPR018955), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); Has 1925 Blast hits to 1799 proteins in 531 species: Archae - 0; Bacteria - 712; Metazoa - 467; Fungi - 468; Plants - 102; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G06483-MONOMERBRENDA:2.7.11.2EC:2.7.11.2eggNOG:COG0642
eggNOG:KOG0787EMBL:AC011623EMBL:AC020580EMBL:AF039406
EMBL:AJ007312EMBL:AY035017EMBL:AY059083EMBL:CP002686
EnsemblPlants:AT3G06483EnsemblPlants:AT3G06483.1entrez:819826Gene3D:1.20.140.20
Gene3D:3.30.565.10GeneID:819826Genevisible:Q9SBJ1GO:GO:0004740
GO:GO:0005524GO:GO:0005739GO:GO:0007165GO:GO:0009927
GO:GO:0042803GO:GO:0046777Gramene:AT3G06483.1hmmpanther:PTHR11947
hmmpanther:PTHR11947:SF24HOGENOM:HOG000164315InParanoid:Q9SBJ1InterPro:IPR003594
InterPro:IPR004358InterPro:IPR005467InterPro:IPR018955iPTMnet:Q9SBJ1
KEGG:ath:AT3G06483KO:K00898OMA:EKEFTQMPaxDb:Q9SBJ1
Pfam:PF02518Pfam:PF10436Pfam:Q9SBJ1Pfscan:PS50109
PhylomeDB:Q9SBJ1PIR:T51626PRIDE:Q9SBJ1PRINTS:PR00344
PRO:PR:Q9SBJ1PROSITE:PS50109ProteinModelPortal:Q9SBJ1Proteomes:UP000006548
Reactome:R-ATH-70895RefSeq:NP_187300.3SMART:SM00387SMR:Q9SBJ1
STRING:3702.AT3G06483.1SUPFAM:SSF55874SUPFAM:SSF69012TAIR:AT3G06483
tair10-symbols:ATPDHKtair10-symbols:PDKUniGene:At.10928UniProt:Q9SBJ1
Coordinates (TAIR10) chr3:-:1990727..1992581
Molecular Weight (calculated) 41449.30 Da
IEP (calculated) 7.12
GRAVY (calculated) -0.24
Length 366 amino acids
Sequence (TAIR10)
(BLAST)
001: MAVKKACEMF PKSLIEDVHK WGCMKQTGVS LRYMMEFGSK PTERNLLISA QFLHKELPIR VARRAIELQT LPYGLSDKPA VLKVRDWYLE SFRDMRAFPE
101: IKDSGDEKDF TQMIKAVKVR HNNVVPMMAL GVNQLKKGMN SGNLDEIHQF LDRFYLSRIG IRMLIGQHVE LHNPNPPLHT VGYIHTKMSP MEVARNASED
201: ARSICFREYG SAPEINIYGD PSFTFPYVPT HLHLMMYELV KNSLRAVQER FVDSDRVAPP IRIIVADGIE DVTIKVSDEG GGIARSGLPR IFTYLYSTAR
301: NPLEEDVDLG IADVPVTMAG YGYGLPISRL YARYFGGDLQ IISMEGYGTD AYLHLSRLGD SQEPLP
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)