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AT3G23780.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : nuclear RNA polymerase D2A
Curator
Summary (TAIR10)
This gene encodes the second largest, catalytic subunit of the nuclear DNA-dependent RNA polymerase IV (aka RNA polymerase D). The NRPD2 protein is found at nuclear foci that overlap or are adjacent to chromocentromeres but are not fully coincident with chromocentromeres. The loss of NRPD2 leads to the loss of cytosine methylation at pericentromeric 5S genes and AtSN1 retroelements but has no discernible effect on centromere repeat methylation. This suggests that Pol IV primarily affects facultative heterochromatin rather than constitutive heterochromatin.
Computational
Description (TAIR10)
nuclear RNA polymerase D2A (NRPD2A); CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, subunit 2, domain 6 (InterPro:IPR007120), RNA polymerase Rpb2, domain 7 (InterPro:IPR007641), RNA polymerase, beta subunit, protrusion (InterPro:IPR007644), RNA polymerase Rpb2, domain 3 (InterPro:IPR007645), DNA-directed RNA polymerase, subunit 2 (InterPro:IPR015712), RNA polymerase Rpb2, domain 2 (InterPro:IPR007642), RNA polymerase Rpb2, domain 4 (InterPro:IPR007646), RNA polymerase, beta subunit, conserved site (InterPro:IPR007121), RNA polymerase Rpb2, domain 5 (InterPro:IPR007647); BEST Arabidopsis thaliana protein match is: nuclear RNA polymerase D2B (TAIR:AT3G18090.1); Has 34269 Blast hits to 26505 proteins in 8656 species: Archae - 497; Bacteria - 15697; Metazoa - 591; Fungi - 7176; Plants - 2585; Viruses - 232; Other Eukaryotes - 7491 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G23780-MONOMERBioCyc:ARA:GQT-1871-MONOMERBioGrid:7292EC:2.7.7.6
eggNOG:COG0085eggNOG:KOG0214EMBL:AK176111EMBL:AP000377
EMBL:AY862891EMBL:AY935711EMBL:CP002686EnsemblPlants:AT3G23780
EnsemblPlants:AT3G23780.1EnsemblPlants:AT3G23780.2entrez:821960Gene3D:2.40.270.10
Gene3D:2.40.50.150Gene3D:3.90.1110.10GeneID:821960Genevisible:Q9LK40
GO:GO:0000418GO:GO:0000419GO:GO:0003677GO:GO:0003899
GO:GO:0005634GO:GO:0005720GO:GO:0005736GO:GO:0006306
GO:GO:0006355GO:GO:0006360GO:GO:0030422GO:GO:0031047
GO:GO:0032549GO:GO:0035194GO:GO:0046872GO:GO:0050776
GO:GO:0050832Gramene:AT3G23780.1Gramene:AT3G23780.2hmmpanther:PTHR20856
hmmpanther:PTHR20856:SF21HOGENOM:HOG000222962InParanoid:Q9LK40InterPro:IPR007120
InterPro:IPR007121InterPro:IPR007641InterPro:IPR007642InterPro:IPR007644
InterPro:IPR007645InterPro:IPR007646InterPro:IPR007647InterPro:IPR014724
InterPro:IPR015712KEGG:00230+2.7.7.6KEGG:00240+2.7.7.6KEGG:ath:AT3G23780
KO:K16252OMA:YSARIIVPANTHER:PTHR20856PaxDb:Q9LK40
Pfam:PF00562Pfam:PF04560Pfam:PF04561Pfam:PF04563
Pfam:PF04565Pfam:PF04566Pfam:PF04567Pfam:Q9LK40
PhylomeDB:Q9LK40PRIDE:Q9LK40PRO:PR:Q9LK40PROSITE:PS01166
ProteinModelPortal:Q9LK40Proteomes:UP000006548RefSeq:NP_001189957.1RefSeq:NP_189020.2
scanprosite:PS01166SMR:Q9LK40STRING:3702.AT3G23780.1SUPFAM:SSF64484
TAIR:AT3G23780tair10-symbols:DMS2tair10-symbols:DRD2tair10-symbols:NRPD2
tair10-symbols:NRPD2Atair10-symbols:NRPE2UniGene:At.37653UniProt:Q9LK40
Coordinates (TAIR10) chr3:-:8567971..8573819
Molecular Weight (calculated) 132661.00 Da
IEP (calculated) 8.42
GRAVY (calculated) -0.38
Length 1172 amino acids
Sequence (TAIR10)
(BLAST)
0001: MPDMDIDVKD LEEFEATTGE INLSELGEGF LQSFCKKAAT SFFDKYGLIS HQLNSYNYFI EHGLQNVFQS FGEMLVEPSF DVVKKKDNDW RYATVKFGEV
0101: TVEKPTFFSD DKELEFLPWH ARLQNMTYSA RIKVNVQVEV FKNTVVKSDK FKTGQDNYVE KKILDVKKQD ILIGSIPVMV KSILCKTSEK GKENCKKGDC
0201: AFDQGGYFVI KGAEKVFIAQ EQMCTKRLWI SNSPWTVSFR SENKRNRFIV RLSENEKAED YKRREKVLTV YFLSTEIPVW LLFFALGVSS DKEAMDLIAF
0301: DGDDASITNS LIASIHVADA VCEAFRCGNN ALTYVEQQIK STKFPPAESV DECLHLYLFP GLQSLKKKAR FLGYMVKCLL NSYAGKRKCE NRDSFRNKRI
0401: ELAGELLERE IRVHLAHARR KMTRAMQKHL SGDGDLKPIE HYLDASVITN GLSRAFSTGA WSHPFRKMER VSGVVANLGR ANPLQTLIDL RRTRQQVLYT
0501: GKVGDARYPH PSHWGRVCFL STPDGENCGL VKNMSLLGLV STQSLESVVE KLFACGMEEL MDDTCTPLFG KHKVLLNGDW VGLCADSESF VAELKSRRRQ
0601: SELPREMEIK RDKDDNEVRI FTDAGRLLRP LLVVENLQKL KQEKPSQYPF DHLLDHGILE LIGIEEEEDC NTAWGIKQLL KEPKIYTHCE LDLSFLLGVS
0701: CAVVPFANHD HGRRVLYQSQ KHCQQAIGFS STNPNIRCDT LSQQLFYPQK PLFKTLASEC LKKEVLFNGQ NAIVAVNVHL GYNQEDSIVM NKASLERGMF
0801: RSEQIRSYKA EVDAKDSEKR KKMDELVQFG KTHSKIGKVD SLEDDGFPFI GANMSTGDIV IGRCTESGAD HSIKLKHTER GIVQKVVLSS NDEGKNFAAV
0901: SLRQVRSPCL GDKFSSMHGQ KGVLGYLEEQ QNFPFTIQGI VPDIVINPHA FPSRQTPGQL LEAALSKGIA CPIQKEGSSA AYTKLTRHAT PFSTPGVTEI
1001: TEQLHRAGFS RWGNERVYNG RSGEMMRSMI FMGPTFYQRL VHMSEDKVKF RNTGPVHPLT RQPVADRKRF GGIKFGEMER DCLIAHGASA NLHERLFTLS
1101: DSSQMHICRK CKTYANVIER TPSSGRKIRG PYCRVCVSSD HVVRVYVPYG AKLLCQELFS MGITLNFDTK LC
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)