AT1G50240.2
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:cytosol 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : Protein kinase family protein with ARM repeat domain | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
FUSED (FU); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), 26S proteasome non-ATPase regulatory subunit 5 (InterPro:IPR019538), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 138334 Blast hits to 135590 proteins in 4834 species: Archae - 164; Bacteria - 15793; Metazoa - 51363; Fungi - 13983; Plants - 33508; Viruses - 544; Other Eukaryotes - 22979 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr1:+:18607063..18614094 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 145422.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.44 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.03 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 1322 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MGVEDYHVIE LVGEGSFGRV YKGRRKYTGQ TVAMKFIMKQ GKTDKDIHSL RQEIEILRKL KHENIIEMLD SFENAREFCV VTEFAQGELF EILEDDKCLP 0101: EEQVQAIAKQ LVKALDYLHS NRIIHRDMKP QNILIGAGSV VKLCDFGFAR AMSTNTVVLR SIKGTPLYMA PELVKEQPYD RTVDLWSLGV ILYELYVGQP 0201: PFYTNSVYAL IRHIVKDPVK YPDEMSTYFE SFLKGLLNKE PHSRLTWPAL REHPFVKETQ EEVEAREIHT AVVDNKAAWM LKGNGGQQRN EKCDSVTLVE 0301: DMSATKGLAD VQSDMKSAVK VNSPPTEDFV GFPTQEEIKS SGNPTLDKLE NTSRTVKGAQ VIGENDKALD LVLLSLERFS KSPDSKRDKD VACSVQSLRI 0401: ISNLVATRAI VSVGLIEKIT CALLDFTDAL VGMKSPEFNN IIPKSLSVTK NLVGHVEGNN IHSSYIRHWT KVVEIFIQVV RWEEEGTGRI IYEACSCITT 0501: MLSRVAQDLK SSTPDSVSKQ ILEHANMSRI VDHLCLCLAS SGSSLTSGSS QMLAAACEAC RAIWILIDTS ETFFKNDDVN ILPLDALQNR LSQHDIGNSE 0601: WGPLSEKLVD TVTRAYLRSK HVQVAVGHCL HQRVEAPLVS AIQLLSRCCL HNGILPSMLC GLPSSLPITT VVSGGEDGTV ISEIFSILSY ATLSSKDQQT 0701: GEKDNFEGRL NNLVFHSCLM LATVAQCLKL TGRNSVLLML TTSPKKHQHR LSAIANHIAS DDKIEASLQN HSASAMLALA SILALEKGSS AGSSVSELVV 0801: SLIPRATKLC YHLRPMPSNE GEVISHSANY AKWHGLLDGC IGLLESRLKW GGPLAVQQLI ASGTPLLLIN LLAGKLSNAS PEDIKKTSNR IGLSPIGVVW 0901: TISSICHCLS GGTTFRQVLV KIETMKLITC LLSDAHIKLV KSWGGPGGGK DGVRETINVI IDLLAFPFVA LQSQPGSLSA TASVNSGFIL NIGSPGVRVC 1001: MEDRDLLKAI EEDMDKYIIV LLEVGVPSLI LRCLDHLELK DLVRPVAFLA KMVGRPRLAV DLVSKGLLDP NRMKKLLNQS SPREVILDIL MIISDLSRMD 1101: KAFYKYIGEA SVLQPLKEYL THVDPNIRAK ACSALGNMCR HNGYFYSALA EHQIIGLLID RCADPDKRTQ KFACFAIGNA AYHNDTLYEE LRRSITQLAN 1201: VLTTAEEDKT KANAAGALSN LVRNSNKLCE DIVSKGALQT LLRLVADCST LALNPSKKET ASESPLKIAL FSLAKMCSNH QICRQFVKSS ELFPVIARLK 1301: QSPEANIAHY ASVIVAKVSG ES |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)