AT3G06483.1
Subcellular Consensus
(Prediction and Experimental) min: :max .
SUBAcon:mitochondrion 1.000 What is SUBAcon? |
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Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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Description (TAIR10) | protein_coding : pyruvate dehydrogenase kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Curator Summary (TAIR10) |
Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1α subunit of the pyruvate dehydrogenase complex (PDC) on a Ser residue using ATP as a phosphate donor. PDK is a unique type of protein kinase having a His-kinase-like sequence but Ser-kinase activity. Site-directed mutagenesis and structural analysis indicate that PDK belongs to the GHKL superfamily. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Computational Description (TAIR10) |
pyruvate dehydrogenase kinase (PDK); FUNCTIONS IN: ATP binding, pyruvate dehydrogenase (acetyl-transferring) kinase activity, histidine phosphotransfer kinase activity; INVOLVED IN: signal transduction, peptidyl-histidine phosphorylation, phosphorylation; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, core (InterPro:IPR005467), Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial (InterPro:IPR018955), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); Has 1925 Blast hits to 1799 proteins in 531 species: Archae - 0; Bacteria - 712; Metazoa - 467; Fungi - 468; Plants - 102; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Protein Annotations |
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Coordinates (TAIR10) | chr3:-:1990727..1992581 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight (calculated) | 41449.30 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IEP (calculated) | 7.12 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GRAVY (calculated) | -0.24 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Length | 366 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence (TAIR10) (BLAST) |
001: MAVKKACEMF PKSLIEDVHK WGCMKQTGVS LRYMMEFGSK PTERNLLISA QFLHKELPIR VARRAIELQT LPYGLSDKPA VLKVRDWYLE SFRDMRAFPE 101: IKDSGDEKDF TQMIKAVKVR HNNVVPMMAL GVNQLKKGMN SGNLDEIHQF LDRFYLSRIG IRMLIGQHVE LHNPNPPLHT VGYIHTKMSP MEVARNASED 201: ARSICFREYG SAPEINIYGD PSFTFPYVPT HLHLMMYELV KNSLRAVQER FVDSDRVAPP IRIIVADGIE DVTIKVSDEG GGIARSGLPR IFTYLYSTAR 301: NPLEEDVDLG IADVPVTMAG YGYGLPISRL YARYFGGDLQ IISMEGYGTD AYLHLSRLGD SQEPLP |
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See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)