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AT4G34570.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
mitochondrion 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : thymidylate synthase 2
Curator
Summary (TAIR10)
Encodes a bifunctional dihydrofolate reductase - thymidylate synthase gene. This is unique in Arabidopsis and protozoa. Other organisms have independent genes for this function.
Computational
Description (TAIR10)
thymidylate synthase 2 (THY-2); CONTAINS InterPro DOMAIN/s: Thymidylate synthase, active site (InterPro:IPR020940), Dihydrofolate reductase domain (InterPro:IPR001796), Dihydrofolate reductase conserved site (InterPro:IPR017925), Bifunctional dihydrofolate reductase/thymidylate synthase (InterPro:IPR012262), Thymidylate synthase (InterPro:IPR000398); BEST Arabidopsis thaliana protein match is: thymidylate synthase 1 (TAIR:AT2G16370.1); Has 13567 Blast hits to 13544 proteins in 2627 species: Archae - 73; Bacteria - 8801; Metazoa - 517; Fungi - 428; Plants - 92; Viruses - 256; Other Eukaryotes - 3400 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G34570-MONOMEREC:1.5.1.3EC:2.1.1.45eggNOG:COG0207
eggNOG:COG0262eggNOG:KOG0673eggNOG:KOG1324EMBL:AK227728
EMBL:AL023094EMBL:AL161585EMBL:BT003159EMBL:CP002687
EMBL:L08594EnsemblPlants:AT4G34570EnsemblPlants:AT4G34570.1entrez:829609
Gene3D:3.30.572.10Gene3D:3.40.430.10GeneID:829609Genevisible:Q05763
GO:GO:0004146GO:GO:0004799GO:GO:0006231GO:GO:0006545
GO:GO:0006730GO:GO:0009257Gramene:AT4G34570.1gramene_pathway:1.5.1.3
gramene_pathway:2.1.1.45gramene_pathway:PWY-3742gramene_pathway:PWY-3841gramene_pathway:PWY0-166
HAMAP:MF_00008hmmpanther:PTHR11548hmmpanther:PTHR11548:SF2HOGENOM:HOG000257901
InParanoid:Q05763InterPro:IPR000398InterPro:IPR001796InterPro:IPR012262
InterPro:IPR017925InterPro:IPR020940InterPro:IPR023451InterPro:IPR024072
KEGG:00240+2.1.1.45KEGG:00670+1.5.1.3KEGG:00670+1.5.1.3+2.1.1.45KEGG:00670+2.1.1.45
KEGG:00790+1.5.1.3KEGG:ath:AT4G34570KO:K13998OMA:HVCGLSP
PaxDb:Q05763Pfam:PF00186Pfam:PF00303Pfam:Q05763
Pfscan:PS51330PhylomeDB:Q05763PIR:T05277PIRSF:PIRSF000389
PRIDE:Q05763PRINTS:PR00108PRO:PR:Q05763PROSITE:PS00075
PROSITE:PS00091PROSITE:PS51330ProteinModelPortal:Q05763Proteomes:UP000006548
Reactome:R-ATH-113510Reactome:R-ATH-500753Reactome:R-ATH-69205RefSeq:NP_195183.2
scanprosite:PS00075scanprosite:PS00091SMR:Q05763STRING:3702.AT4G34570.1
SUPFAM:SSF53597SUPFAM:SSF55831TAIR:AT4G34570tair10-symbols:THY-2
TIGRfam:TIGR03284TIGRFAMs:TIGR03284UniGene:At.31491UniPathway:UPA00077
unipathway:UPA00575UniProt:Q05763
Coordinates (TAIR10) chr4:-:16511129..16514110
Molecular Weight (calculated) 63212.10 Da
IEP (calculated) 8.01
GRAVY (calculated) -0.20
Length 565 amino acids
Sequence (TAIR10)
(BLAST)
001: MRCLQNSAKT LPLAFKSALL PLSQRWFCKF SPKPSSLTNI FKVSISTMAN TLNGNVIMTS KPQSTYQVVV AATKEMGIGK DGKLPWNLPT DLKFFKDLTL
101: STSDSAKKNA VVMGRKTWES IPKKYRPLSG RLNVVLSRSS GFDIANTENV VTCSSIDSAL DLLAAPPFSL SIEKVFVIGG GDILREALNK PSCEAIHITE
201: IDTSIDCDTF IPTVDTSAYQ PWCSSFPICE NGLRFSFTTH VRVKSSSAGE ASDESDGSKV LQVDWKKFSS VLPKMIFDRH EEYLYLNLVK EIISNGNLKD
301: DRTGTGTLSK FGCQMKFNLR RNFPLLTTKR VFWRGVVEEL LWFISGSTNA KVLQEKGIRI WDGNASRAYL DGIGLTEREE GDLGPVYGFQ WRHFGAKYTD
401: MHADYTGQGF DQLLDVINKI KNNPDDRRII MSAWNPSDLK LMALPPCHMF AQFYVANGEL SCQMYQRSAD MGLGVPFNIA SYSLLTCILA HVCDLVPGDF
501: IHVIGDAHVY KNHVRPLQEQ LENPPKPFPV LKINPEKKDI DSFVADDFEL IGYDPHKKID MKMAV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)