AT3G25070.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:plasma membrane 1.000 ASURE: plasma membrane What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : RPM1 interacting protein 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation. Major virulence target of the TTSE HopF2Pto. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
RPM1 interacting protein 4 (RIN4); FUNCTIONS IN: protein binding; INVOLVED IN: in 6 processes; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RPM1-interacting protein 4, defence response (InterPro:IPR008700); BEST Arabidopsis thaliana protein match is: defense protein-related (TAIR:AT5G48657.2); Has 373 Blast hits to 371 proteins in 56 species: Archae - 0; Bacteria - 8; Metazoa - 13; Fungi - 2; Plants - 331; Viruses - 0; Other Eukaryotes - 19 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:+:9132458..9133747 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 23372.40 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 9.59 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -1.41 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 211 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MARSNVPKFG NWEAEENVPY TAYFDKARKT RAPGSKIMNP NDPEYNSDSQ SQAPPHPPSS RTKPEQVDTV RRSREHMRSR EESELKQFGD AGGSSNEAAN 101: KRQGRASQNN SYDNKSPLHK NSYDGTGKSR PKPTNLRADE SPEKVTVVPK FGDWDENNPS SADGYTHIFN KVREERSSGA NVSGSSRTPT HQSSRNPNNT 201: SSCCCFGFGG K |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)