AT5G04560.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 ASURE: nucleus What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : HhH-GPD base excision DNA repair family protein | ||||||||||||
| Curator Summary (TAIR10) |
Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele. | ||||||||||||
| Computational Description (TAIR10) |
DEMETER (DME); CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: demeter-like 1 (TAIR:AT2G36490.1); Has 3638 Blast hits to 3482 proteins in 1335 species: Archae - 238; Bacteria - 2315; Metazoa - 178; Fungi - 96; Plants - 343; Viruses - 0; Other Eukaryotes - 468 (source: NCBI BLink). | ||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:1310671..1318091 | ||||||||||||
| Molecular Weight (calculated) | 192915.00 Da | ||||||||||||
| IEP (calculated) | 8.14 | ||||||||||||
| GRAVY (calculated) | -0.76 | ||||||||||||
| Length | 1729 amino acids | ||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MQSIMDSSAV NATEATEQND GSRQDVLEFD LNKTPQQKPS KRKRKFMPKV VVEGKPKRKP RKPAELPKVV VEGKPKRKPR KAATQEKVKS KETGSAKKKN 0101: LKESATKKPA NVGDMSNKSP EVTLKSCRKA LNFDLENPGD ARQGDSESEI VQNSSGANSF SEIRDAIGGT NGSFLDSVSQ IDKTNGLGAM NQPLEVSMGN 0201: QPDKLSTGAK LARDQQPDLL TRNQQCQFPV ATQNTQFPME NQQAWLQMKN QLIGFPFGNQ QPRMTIRNQQ PCLAMGNQQP MYLIGTPRPA LVSGNQQLGG 0301: PQGNKRPIFL NHQTCLPAGN QLYGSPTDMH QLVMSTGGQQ HGLLIKNQQP GSLIRGQQPC VPLIDQQPAT PKGFTHLNQM VATSMSSPGL RPHSQSQVPT 0401: TYLHVESVSR ILNGTTGTCQ RSRAPAYDSL QQDIHQGNKY ILSHEISNGN GCKKALPQNS SLPTPIMAKL EEARGSKRQY HRAMGQTEKH DLNLAQQIAQ 0501: SQDVERHNSS TCVEYLDAAK KTKIQKVVQE NLHGMPPEVI EIEDDPTDGA RKGKNTASIS KGASKGNSSP VKKTAEKEKC IVPKTPAKKG RAGRKKSVPP 0601: PAHASEIQLW QPTPPKTPLS RSKPKGKGRK SIQDSGKARG PSGELLCQDS IAEIIYRMQN LYLGDKEREQ EQNAMVLYKG DGALVPYESK KRKPRPKVDI 0701: DDETTRIWNL LMGKGDEKEG DEEKDKKKEK WWEEERRVFR GRADSFIARM HLVQGDRRFS PWKGSVVDSV IGVFLTQNVS DHLSSSAFMS LAARFPPKLS 0801: SSREDERNVR SVVVEDPEGC ILNLNEIPSW QEKVQHPSDM EVSGVDSGSK EQLRDCSNSG IERFNFLEKS IQNLEEEVLS SQDSFDPAIF QSCGRVGSCS 0901: CSKSDAEFPT TRCETKTVSG TSQSVQTGSP NLSDEICLQG NERPHLYEGS GDVQKQETTN VAQKKPDLEK TMNWKDSVCF GQPRNDTNWQ TTPSSSYEQC 1001: ATRQPHVLDI EDFGMQGEGL GYSWMSISPR VDRVKNKNVP RRFFRQGGSV PREFTGQIIP STPHELPGMG LSGSSSAVQE HQDDTQHNQQ DEMNKASHLQ 1101: KTFLDLLNSS EECLTRQSST KQNITDGCLP RDRTAEDVVD PLSNNSSLQN ILVESNSSNK EQTAVEYKET NATILREMKG TLADGKKPTS QWDSLRKDVE 1201: GNEGRQERNK NNMDSIDYEA IRRASISEIS EAIKERGMNN MLAVRIKDFL ERIVKDHGGI DLEWLRESPP DKAKDYLLSI RGLGLKSVEC VRLLTLHNLA 1301: FPVDTNVGRI AVRMGWVPLQ PLPESLQLHL LELYPVLESI QKFLWPRLCK LDQRTLYELH YQLITFGKVF CTKSRPNCNA CPMRGECRHF ASAYASARLA 1401: LPAPEERSLT SATIPVPPES YPPVAIPMIE LPLPLEKSLA SGAPSNRENC EPIIEEPASP GQECTEITES DIEDAYYNED PDEIPTIKLN IEQFGMTLRE 1501: HMERNMELQE GDMSKALVAL HPTTTSIPTP KLKNISRLRT EHQVYELPDS HRLLDGMDKR EPDDPSPYLL AIWTPGETAN SAQPPEQKCG GKASGKMCFD 1601: ETCSECNSLR EANSQTVRGT LLIPCRTAMR GSFPLNGTYF QVNELFADHE SSLKPIDVPR DWIWDLPRRT VYFGTSVTSI FRGLSTEQIQ FCFWKGFVCV 1701: RGFEQKTRAP RPLMARLHFP ASKLKNNKT |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)