AT1G72970.1
|
Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:extracellular 0.999 What is SUBAcon? |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Localisations and PPI |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
SUBAcon links
AGI-AGI relationships |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description (TAIR10) | protein_coding : Glucose-methanol-choline (GMC) oxidoreductase family protein | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Originally identified as a mutation that causes floral organs to fuse together. About 10-20% of mutants also have defects in ovules. Mutants have reduced fertility most likely as because of fusions that pistil emergence. The protein has similarity to the mandelonitrile lyase family of FAD containing oxidoreductases and is predicted to be secreted (SignalP).It is expressed in all tissue layers of roots, inflorescences, stems, leaves, and flowers and is also expressed in siliques. Expression is highest in inflorescence and flower tissue.Transmission of mutant alleles to the progeny shows non mendelian segregation- a percentage of mutant alleles revert back to a previous parental (e.g. grandparental) wild type allele. It has been suggested that an RNA template driven or other extra-DNA genomic mechanism may be responsible for the non-mendelian inheritance of HTH. Reversion events in alleles at other loci have also been observed to occur in plants with an hth mutant background indicating a genome wide effect. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
HOTHEAD (HTH); CONTAINS InterPro DOMAIN/s: Glucose-methanol-choline oxidoreductase, N-terminal (InterPro:IPR000172), Glucose-methanol-choline oxidoreductase (InterPro:IPR012132), Glucose-methanol-choline oxidoreductase, C-terminal (InterPro:IPR007867); BEST Arabidopsis thaliana protein match is: Glucose-methanol-choline (GMC) oxidoreductase family protein (TAIR:AT1G12570.1); Has 10392 Blast hits to 10274 proteins in 1087 species: Archae - 4; Bacteria - 3747; Metazoa - 796; Fungi - 1463; Plants - 312; Viruses - 12; Other Eukaryotes - 4058 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Coordinates (TAIR10) | chr1:+:27452872..27455706 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 65347.80 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 10.25 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.19 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 594 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MALKLFLFAL LLCLPTSLSS TASKGKEKKS KFNPYRYTFI DKASTFSSSS SSSFSSNGQD SSYDYIVIGG GTAGCPLAAT LSQNFSVLVL ERGGVPFTNA 101: NVSFLRNFHI GLADISASSA SQAFVSTDGV YNARARVLGG GSCINAGFYS RADAAFVKRA GWDPKLVKES YPWVEREIVH QPKLTLWQKA LRDSLLEVGV 201: RPFNGFTYDH VSGTKIGGTI FDRFGRRHTA AELLAYANPQ KLRVLIYATV QKIVFDTSGT RPRVTGVIFK DEKGNQHQAL LSNRKGSEVI LSSGAIGSPQ 301: MLMLSGIGPK KELQRLKIPV VLENEHVGKG MADNPMNTIL VPSKAPIEQS LIQTVGITKM GVYVEASTGF GQSPESIHTH YGIMSNKNEL FSTIPAKQRR 401: PEATQAYITR NKYQLHEAFN GSFILEKLAY PISRGHLSLV NTNVDDNPSV TFNYFKHPVD LQRCVEAIRL VSKVVTSNRF LNYTQCDKQN VHKMLSLSVK 501: ANINLRPKQL NDTKSMAQFC KDTVVTIWHY HGGCLVGKVV SPNRKVLGVD RLRVIDGSTF DESPGTNPQA TMMMMGRYMG VKILRERLGN KAGV |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| See Also |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)