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AT1G51660.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 0.998
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31520498 (2020): mitochondrion
  • PMID:28865150 (2017): extracellular region plant-type cell wall
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : mitogen-activated protein kinase kinase 4
Curator
Summary (TAIR10)
Encodes a mitogen-activated map kinase kinase (there are nine in Arabidopsis) involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK5. In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.
Computational
Description (TAIR10)
mitogen-activated protein kinase kinase 4 (MKK4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 5 (TAIR:AT3G21220.1); Has 131204 Blast hits to 129616 proteins in 4868 species: Archae - 124; Bacteria - 15116; Metazoa - 48947; Fungi - 12685; Plants - 32504; Viruses - 535; Other Eukaryotes - 21293 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT1G51660-MONOMERBioGrid:26816EC:2.7.12.2eggNOG:ENOG410XQ5A
eggNOG:KOG0581EMBL:AB015315EMBL:AC025294EMBL:AF324667
EMBL:AF326878EMBL:AF349517EMBL:AF375398EMBL:AY129469
EMBL:CP002684EnsemblPlants:AT1G51660EnsemblPlants:AT1G51660.1entrez:841591
GeneID:841591Genevisible:O80397GO:GO:0004674GO:GO:0005524
GO:GO:0005634GO:GO:0005737GO:GO:0007346GO:GO:0009570
GO:GO:0009626GO:GO:0009814GO:GO:0010227GO:GO:0010229
GO:GO:0031098Gramene:AT1G51660.1hmmpanther:PTHR24361hmmpanther:PTHR24361:SF319
HOGENOM:HOG000234206InParanoid:O80397IntAct:O80397InterPro:IPR000719
InterPro:IPR008271InterPro:IPR011009InterPro:IPR017441iPTMnet:O80397
KEGG:ath:AT1G51660KO:K13413OMA:HIATEPLPaxDb:O80397
Pfam:O80397Pfam:PF00069Pfscan:PS50011PhylomeDB:O80397
PIR:T51339PRIDE:O80397PRO:PR:O80397PROSITE:PS00107
PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:O80397Proteomes:UP000006548
Reactome:R-ATH-110056Reactome:R-ATH-112411Reactome:R-ATH-2559580Reactome:R-ATH-445144
Reactome:R-ATH-450302Reactome:R-ATH-450321Reactome:R-ATH-5674135Reactome:R-ATH-5674499
RefSeq:NP_175577.1scanprosite:PS00107scanprosite:PS00108SMART:SM00220
SMR:O80397STRING:3702.AT1G51660.1SUPFAM:SSF56112TAIR:AT1G51660
tair10-symbols:ATMEK4tair10-symbols:ATMKK4tair10-symbols:MKK4UniGene:At.351
UniProt:O80397
Coordinates (TAIR10) chr1:+:19154575..19155675
Molecular Weight (calculated) 40119.00 Da
IEP (calculated) 9.70
GRAVY (calculated) -0.38
Length 366 amino acids
Sequence (TAIR10)
(BLAST)
001: MRPIQSPPGV SVPVKSRPRR RPDLTLPLPQ RDVSLAVPLP LPPTSGGSGG SSGSAPSSGG SASSTNTNSS IEAKNYSDLV RGNRIGSGAG GTVYKVIHRP
101: SSRLYALKVI YGNHEETVRR QICREIEILR DVNHPNVVKC HEMFDQNGEI QVLLEFMDKG SLEGAHVWKE QQLADLSRQI LSGLAYLHSR HIVHRDIKPS
201: NLLINSAKNV KIADFGVSRI LAQTMDPCNS SVGTIAYMSP ERINTDLNQG KYDGYAGDIW SLGVSILEFY LGRFPFPVSR QGDWASLMCA ICMSQPPEAP
301: ATASPEFRHF ISCCLQREPG KRRSAMQLLQ HPFILRASPS QNRSPQNLHQ LLPPPRPLSS SSSPTT
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)