suba logo
AT1G28380.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

.
SUBAcon:
plasma membrane 0.932
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : MAC/Perforin domain-containing protein
Curator
Summary (TAIR10)
This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.
Computational
Description (TAIR10)
necrotic spotted lesions 1 (NSL1); CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain (InterPro:IPR020864); BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein (TAIR:AT4G24290.2); Has 203 Blast hits to 202 proteins in 18 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 202; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
Protein Annotations
eggNOG:ENOG410IJ0ZeggNOG:ENOG410ZJIWEMBL:AC010155EMBL:AY059744
EMBL:AY096632EMBL:CP002684EnsemblPlants:AT1G28380EnsemblPlants:AT1G28380.1
entrez:839735GeneID:839735Genevisible:Q9SGN6GO:GO:0006955
GO:GO:0008219GO:GO:0009626GO:GO:0009651GO:GO:0010337
GO:GO:0052542Gramene:AT1G28380.1hmmpanther:PTHR33199hmmpanther:PTHR33199:SF8
HOGENOM:HOG000238669InParanoid:Q9SGN6InterPro:IPR020864iPTMnet:Q9SGN6
KEGG:ath:AT1G28380OMA:GQSHERWPaxDb:Q9SGN6Pfam:PF01823
Pfam:Q9SGN6Pfscan:PS51412PhylomeDB:Q9SGN6PIR:C86410
PRIDE:Q9SGN6PRO:PR:Q9SGN6PROSITE:PS51412ProteinModelPortal:Q9SGN6
Proteomes:UP000006548RefSeq:NP_564307.1SMART:SM00457STRING:3702.AT1G28380.1
TAIR:AT1G28380tair10-symbols:NSL1TCDB:1.C.39.11.4UniGene:At.22050
UniGene:At.75589UniProt:Q9SGN6
Coordinates (TAIR10) chr1:+:9963696..9966060
Molecular Weight (calculated) 67983.80 Da
IEP (calculated) 9.13
GRAVY (calculated) -0.25
Length 612 amino acids
Sequence (TAIR10)
(BLAST)
001: MAFNNFTRLD AHSAAEKAVS VIGLGYDLCS DVRFSACKTT PDGSRLVEID PTRNRDLIFP GGIVVNNVSS SIKCDKGERT RLRSDILSFN QMSEKFNQDM
101: CLSGKIPSGM FNNMFAFSKC WPKDASSVKT LAYDGWFISL YSVEIVRKQL TLRDEVKREV PSSWDSAALA GFIEKYGTHV VVGVTMGGKD VIHVKQMRKS
201: NHEPEEIQKM LKHWGDERFC VDPVESKSPA SVYSGKPKEE NLLQWGLQPF GTSVSSAVVM HTKNEEIMRV CIRRGGVDLG QSHERWLSTV SQAPNVISMC
301: FVPITSLLSG LPGTGFLSHA VNLYLRYKPP IEELHQFLEF QLPRQWAPVY GDLPLGLRRS KQSSPSLQFS LMGPKLYVNT SKVDSGERPV TGLRFFLEGK
401: KGNHLAIHLQ HLSACPPSLH LSHDDTYEPI EEPVEKGYYV PVKWGIFSHV CTYPVQYNGA RSDDTASIVT KAWLEVKGMG MRKVLFLRLG FSLDASAVTR
501: KSCWDNLSTN SRKSGVFSMI STRLSTGLSP NPATTKPQSK IDINSAVYPR GPSPPVKPKL LSLVDTKEVM RGPEEQPGYW VVTGAKLCVE AGKISIKAKY
601: SLLTVISEDS LV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)