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AT2G30110.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31818904 (2020): mitochondrion
  • PMID:31520498 (2020): mitochondrion
  • PMID:31186290 (2019): cytosol None
  • PMID:30783145 (2019): extracellular region plant-type cell wall
  • PMID:30447334 (2019): plasma membrane
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:27137770 (2016): plastid plastid stroma
  • PMID:27122571 (2016): mitochondrion
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:23673981 (2013): plastid plastid stroma plastoglobules
  • PMID:22215637 (2012): plasma membrane
  • PMID:21433285 (2011): plasma membrane
  • PMID:21166475 (2011): cytosol
  • PMID:19334764 (2009): plasma membrane
  • PMID:17317660 (2007): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : ubiquitin-activating enzyme 1
Curator
Summary (TAIR10)
Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined. Mutant is able to revert the constitutive defense responses phenotype of snc1, which indicates the gene is involved in defense response. It also indicates that ubiquitination plays a role in plant defense signalling.
Computational
Description (TAIR10)
ubiquitin-activating enzyme 1 (UBA1); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: response to cadmium ion, response to other organism, protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), Ubiquitin-activating enzyme e1, C-terminal (InterPro:IPR018965), Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ubiquitin activating enzyme 2 (TAIR:AT5G06460.1); Has 19490 Blast hits to 12603 proteins in 2346 species: Archae - 393; Bacteria - 11015; Metazoa - 2131; Fungi - 1366; Plants - 791; Viruses - 0; Other Eukaryotes - 3794 (source: NCBI BLink).
Protein Annotations
BioGrid:2911BRENDA:6.2.1.B9EC:6.2.1.45eggNOG:COG0476
eggNOG:KOG2012EMBL:AC004165EMBL:AY090248EMBL:BT006363
EMBL:CP002685EMBL:U80808EnsemblPlants:AT2G30110EnsemblPlants:AT2G30110.1
entrez:817562Gene3D:1.10.3240.10Gene3D:3.40.50.720GeneID:817562
Genevisible:P93028GO:GO:0004842GO:GO:0005524GO:GO:0005634
GO:GO:0005829GO:GO:0005886GO:GO:0008641GO:GO:0009506
GO:GO:0016567GO:GO:0046686GO:GO:0051707Gramene:AT2G30110.1
hmmpanther:PTHR10953hmmpanther:PTHR10953:SF164HOGENOM:HOG000167329InParanoid:P93028
IntAct:P93028InterPro:IPR000011InterPro:IPR000594InterPro:IPR016040
InterPro:IPR018074InterPro:IPR018075InterPro:IPR018965InterPro:IPR019572
InterPro:IPR032418InterPro:IPR032420InterPro:IPR033127iPTMnet:P93028
KEGG:ath:AT2G30110KO:K03178OMA:PPGFRMKPaxDb:P93028
Pfam:P93028Pfam:PF00899Pfam:PF09358Pfam:PF10585
Pfam:PF16190Pfam:PF16191PhylomeDB:P93028PIR:T00587
PRIDE:P93028PRINTS:PR01849PRO:PR:P93028PROSITE:PS00536
PROSITE:PS00865ProteinModelPortal:P93028Proteomes:UP000006548Reactome:R-ATH-1169408
RefSeq:NP_565693.1scanprosite:PS00536scanprosite:PS00865SMART:SM00985
SMR:P93028STRING:3702.AT2G30110.1SUPFAM:SSF69572TAIR:AT2G30110
tair10-symbols:ATUBA1tair10-symbols:MOS5tair10-symbols:UBA1TIGRfam:TIGR01408
TIGRFAMs:TIGR01408UniGene:At.21347UniPathway:UPA00143UniProt:P93028
Coordinates (TAIR10) chr2:-:12852632..12857369
Molecular Weight (calculated) 120257.00 Da
IEP (calculated) 4.90
GRAVY (calculated) -0.26
Length 1080 amino acids
Sequence (TAIR10)
(BLAST)
0001: MLHKRASEAN DKNDNTIIGS DLASSKKRRI DFTESSSDKS SSILASGSSR GFHGDSVVQQ IDMAFGNSNR QEIDEDLHSR QLAVYGRETM RRLFASNVLI
0101: SGMHGLGAEI AKNLILAGVK SVTLHDERVV ELWDLSSNFV FSEDDVGKNR ADASVQKLQD LNNAVVVSSL TKSLNKEDLS GFQVVVFSDI SMERAIEFDD
0201: YCHSHQPPIA FVKADVRGLF GSVFCDFGPE FAVLDVDGEE PHTGIIASIS NENQAFISCV DDERLEFEDG DLVVFSEVEG MTELNDGKPR KIKSTRPYSF
0301: TLDEDTTNYG TYVKGGIVTQ VKQPKLLNFK PLREALKDPG DFLFSDFSKF DRPPLLHLAF QALDHFKAEA GRFPVAGSEE DAQKLISIAT AINTGQGDLK
0401: VENVDQKLLR HFSFGAKAVL NPMAAMFGGI VGQEVVKACS GKFHPLFQFF YFDSVESLPS EPVDSSDFAP RNSRYDAQIS VFGAKFQKKL EDAKVFTVGS
0501: GALGCEFLKN LALMGVSCGS QGKLTVTDDD IIEKSNLSRQ FLFRDWNIGQ AKSTVAASAA AVINPRFNIE ALQNRVGAET ENVFDDAFWE NLTVVVNALD
0601: NVNARLYVDS RCLYFQKPLL ESGTLGTKCN TQSVIPHLTE NYGASRDPPE KQAPMCTVHS FPHNIDHCLT WARSEFEGLL EKTPAEVNAY LSSPVEYTNS
0701: MMSAGDAQAR DTLERIVECL EKEKCETFQD CLTWARLRFE DYFVNRVKQL IYTFPEDAAT STGAPFWSAP KRFPRPLQYS SSDPSLLNFI TATAILRAET
0801: FGIPIPEWTK NPKEAAEAVD RVIVPDFEPR QDAKIVTDEK ATTLTTASVD DAAVIDDLIA KIDQCRHNLS PDFRMKPIQF EKDDDTNYHM DVIAGLANMR
0901: ARNYSIPEVD KLKAKFIAGR IIPAIATSTA MATGLVCLEL YKVLDGGHKV EAYRNTFANL ALPLFSMAEP LPPKVVKHRD MAWTVWDRWV LKGNPTLREV
1001: LQWLEDKGLS AYSISCGSCL LFNSMFTRHK ERMDKKVVDL ARDVAKVELP PYRNHLDVVV ACEDEDDNDV DIPLVSIYFR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)