suba logo
AT2G36490.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

.
SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28865150 (2017): extracellular region plant-type cell wall
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : demeter-like 1
Curator
Summary (TAIR10)
A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts.
Computational
Description (TAIR10)
demeter-like 1 (DML1); FUNCTIONS IN: protein binding, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity; INVOLVED IN: DNA repair, chromatin silencing, negative regulation of chromatin silencing, DNA methylation, DNA demethylation; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: HhH-GPD base excision DNA repair family protein (TAIR:AT5G04560.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
Protein Annotations
BioGrid:3568EC:3.2.2.-eggNOG:COG0177eggNOG:ENOG410IFAB
EMBL:AC006919EMBL:AY286009EMBL:CP002685EnsemblPlants:AT2G36490
EnsemblPlants:AT2G36490.1entrez:818224Gene3D:1.10.1670.10Gene3D:1.10.340.30
GeneID:818224Genevisible:Q9SJQ6GO:GO:0003677GO:GO:0003906
GO:GO:0005634GO:GO:0005730GO:GO:0006281GO:GO:0006284
GO:GO:0006306GO:GO:0006342GO:GO:0006351GO:GO:0019104
GO:GO:0031936GO:GO:0046872GO:GO:0051539GO:GO:0080111
Gramene:AT2G36490.1hmmpanther:PTHR10359hmmpanther:PTHR10359:SF22HOGENOM:HOG000154178
InParanoid:Q9SJQ6InterPro:IPR003265InterPro:IPR003651InterPro:IPR011257
InterPro:IPR023170InterPro:IPR028924InterPro:IPR028925KEGG:ath:AT2G36490
MINT:MINT-8064366OMA:GHARFRNPaxDb:Q9SJQ6Pfam:PF15628
Pfam:PF15629Pfam:Q9SJQ6PhylomeDB:Q9SJQ6PIR:D84781
PRIDE:Q9SJQ6PRO:PR:Q9SJQ6ProteinModelPortal:Q9SJQ6Proteomes:UP000006548
RefSeq:NP_181190.3SMART:SM00478SMART:SM00525SMR:Q9SJQ6
STRING:3702.AT2G36490.1SUPFAM:SSF48150TAIR:AT2G36490tair10-symbols:DML1
tair10-symbols:ROS1UniGene:At.14091UniProt:Q9SJQ6
Coordinates (TAIR10) chr2:-:15308259..15314272
Molecular Weight (calculated) 156556.00 Da
IEP (calculated) 7.38
GRAVY (calculated) -0.66
Length 1393 amino acids
Sequence (TAIR10)
(BLAST)
0001: MEKQRREESS FQQPPWIPQT PMKPFSPICP YTVEDQYHSS QLEERRFVGN KDMSGLDHLS FGDLLALANT ASLIFSGQTP IPTRNTEVMQ KGTEEVESLS
0101: SVSNNVAEQI LKTPEKPKRK KHRPKVRREA KPKREPKPRA PRKSVVTDGQ ESKTPKRKYV RKKVEVSKDQ DATPVESSAA VETSTRPKRL CRRVLDFEAE
0201: NGENQTNGDI REAGEMESAL QEKQLDSGNQ ELKDCLLSAP STPKRKRSQG KRKGVQPKKN GSNLEEVDIS MAQAAKRRQG PTCCDMNLSG IQYDEQCDYQ
0301: KMHWLYSPNL QQGGMRYDAI CSKVFSGQQH NYVSAFHATC YSSTSQLSAN RVLTVEERRE GIFQGRQESE LNVLSDKIDT PIKKKTTGHA RFRNLSSMNK
0401: LVEVPEHLTS GYCSKPQQNN KILVDTRVTV SKKKPTKSEK SQTKQKNLLP NLCRFPPSFT GLSPDELWKR RNSIETISEL LRLLDINREH SETALVPYTM
0501: NSQIVLFGGG AGAIVPVTPV KKPRPRPKVD LDDETDRVWK LLLENINSEG VDGSDEQKAK WWEEERNVFR GRADSFIARM HLVQGDRRFT PWKGSVVDSV
0601: VGVFLTQNVS DHLSSSAFMS LASQFPVPFV PSSNFDAGTS SMPSIQITYL DSEETMSSPP DHNHSSVTLK NTQPDEEKDY VPSNETSRSS SEIAISAHES
0701: VDKTTDSKEY VDSDRKGSSV EVDKTDEKCR VLNLFPSEDS ALTCQHSMVS DAPQNTERAG SSSEIDLEGE YRTSFMKLLQ GVQVSLEDSN QVSPNMSPGD
0801: CSSEIKGFQS MKEPTKSSVD SSEPGCCSQQ DGDVLSCQKP TLKEKGKKVL KEEKKAFDWD CLRREAQARA GIREKTRSTM DTVDWKAIRA ADVKEVAETI
0901: KSRGMNHKLA ERIQGFLDRL VNDHGSIDLE WLRDVPPDKA KEYLLSFNGL GLKSVECVRL LTLHHLAFPV DTNVGRIAVR LGWVPLQPLP ESLQLHLLEM
1001: YPMLESIQKY LWPRLCKLDQ KTLYELHYQM ITFGKVFCTK SKPNCNACPM KGECRHFASA FASARLALPS TEKGMGTPDK NPLPLHLPEP FQREQGSEVV
1101: QHSEPAKKVT CCEPIIEEPA SPEPETAEVS IADIEEAFFE DPEEIPTIRL NMDAFTSNLK KIMEHNKELQ DGNMSSALVA LTAETASLPM PKLKNISQLR
1201: TEHRVYELPD EHPLLAQLEK REPDDPCSYL LAIWTPGETA DSIQPSVSTC IFQANGMLCD EETCFSCNSI KETRSQIVRG TILIPCRTAM RGSFPLNGTY
1301: FQVNEVFADH ASSLNPINVP RELIWELPRR TVYFGTSVPT IFKGLSTEKI QACFWKGYVC VRGFDRKTRG PKPLIARLHF PASKLKGQQA NLA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)