AT1G08260.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 ASURE: nucleus What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : DNA polymerase epsilon catalytic subunit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr1:+:2590944..2606892 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 248910.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 6.55 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.38 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 2161 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT FSSSSWEDRD TGKVYSCVDL YFVTQDGFSF KTKYKFRPYF YAATKDKMEL 0101: ELEAYLRRRY ERQVADIEIV EKEDLDLKNH LSGLQKKYLK ISFDTVQQLM EVKRDLLHIV ERNQAKFDAL EAYESILAGK REQRPQDCLD SIVDLREYDV 0201: PYHVRFAIDN DVRSGQWYNV SISSTDVILE KRTDLLQRAE VRVCAFDIET TKLPLKFPDA EYDQIMMISY MVDGQGFLII NRECVGEDVE DLEYTPKPEF 0301: EGYFKVTNVK NEVELLQRWF YHMQELKPGI YVTYNGDFFD WPFIERRASH HGIKMNEELG FRCDQNQGEC RAKFACHLDC FAWVKRDSYL PQGSHGLKAV 0401: TKAKLGYDPL EVNPEDMVRF AMEKPQTMAS YSVSDAVATY YLYMTYVNPF IFSLATIIPM VPDEVLRKGS GTLCEMLLMV EAYKANVVCP NKNQADPEKF 0501: YQNQLLESET YIGGHVECLE SGVFRSDIPT SFKLDSSAYQ QLIDNLGRDL EYAITVEGKM RMDSISNYDE VKDEIKEKLE KLRDDPIREE GPLIYHLDVA 0601: AMYPNIILTN RLQPPSIVTD EICTACDFNR PGKTCLRKLE WVWRGVTFMG KKSDYYHLKK QIESEFVDAG ANIMSSKSFL DLPKVDQQSK LKERLKKYCQ 0701: KAYKRVLDKP ITEVREAGIC MRENPFYVDT VRSFRDRRYE YKTLNKVWKG KLSEAKASGN SIKIQEAQDM VVVYDSLQLA HKCILNSFYG YVMRKGARWY 0801: SMEMAGVVTY TGAKIIQNAR LLIERIGKPL ELDTDGIWCC LPGSFPENFT FKTIDMKKLT ISYPCVMLNV DVAKNNTNDQ YQTLVDPVRK TYKSHSECSI 0901: EFEVDGPYKA MIIPASKEEG ILIKKRYAVF NHDGTLAELK GFEIKRRGEL KLIKVFQAEL FDKFLHGSTL EECYSAVAAV ADRWLDLLDN QGKDIADSEL 1001: LDYISESSTM SKSLADYGEQ KSCAVTTAKR LAEFLGVTMV KDKGLRCQYI VACEPKGTPV SERAVPVAIF TTNPEVMKFH LRKWCKTSSD VGIRLIIDWS 1101: YYKQRLSSAI QKVITIPAAM QKVANPVPRV LHPDWLHKKV REKDDKFRQR KLVDMFSSAN KDVVLDTDLP VTKDNVEDIE DFCKENRPSV KGPKPIARSY 1201: EVNKKQSECE QQESWDTEFH DISFQNIDKS VNYQGWLELK KRKWKVTLEK KKKRRLGDLR SSNQVDTHEI NQKVGQGRGG VGSYFRRPEE ALTSSHWQII 1301: QLVPSPQSGQ FFAWVVVEGL MLKIPLSIPR VFYINSKVPI DEYFQGKCVN KILPHGRPCY SLTEVKIQED QFKKESKKRA ALLADPGVEG IYETKVPLEF 1401: SAICQIGCVC KIDNKAKHRN TQDGWEVGEL HMKTTTECHY LKRSIPLVYL YNSTSTGRAI YVLYCHVSKL MSAVVVDPFN GNELLPSALE RQFRDSCLEL 1501: SLDSLSWDGI RFQVHYVDHP EAAKKIIQRA ISEYREENCG PTVAVIECPD FTFMKEGIKA LDDFPCVRIP FNDDDNSYQP VSWQRPAAKI AMFRCAAAFQ 1601: WLDRRITQSR YAHVPLGNFG LDWLTFTIDI FLSRALRDQQ QVLWVSDNGV PDLGGINNEE AFFADEVQQT SLVFPGAYRK VSVELKIHNL AVNALLKSNL 1701: VNEMEGGGFM GFEQDVNPRG INSNDNTSFD ETTGCAQAFR VLKQLIHSCL TDVRKSKNIY ADSILQRLSW WLCSPSSKLH DPALHLMLHK VMQKVFALLL 1801: TDLRRLGAII IYADFSKVII DTVKFDLSAA KAYCESLLST VRNSDIFEWI LLEPVHYWHS LLFMDQYNYA GIRADDEISL DEVTIEPKWS VARHLPEYIE 1901: RDFIIIIAKF IFDPWKFAIE NKKGSSESLE AQMIEYLREQ IGSTFINMLV KKVDDIMSHM KEINVSDASR VSGQAPKGDY SLEFIQVISA VLALDQNVQQ 2001: DVLVMRKSLL KYIKVKECAA EAEFLDPGPS FILPNVACSN CDAYRDLDIC RDPALLTEKE WSCADTQCGK IYDREQMESS LLEMVRQRER MYHMQDVVCI 2101: RCNQVKAAHL TEQCECSGSF RCKESGSEFS KRMEIFMDIA KRQKFRLLEE YISWIIYGPS Y |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)