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AT4G21070.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : breast cancer susceptibility1
Curator
Summary (TAIR10)
Encodes AtBRCA1, an ortholog of the human breast cancer susceptibility gene 1. Contains one N-terminal RING finger, two C-terminal BRCT and the p300/CBP interacting domain. Strongly induced by gamma rays, consistent with a putative role in DNA repair and in cell cycle control.
Computational
Description (TAIR10)
breast cancer susceptibility1 (BRCA1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: DNA repair, response to gamma radiation; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), BRCA1 (InterPro:IPR011364), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer associated RING 1 (TAIR:AT1G04020.2); Has 8999 Blast hits to 8407 proteins in 1134 species: Archae - 0; Bacteria - 191; Metazoa - 6557; Fungi - 520; Plants - 721; Viruses - 32; Other Eukaryotes - 978 (source: NCBI BLink).
Protein Annotations
BioGrid:13145eggNOG:ENOG410ITQ6eggNOG:ENOG4111WR7EMBL:AF515728EMBL:AL080282EMBL:AL161554EMBL:AY081328
EMBL:BT010547EMBL:CP002687EnsemblPlants:AT4G21070EnsemblPlants:AT4G21070.1entrez:827854Gene3D:3.30.40.10Gene3D:3.40.50.10190
GeneID:827854Genevisible:Q8RXD4GO:GO:0000724GO:GO:0004842GO:GO:0005634GO:GO:0005886GO:GO:0006281
GO:GO:0006310GO:GO:0008270GO:GO:0010332GO:GO:0016567GO:GO:0031436GO:GO:0035066GO:GO:0035067
GO:GO:0042127GO:GO:0045717GO:GO:0045944GO:GO:0070531GO:GO:0071158GO:GO:0071480Gramene:AT4G21070.1
hmmpanther:PTHR13763hmmpanther:PTHR13763:SF1HOGENOM:HOG000084100InParanoid:Q8RXD4InterPro:IPR001357InterPro:IPR001841InterPro:IPR013083
InterPro:IPR017907InterPro:IPR031099iPTMnet:Q8RXD4KEGG:00220+6.3.2.-KEGG:00261+6.3.2.-KEGG:00380+6.3.2.-KEGG:ath:AT4G21070
KO:K10683MINT:MINT-3289893ncoils:CoilOMA:IMKPEEPPANTHER:PTHR13763PaxDb:Q8RXD4Pfam:PF00533
Pfam:PF13771Pfam:PF13920Pfam:PF16589Pfam:Q8RXD4Pfscan:PS50089Pfscan:PS50172PhylomeDB:Q8RXD4
PRIDE:Q8RXD4PRO:PR:Q8RXD4PROSITE:PS00518PROSITE:PS50089PROSITE:PS50172ProteinModelPortal:Q8RXD4Proteomes:UP000006548
Reactome:R-ATH-3108214RefSeq:NP_193839.4scanprosite:PS00518SMART:SM00184SMART:SM00292SMR:Q8RXD4STRING:3702.AT4G21070.1
SUPFAM:SSF52113SUPFAM:SSF57850TAIR:AT4G21070tair10-symbols:ATBRCA1tair10-symbols:BRCA1UniGene:At.32665UniProt:Q8RXD4
Coordinates (TAIR10) chr4:+:11248174..11252633
Molecular Weight (calculated) 103927.00 Da
IEP (calculated) 9.41
GRAVY (calculated) -0.68
Length 941 amino acids
Sequence (TAIR10)
(BLAST)
001: MADTSHLERM GRELKCPICL SLYNSAVSLS CNHVFCNACI VKSMKMDATC PVCKIPYHRR EIRGAPHMDS LVSIYKNMED ASGIKLFVSQ NNPSPSDKEK
101: QVRDASVEKA SDKNRQGSRK GRASKRNEYG KTKEIDVDAP GPIVMKPSSQ TKKRVQLLQN LSAESLTKPT ESVETAEKPK DYTENTVIRL DEHPSLNKEG
201: NLSPFFWLRD EDDGENSSQR TESDQLLGTT PVNVPSFSDL MDSDHESPSK EDEQQKPNPG DMFDSEMFEW TQRPCSPEIL PSPVKAKVLG RDEIDLTQKK
301: LPKVKVASSK CKNRKAGSAR NTVARRSIGV SQEDNMESSA AATISEQQDS RGTSGTIIRN DVNTDENVKA KRATRSKAQS TRVQSDLNVS NEADGKQGTK
401: RKRSSIKSSP AHPIAGPNEL SLGTEIVGKG DQDQAHGPSD THPEKRSPTE KPSLKKRGRK SNASSSLKDL SGKTQKKTSE KKLKLDSHMI SSKATQPHGN
501: GILTAGLNQG GDKQDSRNNR KSTVGKDDHT MQVIEKCSTI NKSSSGGSAH LRRCNGSLTK KFTCAFCQCS EDTEASGEMT HYYRGEPVSA DFNGGSKVIH
601: VHKNCAEWAP NVYFNDLTIV NLDVELTRSR RISCSCCGLK GAALGCYNKS CKNSFHVTCA KLIPECRWDN VKFVMLCPLD ASIKLPCEEA NSKDRKCKRT
701: PKEPLHSQPK QVSGKANIRE LHIKQFHGFS KKLVLSCSGL TVEEKTVIAE FAELSGVTIS KNWDSTVTHV IASINENGAC KRTLKFMMAI LEGKWILTID
801: WIKACMKNTK YVSEEPYEIT MDVHGIREGP YLGRQRALKK KPKLFTGLKF YIMGDFELAY KGYLQDLIVA AGGTILRRRP VSSDDNEAST IVVFSVEPSK
901: KKTLTQRRSD AEALAKSARA RAASSSWVLD SIAGCQILVL I
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)