suba logo
AT5G04560.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

.
SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : HhH-GPD base excision DNA repair family protein
Curator
Summary (TAIR10)
Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele.
Computational
Description (TAIR10)
DEMETER (DME); CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: demeter-like 1 (TAIR:AT2G36490.1); Has 3638 Blast hits to 3482 proteins in 1335 species: Archae - 238; Bacteria - 2315; Metazoa - 178; Fungi - 96; Plants - 343; Viruses - 0; Other Eukaryotes - 468 (source: NCBI BLink).
Protein Annotations
EnsemblPlants:AT5G04560EnsemblPlants:AT5G04560.1entrez:830335hmmpanther:PTHR10359
hmmpanther:PTHR10359:SF28ncoils:CoilPfam:PF15628Pfam:PF15629
tair10-symbols:DME
Coordinates (TAIR10) chr5:+:1310671..1318091
Molecular Weight (calculated) 192915.00 Da
IEP (calculated) 8.14
GRAVY (calculated) -0.76
Length 1729 amino acids
Sequence (TAIR10)
(BLAST)
0001: MQSIMDSSAV NATEATEQND GSRQDVLEFD LNKTPQQKPS KRKRKFMPKV VVEGKPKRKP RKPAELPKVV VEGKPKRKPR KAATQEKVKS KETGSAKKKN
0101: LKESATKKPA NVGDMSNKSP EVTLKSCRKA LNFDLENPGD ARQGDSESEI VQNSSGANSF SEIRDAIGGT NGSFLDSVSQ IDKTNGLGAM NQPLEVSMGN
0201: QPDKLSTGAK LARDQQPDLL TRNQQCQFPV ATQNTQFPME NQQAWLQMKN QLIGFPFGNQ QPRMTIRNQQ PCLAMGNQQP MYLIGTPRPA LVSGNQQLGG
0301: PQGNKRPIFL NHQTCLPAGN QLYGSPTDMH QLVMSTGGQQ HGLLIKNQQP GSLIRGQQPC VPLIDQQPAT PKGFTHLNQM VATSMSSPGL RPHSQSQVPT
0401: TYLHVESVSR ILNGTTGTCQ RSRAPAYDSL QQDIHQGNKY ILSHEISNGN GCKKALPQNS SLPTPIMAKL EEARGSKRQY HRAMGQTEKH DLNLAQQIAQ
0501: SQDVERHNSS TCVEYLDAAK KTKIQKVVQE NLHGMPPEVI EIEDDPTDGA RKGKNTASIS KGASKGNSSP VKKTAEKEKC IVPKTPAKKG RAGRKKSVPP
0601: PAHASEIQLW QPTPPKTPLS RSKPKGKGRK SIQDSGKARG PSGELLCQDS IAEIIYRMQN LYLGDKEREQ EQNAMVLYKG DGALVPYESK KRKPRPKVDI
0701: DDETTRIWNL LMGKGDEKEG DEEKDKKKEK WWEEERRVFR GRADSFIARM HLVQGDRRFS PWKGSVVDSV IGVFLTQNVS DHLSSSAFMS LAARFPPKLS
0801: SSREDERNVR SVVVEDPEGC ILNLNEIPSW QEKVQHPSDM EVSGVDSGSK EQLRDCSNSG IERFNFLEKS IQNLEEEVLS SQDSFDPAIF QSCGRVGSCS
0901: CSKSDAEFPT TRCETKTVSG TSQSVQTGSP NLSDEICLQG NERPHLYEGS GDVQKQETTN VAQKKPDLEK TMNWKDSVCF GQPRNDTNWQ TTPSSSYEQC
1001: ATRQPHVLDI EDFGMQGEGL GYSWMSISPR VDRVKNKNVP RRFFRQGGSV PREFTGQIIP STPHELPGMG LSGSSSAVQE HQDDTQHNQQ DEMNKASHLQ
1101: KTFLDLLNSS EECLTRQSST KQNITDGCLP RDRTAEDVVD PLSNNSSLQN ILVESNSSNK EQTAVEYKET NATILREMKG TLADGKKPTS QWDSLRKDVE
1201: GNEGRQERNK NNMDSIDYEA IRRASISEIS EAIKERGMNN MLAVRIKDFL ERIVKDHGGI DLEWLRESPP DKAKDYLLSI RGLGLKSVEC VRLLTLHNLA
1301: FPVDTNVGRI AVRMGWVPLQ PLPESLQLHL LELYPVLESI QKFLWPRLCK LDQRTLYELH YQLITFGKVF CTKSRPNCNA CPMRGECRHF ASAYASARLA
1401: LPAPEERSLT SATIPVPPES YPPVAIPMIE LPLPLEKSLA SGAPSNRENC EPIIEEPASP GQECTEITES DIEDAYYNED PDEIPTIKLN IEQFGMTLRE
1501: HMERNMELQE GDMSKALVAL HPTTTSIPTP KLKNISRLRT EHQVYELPDS HRLLDGMDKR EPDDPSPYLL AIWTPGETAN SAQPPEQKCG GKASGKMCFD
1601: ETCSECNSLR EANSQTVRGT LLIPCRTAMR GSFPLNGTYF QVNELFADHE SSLKPIDVPR DWIWDLPRRT VYFGTSVTSI FRGLSTEQIQ FCFWKGFVCV
1701: RGFEQKTRAP RPLMARLHFP ASKLKNNKT
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)