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AT5G11670.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31871212 (2020): mitochondrion
  • PMID:31520498 (2020): mitochondrion
  • PMID:31186290 (2019): cytosol None
  • PMID:31023727 (2019): mitochondrion
  • PMID:30962257 (2019): plastid
  • PMID:30783145 (2019): extracellular region plant-type cell wall
  • PMID:30447334 (2019): plasma membrane
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:27122571 (2016): mitochondrion
  • PMID:26781341 (2016): plasma membrane
  • PMID:26572690 (2016): extracellular region plant-type cell wall
  • PMID:25641898 (2015): plasma membrane
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:24124904 (2013): plastid
  • PMID:23903016 (2013): plant-type vacuole plant-type vacuole membrane
  • PMID:23673981 (2013): plastid plastid stroma plastoglobules
  • PMID:22550958 (2012): plastid
  • PMID:22215637 (2012): plasma membrane
  • PMID:21533090 (2011): extracellular region plant-type cell wall
  • PMID:21433285 (2011): plasma membrane
  • PMID:21166475 (2011): cytosol
  • PMID:19334764 (2009): plasma membrane
  • PMID:17644812 (2007): plasma membrane
  • PMID:17317660 (2007): plasma membrane
  • PMID:17151019 (2007): plant-type vacuole
  • PMID:15028209 (2004): plastid
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : NADP-malic enzyme 2
Curator
Summary (TAIR10)
The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME2 is presumably a cytosolic enzyme involved in malate metabolism and possibly assisting the oxidative pentose phosphate pathway. AtNADP-ME2 counts for the major part of NADP-ME activity in mature tissues of Arabidopsis.
Computational
Description (TAIR10)
NADP-malic enzyme 2 (NADP-ME2); FUNCTIONS IN: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity, oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity; INVOLVED IN: response to cadmium ion, malate metabolic process, pentose-phosphate shunt, oxidative branch, protein homooligomerization; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 3 (TAIR:AT5G25880.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G11670-MONOMERBRENDA:1.1.1.40EC:1.1.1.40eggNOG:COG0281
eggNOG:KOG1257EMBL:AF428407EMBL:AK317577EMBL:AK317669
EMBL:AL163814EMBL:CP002688EnsemblPlants:AT5G11670EnsemblPlants:AT5G11670.1
entrez:831039Gene3D:3.40.50.10380Gene3D:3.40.50.720GeneID:831039
Genevisible:Q9LYG3GO:GO:0004471GO:GO:0004473GO:GO:0005618
GO:GO:0005774GO:GO:0005829GO:GO:0005886GO:GO:0006108
GO:GO:0008948GO:GO:0009051GO:GO:0009506GO:GO:0009507
GO:GO:0016020GO:GO:0046686GO:GO:0046872GO:GO:0048046
GO:GO:0051260GO:GO:0051287Gramene:AT5G11670.1hmmpanther:PTHR23406
hmmpanther:PTHR23406:SF31HOGENOM:HOG000042486InParanoid:Q9LYG3IntAct:Q9LYG3
InterPro:IPR001891InterPro:IPR012301InterPro:IPR012302InterPro:IPR015884
InterPro:IPR016040iPTMnet:Q9LYG3KEGG:ath:AT5G11670KO:K00029
OMA:CINTNDPPaxDb:Q9LYG3Pfam:PF00390Pfam:PF03949
Pfam:Q9LYG3PhylomeDB:Q9LYG3PIR:T48526PIRSF:PIRSF000106
PRIDE:Q9LYG3PRINTS:PR00072PRO:PR:Q9LYG3ProMEX:Q9LYG3
PROSITE:PS00331ProteinModelPortal:Q9LYG3Proteomes:UP000006548RefSeq:NP_196728.1
SABIO-RK:Q9LYG3scanprosite:PS00331SMART:SM00919SMART:SM01274
SMR:Q9LYG3STRING:3702.AT5G11670.1SUPFAM:SSF51735SUPFAM:SSF53223
TAIR:AT5G11670tair10-symbols:ATNADP-ME2tair10-symbols:NADP-ME2UniGene:At.5113
UniProt:Q9LYG3
Coordinates (TAIR10) chr5:+:3754456..3758040
Molecular Weight (calculated) 64416.50 Da
IEP (calculated) 6.37
GRAVY (calculated) -0.12
Length 588 amino acids
Sequence (TAIR10)
(BLAST)
001: MGSTPTDLPG EDVADNRSGV GGGISDVYGE DSATLDQLVT PWVTSVASGY TLMRDPRYNK GLAFTDKERD AHYLTGLLPP VILSQDVQER KVMHNLRQYT
101: VPLQRYMALM DLQERNERLF YKLLIDNVEE LLPVVYTPTV GEACQKYGSI FRKPQGLYIS LNEKGKILEV LKNWPQRGIQ VIVVTDGERI LGLGDLGCQG
201: MGIPVGKLSL YTALGGIRPS ACLPITIDVG TNNEKLLNDE FYIGLKQRRA TGQEYAEFLH EFMCAVKQNY GEKVLVQFED FANHNAFDLL SKYSDSHLVF
301: NDDIQGTASV VLAGLIAAQK VLGKKLADHT FLFLGAGEAG TGIAELIALK ISKETGAPIT ETRKKIWLVD SKGLIVSSRK ESLQHFKQPW AHEHKPVKDL
401: IGAVNAIKPT VLIGTSGVGQ TFTKEVVEAM ATNNEKPLIL ALSNPTSQAE CTAEQAYTWT KGRAIFGSGS PFDPVVYDGK TYLPGQANNC YIFPGLGLGL
501: IMSGAIRVRD DMLLAASEAL AAQVTEEHYA NGLIYPPFSN IREISANIAA CVAAKTYDLG LASNLPRAKD LVKFAESSMY SPVYRNYR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)