suba logo
AT5G26780.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

.
SUBAcon:
mitochondrion 1.000
ASURE: mitochondrion
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : serine hydroxymethyltransferase 2
Curator
Summary (TAIR10)
Encodes a protein with serine hydroxymethyltransferase activity which is thought to be localized in the mitochondrial matrix. SHM2 expression fails to rescue the conditional lethal phenotype of the shm1-1 mutant, defective in SHM1.
Computational
Description (TAIR10)
serine hydroxymethyltransferase 2 (SHM2); FUNCTIONS IN: glycine hydroxymethyltransferase activity, cobalt ion binding, zinc ion binding; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: mitochondrion, mitochondrial respiratory chain complex I; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 11653 Blast hits to 11631 proteins in 2851 species: Archae - 258; Bacteria - 6455; Metazoa - 332; Fungi - 287; Plants - 321; Viruses - 6; Other Eukaryotes - 3994 (source: NCBI BLink).
Protein Annotations
EC:2.1.2.1eggNOG:COG0112eggNOG:KOG2467EMBL:AF007270
EMBL:AK318672EMBL:AY035117EMBL:BT001097EMBL:BT001113
EMBL:CP002688EnsemblPlants:AT5G26780EnsemblPlants:AT5G26780.1entrez:832736
Gene3D:3.40.640.10Gene3D:3.90.1150.10GeneID:832736Genevisible:Q94C74
GO:GO:0004372GO:GO:0005739GO:GO:0006544GO:GO:0006563
GO:GO:0030170GO:GO:0035999gramene_pathway:2.1.2.1gramene_pathway:GLYSYN2-PWY
gramene_pathway:PWY-181gramene_pathway:PWY-2161gramene_pathway:PWY-2201gramene_pathway:PWY-3841
HAMAP:MF_00051hmmpanther:PTHR11680hmmpanther:PTHR11680:SF12HOGENOM:HOG000239405
InParanoid:Q94C74InterPro:IPR001085InterPro:IPR015421InterPro:IPR015422
InterPro:IPR015424InterPro:IPR019798KEGG:00260+2.1.2.1KEGG:00460+2.1.2.1
KEGG:00630+2.1.2.1KEGG:00670+2.1.2.1KEGG:00680+2.1.2.1KEGG:ath:AT5G26780
KO:K00600ncoils:CoilOMA:SAYPRHEPANTHER:PTHR11680
PaxDb:Q94C74Pfam:PF00464Pfam:Q94C74PhylomeDB:Q94C74
PIRSF:PIRSF000412PRIDE:Q94C74PRO:PR:Q94C74PROSITE:PS00096
ProteinModelPortal:Q94C74Proteomes:UP000006548Reactome:R-ATH-196757Reactome:R-ATH-71262
RefSeq:NP_568488.2RefSeq:NP_851080.1RefSeq:NP_851081.1scanprosite:PS00096
SMR:Q94C74STRING:3702.AT5G26780.2SUPFAM:SSF53383TAIR:AT5G26780
tair10-symbols:SHM2UniGene:At.22652UniPathway:UPA00193unipathway:UPA00288
UniProt:Q94C74
Coordinates (TAIR10) chr5:+:9418299..9421725
Molecular Weight (calculated) 57345.00 Da
IEP (calculated) 9.11
GRAVY (calculated) -0.29
Length 517 amino acids
Sequence (TAIR10)
(BLAST)
001: MALALRRLSS SVKKPISLLS SNGGSLRFMS SLSTAAMAES EKSRSSWIKQ LNASLDEIDP EVADIIELEK ARQWKGFELI PSENFTSLSV MQAVGSVMTN
101: KYSEGYPGAR YYGGNEYIDM AETLCQKRAL EAFQLDPSKW GVNVQSLSGS PANFQVYTAL LKPHERIMAL DLPHGGHLSH GYQTDTKKIS AVSIFFETMP
201: YRLDENTGYI DYDQLEKSAV LFRPKLIVAG ASAYARLYDY ARIRKVCNKQ KAVMLADMAH ISGLVAAGVI PSPFEYADVV TTTTHKSLRG PRGAMIFFRK
301: GLKEINKQGK EVMYDYEDRI NQAVFPGLQG GPHNHTITGL AVALKQARTP EYKAYQDQVL RNCSKFAETL LAKGYDLVSG GTDNHLVLVN LKNKGIDGSR
401: VEKVLELVHI AANKNTVPGD VSAMVPGGIR MGTPALTSRG FIEEDFAKVA EYFDLAVKIA LKIKAESQGT KLKDFVATMQ SNEKLQSEMS KLREMVEEYA
501: KQFPTIGFEK ETMRYKE
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)