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AT4G36380.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plasma membrane 0.858
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Cytochrome P450 superfamily protein
Curator
Summary (TAIR10)
Encodes a cytochrome P-450 gene that is involved in leaf blade expansion by controlling polar cell expansion in the leaf length direction. Member of the CYP90C CYP450 family. ROT3 was shown to be involved in brassinosteroid biosynthesis, most likely in the conversion step of typhasterol (TY) to castasterone (CS). As 6-deoxo-CS was unable to restore the phenotype of rot3-1, it has been postulated that ROT3 might be specifically involved in the conversion of TY to CS in the C6-oxidation pathway of brassinolide. Recently, CYP90C1 was shown to catalyse the C-23 hydroxylation of several brassinosteroids (the enzyme has a broad specificity for 22-hydroxylated substrates).
Computational
Description (TAIR10)
ROTUNDIFOLIA 3 (ROT3); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 90, subfamily D, polypeptide 1 (TAIR:AT3G13730.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G36380-MONOMERBioCyc:MetaCyc:AT4G36380-MONOMERBRENDA:1.14.13.112EC:1.14.13.112
eggNOG:COG2124eggNOG:KOG0157EMBL:AB008097EMBL:AK228126
EMBL:AL022141EMBL:AL161589EMBL:BT029220EMBL:CP002687
EMBL:Z99708EnsemblPlants:AT4G36380EnsemblPlants:AT4G36380.1entrez:829790
Gene3D:1.10.630.10GeneID:829790Genevisible:Q9M066GO:GO:0005506
GO:GO:0005789GO:GO:0009965GO:GO:0010268GO:GO:0016021
GO:GO:0016125GO:GO:0016132GO:GO:0016709GO:GO:0020037
GO:GO:0042814GO:GO:0048366GO:GO:0048441GO:GO:0048443
Gramene:AT4G36380.1gramene_pathway:1.14.-.-gramene_pathway:1.14.13.-gramene_pathway:1.14.13.112
gramene_pathway:2.7.7.-gramene_pathway:PWY-2582gramene_pathway:PWY-699hmmpanther:PTHR24286
hmmpanther:PTHR24286:SF79HOGENOM:HOG000237614InParanoid:Q9M066InterPro:IPR001128
InterPro:IPR002403InterPro:IPR017972iPTMnet:Q9M066KEGG:ath:AT4G36380
KO:K12637ncoils:CoilOMA:HMDEENYPaxDb:Q9M066
Pfam:PF00067Pfam:Q9M066PhylomeDB:Q9M066PIR:D85429
PIR:T04602PRIDE:Q9M066PRINTS:PR00385PRINTS:PR00465
PRO:PR:Q9M066PROSITE:PS00086ProteinModelPortal:Q9M066Proteomes:UP000006548
Reactome:R-ATH-211916Reactome:R-ATH-5365859RefSeq:NP_568002.1scanprosite:PS00086
SMR:Q9M066STRING:3702.AT4G36380.1SUPFAM:SSF48264TAIR:AT4G36380
tair10-symbols:ROT3TMHMM:TMhelixUniGene:At.19730UniPathway:UPA00381
UniProt:Q9M066
Coordinates (TAIR10) chr4:-:17187973..17192202
Molecular Weight (calculated) 59359.20 Da
IEP (calculated) 7.01
GRAVY (calculated) -0.18
Length 524 amino acids
Sequence (TAIR10)
(BLAST)
001: MQPPASAGLF RSPENLPWPY NYMDYLVAGF LVLTAGILLR PWLWLRLRNS KTKDGDEEED NEEKKKGMIP NGSLGWPVIG ETLNFIACGY SSRPVTFMDK
101: RKSLYGKVFK TNIIGTPIII STDAEVNKVV LQNHGNTFVP AYPKSITELL GENSILSING PHQKRLHTLI GAFLRSPHLK DRITRDIEAS VVLTLASWAQ
201: LPLVHVQDEI KKMTFEILVK VLMSTSPGED MNILKLEFEE FIKGLICIPI KFPGTRLYKS LKAKERLIKM VKKVVEERQV AMTTTSPAND VVDVLLRDGG
301: DSEKQSQPSD FVSGKIVEMM IPGEETMPTA MTLAVKFLSD NPVALAKLVE ENMEMKRRKL ELGEEYKWTD YMSLSFTQNV INETLRMANI INGVWRKALK
401: DVEIKGYLIP KGWCVLASFI SVHMDEDIYD NPYQFDPWRW DRINGSANSS ICFTPFGGGQ RLCPGLELSK LEISIFLHHL VTRYSWTAEE DEIVSFPTVK
501: MKRRLPIRVA TVDDSASPIS LEDH
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)