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AT1G68910.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:23396599 (2013): nucleus nuclear envelope nuclear inner membrane
  • PMID:19334764 (2009): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : WPP domain-interacting protein 2
Curator
Summary (TAIR10)
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
Computational
Description (TAIR10)
WPP domain-interacting protein 2 (WIT2); BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 1 (TAIR:AT5G11390.1); Has 80562 Blast hits to 45263 proteins in 2523 species: Archae - 1211; Bacteria - 12854; Metazoa - 37741; Fungi - 6730; Plants - 4174; Viruses - 347; Other Eukaryotes - 17505 (source: NCBI BLink).
Protein Annotations
BioGrid:28445eggNOG:ENOG410IIN4eggNOG:ENOG410YFHBEMBL:AC011665
EMBL:CP002684EnsemblPlants:AT1G68910EnsemblPlants:AT1G68910.1entrez:843224
GeneID:843224Genevisible:A8MQR0GO:GO:0016021hmmpanther:PTHR35705
hmmpanther:PTHR35705:SF2HOGENOM:HOG000084097InParanoid:A8MQR0IntAct:A8MQR0
KEGG:ath:AT1G68910ncoils:CoilOMA:KLHYTEQPaxDb:A8MQR0
Pfam:A8MQR0PhylomeDB:A8MQR0PIR:F96713PRIDE:A8MQR0
PRO:PR:A8MQR0ProteinModelPortal:A8MQR0Proteomes:UP000006548RefSeq:NP_001077797.1
RefSeq:NP_001185353.1RefSeq:NP_177057.2STRING:3702.AT1G68910.1SUPFAM:SSF57997
TAIR:AT1G68910tair10-symbols:WIT2TMHMM:TMhelixUniGene:At.35468
UniProt:A8MQR0
Coordinates (TAIR10) chr1:-:25908234..25910485
Molecular Weight (calculated) 71856.10 Da
IEP (calculated) 4.54
GRAVY (calculated) -0.58
Length 627 amino acids
Sequence (TAIR10)
(BLAST)
001: MEEIIREDYF EALSSRNEEE QEMLRMLTKL EIDSAYTSEK LMNLHVLLMH LLAWDNDLEG MGTLDSSPAS FEKALTFDLL CGILESEVKE VDEVLDVLEA
101: QIVDTSYKIS SCKHGNYIVI EGKLGESAES LKQSRGQVSE ITLQLAQLRR TLHYIRNGTS ENEESVELRQ KYALKPSDLR HKNALRMLEK SLSRELELEK
201: KLMEFQQNEE QLKLKLHYTE EVSSRMEEAS EFIWGRFLEA DNSSEVLTGI SKELVGRLQI LQFSLNGSAQ RESELKSKLE DCTVQLEAKD LLVQKLEGTI
301: SENSEIVSEV LTLREYVKSA EQKLKNTDLE LKSVNASKQE ILVHLAEMEN ANESVKENLF EAESRAESGE AKIKELDAAN LELTEELNFL KDADDKKTKK
401: VNSLEKQVRE LEVQVQNSKV SSEANQEQQN MLYSAIWDME TLIEDLKSKA SKAESRTETV EEQCIVLSTT NSELNKDVSF LRQKAKSLEA MLDLANNEKE
501: RYAQEITTRN KVLMDMMLQL SSERERIQEQ LYSLAKENKI LRVNQCSNTY QRNGSYAGDK ELSFHADGHE IEALAESLQE DERTREEPEK QSVSEKSSEI
601: RRAIKLKHIL VVALVFVLFC SFFGVTY
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)