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AT5G36880.2
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plastid 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31520498 (2020): mitochondrion
  • PMID:28865150 (2017): extracellular region plant-type cell wall
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : acetyl-CoA synthetase
Curator
Summary (TAIR10)
Encodes a plastidic acetyl-coA synthetase. This enzyme plays a role in converting acetate to acetyl-coA in the plastids. It does not appear to be a major contributor to fatty acid biosynthesis based on mutant phenotypes. The enzyme seems to act as a monomer and may play an important role in preventing the toxic accumulation of fermentation products including acetaldehyde, acetate, and ethanol. It participates in the pyruvate dehydrogenase bypass pathway
Computational
Description (TAIR10)
acetyl-CoA synthetase (ACS); FUNCTIONS IN: acetate-CoA ligase activity; INVOLVED IN: metabolic process, acetate metabolic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acetate--CoA ligase (InterPro:IPR011904), AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: acyl-activating enzyme 17 (TAIR:AT5G23050.1); Has 68981 Blast hits to 63577 proteins in 3326 species: Archae - 1100; Bacteria - 43606; Metazoa - 2469; Fungi - 2489; Plants - 1499; Viruses - 1; Other Eukaryotes - 17817 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G36880-MONOMERBioGrid:18906BRENDA:6.2.1.1EC:6.2.1.1
eggNOG:COG0365eggNOG:KOG1175EMBL:AB025605EMBL:AF036618
EMBL:AK317115EMBL:AY045880EMBL:BT002371EMBL:CP002688
EnsemblPlants:AT5G36880EnsemblPlants:AT5G36880.2entrez:833655GeneID:833655
Genevisible:B9DGD6GO:GO:0003987GO:GO:0005524GO:GO:0005829
GO:GO:0006083GO:GO:0006631GO:GO:0009507GO:GO:0009514
GO:GO:0009570GO:GO:0016208GO:GO:0019427gramene_pathway:6.2.1.1
gramene_pathway:PWY66-162gramene_pathway:PWY66-21hmmpanther:PTHR24095hmmpanther:PTHR24095:SF178
HOGENOM:HOG000229981InParanoid:B9DGD6InterPro:IPR000873InterPro:IPR011904
InterPro:IPR020845InterPro:IPR025110InterPro:IPR032387iPTMnet:B9DGD6
KEGG:00010+6.2.1.1KEGG:00620+6.2.1.1KEGG:00640+6.2.1.1KEGG:00680+6.2.1.1
KEGG:00720+6.2.1.1KEGG:ath:AT5G36880KO:K01895OMA:AISKHEM
PaxDb:B9DGD6Pfam:B9DGD6Pfam:PF00501Pfam:PF13193
Pfam:PF16177PhylomeDB:B9DGD6PRIDE:B9DGD6PRO:PR:B9DGD6
PROSITE:PS00455ProteinModelPortal:B9DGD6Proteomes:UP000006548Reactome:R-ATH-71384
RefSeq:NP_001031974.2RefSeq:NP_198504.1scanprosite:PS00455SMR:B9DGD6
STRING:3702.AT5G36880.2SUPFAM:SSF56801TAIR:AT5G36880tair10-symbols:ACS
TIGRfam:TIGR02188TIGRFAMs:TIGR02188UniGene:At.21024UniProt:B9DGD6
Coordinates (TAIR10) chr5:-:14534961..14540296
Molecular Weight (calculated) 81893.40 Da
IEP (calculated) 5.95
GRAVY (calculated) -0.17
Length 743 amino acids
Sequence (TAIR10)
(BLAST)
001: MKIGSPSSPI LSVVSSSGSL DPKISGSLGS RILPATQRSS PSENLLLHRK MSSNSLRHVE SMSQLPSGAG KISQLNAVVL GESLASEEND LVFPSKEFSG
101: QALVSSPQQY MEMHKRSMDD PAAFWSDIAS EFYWKQKWGD QVFSENLDVR KGPISIEWFK GGITNICYNC LDKNVEAGLG DKTAIHWEGN ELGVDASLTY
201: SELLQRVCQL ANYLKDNGVK KGDAVVIYLP MLMELPIAML ACARIGAVHS VVFAGFSADS LAQRIVDCKP NVILTCNAVK RGPKTINLKA IVDAALDQSS
301: KDGVSVGICL TYDNSLATTR ENTKWQNGRD VWWQDVISQY PTSCEVEWVD AEDPLFLLYT SGSTGKPKGV LHTTGGYMIY TATTFKYAFD YKSTDVYWCT
401: ADCGWITGHS YVTYGPMLNG ATVVVFEGAP NYPDPGRCWD IVDKYKVSIF YTAPTLVRSL MRDDDKFVTR HSRKSLRVLG SVGEPINPSA WRWFFNVVGD
501: SRCPISDTWW QTETGGFMIT PLPGAWPQKP GSATFPFFGV QPVIVDEKGN EIEGECSGYL CVKGSWPGAF RTLFGDHERY ETTYFKPFAG YYFSGDGCSR
601: DKDGYYWLTG RVDDVINVSG HRIGTAEVES ALVLHPQCAE AAVVGIEHEV KGQGIYAFVT LLEGVPYSEE LRKSLVLMVR NQIGAFAAPD RIHWAPGLPK
701: TRSGKIMRRI LRKIASRQLE ELGDTSTLAD PSVVDQLIAL ADV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)