AT3G13300.2
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:cytosol 1.000 ASURE: cytosol What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : Transducin/WD40 repeat-like superfamily protein | ||||||||||||
| Curator Summary (TAIR10) |
Encodes VCS (VARICOSE). Involved in mRNA decapping. VCS forms a mRNA decapping complex with DCP1 (At1g08370) and DCP2 (At5g13570). Unlike DCP2, VCS itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. VCS is also required for leaf development. | ||||||||||||
| Computational Description (TAIR10) |
VARICOSE (VCS); FUNCTIONS IN: protein homodimerization activity, nucleotide binding; INVOLVED IN: mRNA catabolic process, deadenylation-independent decapping of nuclear-transcribed mRNA, leaf morphogenesis; LOCATED IN: cytosol, nucleus, cytoplasmic mRNA processing body; EXPRESSED IN: whole plant, guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat 2 (InterPro:IPR019782), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: varicose-related (TAIR:AT3G13290.1); Has 885 Blast hits to 799 proteins in 264 species: Archae - 2; Bacteria - 218; Metazoa - 230; Fungi - 185; Plants - 114; Viruses - 4; Other Eukaryotes - 132 (source: NCBI BLink). | ||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:+:4304085..4309949 | ||||||||||||
| Molecular Weight (calculated) | 142042.00 Da | ||||||||||||
| IEP (calculated) | 5.96 | ||||||||||||
| GRAVY (calculated) | -0.35 | ||||||||||||
| Length | 1309 amino acids | ||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MASSPGPFLH NQYDQQHYAP PGISAQPSPV TQQQQDVSSS SAATNLHPQR TLSYPTPPLN LQSPRSNHNP GTHILALLNN TNNGAPVANQ EPSHQLPVVN 0101: HNEIARSFPG GSGPIRVPSC KLPKGRRLIG EHAVYDVDVR LQGEIQPQLE VTPITKYGSD PQLVVGRQIA VNKVYICYGL KGGNIRVLNI NTALRSLFRG 0201: HSQRVTDMAF FAEDVDMLAS VSLDGKVFVW KISEGSEGED QPQITGKIVL ALQILGEEDT KHPRVCWHCH KQEILVVSIG KHVLRIDTTK VGRGEVFSAE 0301: APLQCPLDKL IDGVQIVGKH DGEVTDLSMC QWMTTRLVSS SVDGTIKIWQ DRKAQPLVVL RPHDGHPVSS ATFVTSPERP DHIILITGGP LNREMKIWVS 0401: AGEEGWLLPA DAESWRCTQT LDLKSSTEPR AEEAFFNQVI ALSEAGLLLL ANAKRNALYA VHLDYGSSPV GTRMDYLSEF TVTMPILSFI GTNDPPEEPI 0501: VKVYCVQTLA IQQYTLDLCL CLPPPIENMG LEKSDSSVSR EANLVEGMSE PSGLKPTDLP SVDSVPKPSI IVNRSESANK LSFPSAEATS QAIVPPNGEP 0601: KTSGLPSQTS GAGSAYATLP QLPLSPRLSS KLSGYHTPVE AIEPVIPHHE LGGKTPSADY SVDRQMDAVG ERNLDVSSVE EISRSKDSNV TPDDDVSGMR 0701: SPSAFFKHPT HLVTPSEILM GVSSAEASIT TEDRRDRDAN IQDVNNDPRD TEVEVKEISE ARSTQNGEIN DHDETENCTS ENREKVFCSQ VSNLSTEMAR 0801: DCYPSTEGTF IPGESKAYGQ PIKAGDESGV DSRGGPAKLL KGKKQKAKNS QGPGLSSTSS NVANLADSFN EQSQSLSHPM TDLLPQLLAM QETMNQVMAS 0901: QKEMQRQLSN AATGPIGKES KRLEVALGRM IEKSSKSNAD ALWARIQEET VKNEKALRDH AQQIVNATTN FMSKELNAMF EKTIKKELAA IGPALARSVV 1001: PVIEKTVSSA ITESFQRGIG DKAVNQLDKS VNIKLEATVA RQIQAQFQTS GKQALQEGLR SSVESSVIPS FEKACKAMFD QIDSAFQKGI AEHTNAAQQR 1101: FDSGHSQLAH TLKESITSAS SVAQALSREL AETQRNLLAL AAAGANSGGS NSLVTQLSGG PLGALLEKVE APMDPTTELS RLISERKYEE SFTSALQRSD 1201: VSIVSWLCSQ VDLRGLLAMN PLPLSQGVLL SLLQQLACDI SKDTSRKLAW MTDVVAAINP SDQMIAVHAR PIFEQVYQIL HHHRNAPGSD VSAIRLIMHV 1301: INSMLMGCK |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)