AT5G60600.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:plastid 1.000 ASURE: plastid What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : 4-hydroxy-3-methylbut-2-enyl diphosphate synthase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes a chloroplast-localized hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) synthase (HDS), catalyzes the formation of HMBPP from 2-C-methyl-D-erythrytol 2,4-cyclodiphosphate (MEcPP). The HDS enzyme controls the penultimate steps of the biosynthesis of IPP and dimethylallyl diphosphate (DMAPP) via the MEP pathway and may serve as a metabolic control point for SA-mediated disease resistance. In the light, the electrons required for the reaction catalyzed by HDS are directly provided by the electron flow from photosynthesis via ferredoxin. In the dark however, the enzyme requires an electron shuttle: ferredoxin-NADP<sup>+</sup> reductase. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
4-hydroxy-3-methylbut-2-enyl diphosphate synthase (HDS); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity, 4 iron, 4 sulfur cluster binding; INVOLVED IN: response to light stimulus, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, response to bacterium, systemic acquired resistance, salicylic acid mediated signaling pathway; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical (InterPro:IPR017178), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type (InterPro:IPR004588); Has 12699 Blast hits to 7350 proteins in 2074 species: Archae - 0; Bacteria - 8133; Metazoa - 2; Fungi - 2; Plants - 72; Viruses - 0; Other Eukaryotes - 4490 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:24359447..24363274 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 82261.30 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 6.39 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.20 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 741 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MATGVLPAPV SGIKIPDSKV GFGKSMNLVR ICDVRSLRSA RRRVSVIRNS NQGSDLAELQ PASEGSPLLV PRQKYCESLH KTVRRKTRTV MVGNVALGSE 101: HPIRIQTMTT SDTKDITGTV DEVMRIADKG ADIVRITVQG KKEADACFEI KDKLVQLNYN IPLVADIHFA PTVALRVAEC FDKIRVNPGN FADRRAQFET 201: IDYTEDEYQK ELQHIEQVFT PLVEKCKKYG RAMRIGTNHG SLSDRIMSYY GDSPRGMVES AFEFARICRK LDYHNFVFSM KASNPVIMVQ AYRLLVAEMY 301: VHGWDYPLHL GVTEAGEGED GRMKSAIGIG TLLQDGLGDT IRVSLTEPPE EEIDPCRRLA NLGTKAAKLQ QGVAPFEEKH RHYFDFQRRT GDLPVQKEGE 401: EVDYRNVLHR DGSVLMSISL DQLKAPELLY RSLATKLVVG MPFKDLATVD SILLRELPPV DDQVARLALK RLIDVSMGVI APLSEQLTKP LPNAMVLVNL 501: KELSGGAYKL LPEGTRLVVS LRGDEPYEEL EILKNIDATM ILHDVPFTED KVSRVHAARR LFEFLSENSV NFPVIHHINF PTGIHRDELV IHAGTYAGGL 601: LVDGLGDGVM LEAPDQDFDF LRNTSFNLLQ GCRMRNTKTE YVSCPSCGRT LFDLQEISAE IREKTSHLPG VSIAIMGCIV NGPGEMADAD FGYVGGSPGK 701: IDLYVGKTVV KRGIAMTEAT DALIGLIKEH GRWVDPPVAD E |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)