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AT2G19900.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : NADP-malic enzyme 1
Curator
Summary (TAIR10)
The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME1 is expressed in response to developmental and cell-specific signals. The enzyme is active in vitro and appears to function as a homohexamer or homooctamer. It is believed to be a cytosolic protein.
Computational
Description (TAIR10)
NADP-malic enzyme 1 (NADP-ME1); FUNCTIONS IN: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity, oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity; INVOLVED IN: malate metabolic process, protein homooligomerization; LOCATED IN: cytosol; EXPRESSED IN: embryo, sperm cell, root, stamen, seed; EXPRESSED DURING: 4 anthesis, D bilateral stage; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 3 (TAIR:AT5G25880.1); Has 9392 Blast hits to 9373 proteins in 2414 species: Archae - 143; Bacteria - 6244; Metazoa - 609; Fungi - 220; Plants - 469; Viruses - 0; Other Eukaryotes - 1707 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G19900-MONOMERBioGrid:1864EC:1.1.1.40eggNOG:COG0281
eggNOG:KOG1257EMBL:AC005169EMBL:AY062734EMBL:BT003371
EMBL:CP002685EnsemblPlants:AT2G19900EnsemblPlants:AT2G19900.1entrez:816509
Gene3D:3.40.50.10380Gene3D:3.40.50.720GeneID:816509Genevisible:O82191
GO:GO:0004471GO:GO:0004473GO:GO:0005829GO:GO:0006108
GO:GO:0008948GO:GO:0046872GO:GO:0051260GO:GO:0051287
Gramene:AT2G19900.1hmmpanther:PTHR23406hmmpanther:PTHR23406:SF26HOGENOM:HOG000042486
InParanoid:O82191IntAct:O82191InterPro:IPR001891InterPro:IPR012301
InterPro:IPR012302InterPro:IPR015884InterPro:IPR016040iPTMnet:O82191
KEGG:ath:AT2G19900KO:K00029OMA:IKEGHIGPaxDb:O82191
Pfam:O82191Pfam:PF00390Pfam:PF03949PhylomeDB:O82191
PIR:E84582PIRSF:PIRSF000106PRIDE:O82191PRINTS:PR00072
PRO:PR:O82191PROSITE:PS00331ProteinModelPortal:O82191Proteomes:UP000006548
RefSeq:NP_179580.1SABIO-RK:O82191scanprosite:PS00331SMART:SM00919
SMART:SM01274SMR:O82191STRING:3702.AT2G19900.1SUPFAM:SSF51735
SUPFAM:SSF53223TAIR:AT2G19900tair10-symbols:ATNADP-ME1tair10-symbols:NADP-ME1
UniGene:At.27251UniProt:O82191
Coordinates (TAIR10) chr2:-:8592106..8595403
Molecular Weight (calculated) 64282.30 Da
IEP (calculated) 6.73
GRAVY (calculated) -0.17
Length 581 amino acids
Sequence (TAIR10)
(BLAST)
001: MEKVTNSDLK SSVDGGVVDV YGEDSATIEH NITPWSLSVS SGYSLLRDPR YNKGLAFTEK ERDTHYLRGL LPPVVLDQKL QEKRLLNNIR QYQFPLQKYM
101: ALTELQERNE RLFYKLLIDN VEELLPIVYT PTVGEACQKF GSIFRRPQGL FISLKDKGKI LDVLKNWPER NIQVIVVTDG ERILGLGDLG CQGMGIPVGK
201: LALYSALGGV RPSACLPVTI DVGTNNEKLL NDEFYIGLRQ KRATGQEYSE LLNEFMSAVK QNYGEKVLIQ FEDFANHNAF ELLAKYSDTH LVFNDDIQGT
301: ASVVLAGLVS AQKLTNSPLA EHTFLFLGAG EAGTGIAELI ALYMSKQMNA SVEESRKKIW LVDSKGLIVN SRKDSLQDFK KPWAHEHEPV KDLLGAIKAI
401: KPTVLIGSSG VGRSFTKEVI EAMSSINERP LIMALSNPTT QSECTAEEAY TWSKGRAIFA SGSPFDPVEY EGKVFVSTQA NNAYIFPGFG LGLVISGAIR
501: VHDDMLLAAA EALAGQVSKE NYEKGMIYPS FSSIRKISAQ IAANVATKAY ELGLAGRLPR PKDIVKCAES SMYSPTYRLY R
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)