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AT5G40820.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:24134884 (2013): cytoskeleton microtubules
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Ataxia telangiectasia-mutated and RAD3-related
Curator
Summary (TAIR10)
Encodes a Arabidopsis ortholog of the ATR protein kinase that is involved in a wide range of responses to DNA damage and plays a central role in cell-cycle regulation. Dominant loss of function alleles identified as suppressors of ALS also exhibit increased tolerance to aluminum. This may be due to the inhibition of terminal differentiation of the root apex upon exposure to Al.
Computational
Description (TAIR10)
Ataxia telangiectasia-mutated and RAD3-related (ATR); FUNCTIONS IN: protein serine/threonine kinase activity, inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: in 9 processes; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), UME (InterPro:IPR012993), Protein kinase-like domain (InterPro:IPR011009), PIK-related kinase, FAT (InterPro:IPR003151), Armadillo-type fold (InterPro:IPR016024), PIK-related kinase (InterPro:IPR014009), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), PIK-related kinase, FATC (InterPro:IPR003152); BEST Arabidopsis thaliana protein match is: ataxia-telangiectasia mutated (TAIR:AT3G48190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G40820-MONOMEREC:2.7.11.1eggNOG:COG5032eggNOG:KOG0890
EMBL:AB011477EMBL:AB040133EMBL:CP002688EnsemblPlants:AT5G40820
EnsemblPlants:AT5G40820.1entrez:834082Gene3D:1.10.1070.11Gene3D:1.25.40.10
GeneID:834082Genevisible:Q9FKS4GO:GO:0004674GO:GO:0005524
GO:GO:0005634GO:GO:0006281GO:GO:0006303GO:GO:0007004
GO:GO:0007126GO:GO:0009506GO:GO:0010044GO:GO:0010332
GO:GO:0016301GO:GO:0032204GO:GO:0032504GO:GO:0033044
GO:GO:0043247Gramene:AT5G40820.1hmmpanther:PTHR11139hmmpanther:PTHR11139:SF69
HOGENOM:HOG000030210InParanoid:Q9FKS4InterPro:IPR000403InterPro:IPR003151
InterPro:IPR003152InterPro:IPR011009InterPro:IPR011990InterPro:IPR012993
InterPro:IPR014009InterPro:IPR016024InterPro:IPR018936iPTMnet:Q9FKS4
KEGG:04150+2.7.11.1KEGG:04151+2.7.11.1KEGG:ath:AT5G40820KO:K06640
OMA:MRGCLKDPaxDb:Q9FKS4Pfam:PF00454Pfam:PF02259
Pfam:PF02260Pfam:PF08064Pfam:Q9FKS4Pfscan:PS50290
Pfscan:PS51189Pfscan:PS51190PhylomeDB:Q9FKS4PRIDE:Q9FKS4
PRO:PR:Q9FKS4PROSITE:PS00916PROSITE:PS50290PROSITE:PS51189
PROSITE:PS51190ProteinModelPortal:Q9FKS4Proteomes:UP000006548Reactome:R-ATH-3371453
RefSeq:NP_198898.2scanprosite:PS00916SMART:SM00146SMART:SM00802
SMART:SM01343SMR:Q9FKS4STRING:3702.AT5G40820.1SUPFAM:SSF48371
SUPFAM:SSF56112TAIR:AT5G40820tair10-symbols:ATATRtair10-symbols:ATR
tair10-symbols:ATRAD3UniGene:At.475UniProt:Q9FKS4
Coordinates (TAIR10) chr5:-:16343860..16353847
Molecular Weight (calculated) 302383.00 Da
IEP (calculated) 7.04
GRAVY (calculated) 0.00
Length 2702 amino acids
Sequence (TAIR10)
(BLAST)
0001: MAKDDNNLSS LVHELRERVA ASASTPANNL RHSSGDEDAL EIRFRAVIPN LLNTYVVPSL GNGREVTAVL KLVGHTARNI PGVFYHGTPS AILPVIARII
0101: PFFAEPEFVP GHGVLLETVG SLLMLLRSNS RKAYRIFFHD ALQAIQDMQP IASLHSIEPE VCESHIPFRC FCMSFSGIGG DLPDANKPRD GDGLVLNLLG
0201: ANRWQPFATC ILKLICKCLT EGTLYVQGLI HTSFFKAACS LVCCGGADVQ MACFEFATLV GSILTFNILP HVALIQSIIL LLSADEGLPV YRNTIYDSTI
0301: GRFLTAVYSS CSDAAVKLTA ESLVLVLSHA LQRTKSEELK ASLCSAYVRI VKSCPPCIWK IHCLLELLHL PEPCFQLIEC FKAVLIVLGP GCVRVETTKC
0401: GSHTSATSDR PVQGINAGKK RHIEDESTYK RKRQKVGDDI RRGVYFAPEF ADETDGKDAA SLREMLISTV ESLKPPPAGP SLSQTESSIV ALSMLTNAFC
0501: FCPWTDMTHR LFNQMYAWIP WIAGQVEETN PIMFDISIYL EGIHNLLLVG VDPQYEYTSK GNDLVAIQFL LKLPWTHYML FKTPSSLVKS KCLSVGIWTK
0601: LGLQDGSDFD IFSWSLSDDF EQVQAVAAIS MPLKVLFSGL GALLHMFPKL EHLLEEKELM IKKAIPQSLG FLSCLYGSST TDSEKTACHL LLHEDLKKDE
0701: TLNSLLQGFR CSKCDKFIER EDEKHFRIIE TPEMVKLKMD HHRDYFNLQS LYFNLLYDES SEETQLACVE VIRRILGHTS PDILVRTRSQ WIRCLQYLLV
0801: HVNTDVREAF CAQIGIFVQH PIVSCLFLSE DATEKSCERN FFNLIEHSLA AAKDLLVIQT LLETTAEVMV AVDVTSELFL ICLFLLIDQL DHPNLIVRIN
0901: ASKLINRSCY IHVKGGFATL LSTASHIQNE LFDNLSVRLT SRPNVVREFA EAVLGVETEE LVRKMVPAVL PKLLVYWQEN AQAANTLNEL AKLIDTDVVP
1001: LIVNWLPRVL AFALNQEEDK NLLSVLQLYH SQIGSDNQEI FAAALPALLD ELVCFVDIAD TPETDRRLQR LPDAIKKISK VLTNAEDLPG FLQNHFVGLL
1101: NSIDRKMLHA DDIFLQKQAL KRIKLLIEMM GHYLSTYVPK LMVLLMHAIE KDALQSEGLL VLHFFTRKLA DVSPSSIKYV ISQIFAALIP FLEKEKEGPH
1201: VYLDEVVKIL EELVLKNRDI VKEHICEFPL LPSIPSLGEL NNAIQEARGL MSLKDQLRDI VNGMKHENLN VRYMVACELS KLLYNRNEDV AALIAGELVS
1301: DMEILSSLIT YLLQGCAEES RTTVGQRLKL VCADCLGAIG AIDPAKVRVA SCSRFKIQCS DDDLIFELIH KHLARAFRAA QDTIIQDSAA LAIQELLKIA
1401: GCEPSLAGNV VVLTPQEHVQ VNVSGSRRCG GNNEVKDRGQ KLWDRFSNYV KELIAPCLTS RFQLPNVSDP GSAGPIYRPS MSFRRWLSYW IRKLTAFATG
1501: SRVSIFAACR GIVRHDMQTA TYLLPYLVLD VVCHGTEAAR LSISEEILSV LDAAASENSG VTINSFGVGQ SEVCVQAVFT LLDNLGQWVD DVKQGVALSS
1601: SLQSSGGRQV APKSKDQVSN STTEQDHLLV QCKYVLELLL AIPKVTLARA SFRCQAYARS LMYLESHVRG KSGSLNPAAE KTGIFENADV SSLMGIYSCL
1701: DEPDGLSGFA SLSKSLNLQD QLLINKKSGN WADVFTACEQ ALQMEPTSVQ RHSDVLNCLL NMCHHQTMVT HVDGLISRVP EYKKTWCTQG VQAAWRLGKW
1801: DLMDEYLDGA DAEGLLFSSS DSNASFDRDV AKILHAMMKK DQYSVAEGIA ISKQALIAPL AAAGMDSYTR AYPFVVKLHL LRELEDFQAV LNGDSYLEKS
1901: FSTSDQVFSK AVDNWENRLR FTQSSLWTRE PLLAFRRLVF GASGLGAQVG NCWLQYAKLC RLAGHYETAH RAILEAQASG APNVHMEKAK LLWITKRSDS
2001: AIIELQQSLL NMPEGVVDST VISSINSLLM APPNPEPTVR NTQSFKEKKD VAKTLLLYSK WIHHSGQKQK KDVLNLYTQV KELLPWEKGY FHLAKYYDEL
2101: YVDARKCQQE SSVFSSAGSK KGSVSSNLST EKAGWDYLFK GMYFYAKALH SGHKNLFQAL PRLLTLWFDF GTIYKTSGSA GNKELKSTHM KIMSLMRGCL
2201: KDLPTYQWLT VLPQLVSRIC HQNADTVLMV KNIITSVLHQ FPQQGLWIMA AVSKSTVPAR REAAAEIIQG ARKGFNQSDR GHNLFIQFAS LTDHFIKLCF
2301: HGGQPRSKVI NIATEFSALK RMMPLDIIMP IQQSLTISLP AFHMNNNERH SASVFSGSDL PTISGIADEA EILSSLQRPK KIILLGNDGI EYPFLCKPKD
2401: DLRKDARMME FTAMINRLLS KYPESRRRKL YIRTFAVAPL TEDCGLVEWV PHTRGLRHIL QDIYISCGKF DRQKTNPQIK RIYDQCAVKK EYEMLKTKIL
2501: PMFPPVFHKW FLTTFSEPAA WFRSRVAYAH TTAVWSMVGH IVGLGDRHGE NILFDSTSGD CVHVDFSCLF DKGLQLEKPE LVPFRLTQNM IDGLGITGYE
2601: GIFMRVCEIT LTVLRTHRET LMSILETFIH DPLVEWTKSH KSSGVEVQNP HAQRAISSIE ARLQGVVVGV PLPVEGQARR LIADAVSLEN LGKMYIWWMP
2701: WF
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)