AT4G26970.1
Subcellular Consensus
(Prediction and Experimental) min: :max .
SUBAcon:mitochondrion 1.000 ASURE: mitochondrion What is SUBAcon? |
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Experimental Localisations and PPI |
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FP Images |
Arabidopsis cell culture (mitochondrial marker)
Arabidopsis cell culture (plastidal marker)
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SUBAcon links
AGI-AGI relationships |
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Description (TAIR10) | protein_coding : aconitase 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Curator Summary (TAIR10) |
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Computational Description (TAIR10) |
aconitase 2 (ACO2); FUNCTIONS IN: aconitate hydratase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, isocitrate metabolic process, citrate metabolic process; LOCATED IN: cytosol, mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase-like core (InterPro:IPR015937), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 3 (TAIR:AT2G05710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Protein Annotations |
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Coordinates (TAIR10) | chr4:+:13543077..13548427 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight (calculated) | 108487.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IEP (calculated) | 7.16 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GRAVY (calculated) | -0.25 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Length | 995 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence (TAIR10) (BLAST) |
001: MYRRATSGVR SASARLSSSL SRIASSETAS VSAPSASSLR NQTNRSKSFS SALRSFRVCS ASTRWSHGGS WGSPASLRAQ ARNSTPVMEK FERKYATMAS 101: EHSYKDILTS LPKPGGGEYG KYYSLPALND PRIDKLPFSV RILLESAIRN CDNYQVTKDD VEKILDWENT STKQVEIAFK PARVILQDFT GVPVLVDLAS 201: MRDAVKNLGS DPSKINPLVP VDLVVDHSIQ VDFARSEDAA QKNLELEFKR NKERFTFLKW GSTAFQNMLV VPPGSGIVHQ VNLEYLGRVV FNSKGFLYPD 301: SVVGTDSHTT MIDGLGVAGW GVGGIEAEAA MLGQPMSMVL PGVVGFKLDG KLKEGVTATD LVLTVTQILR KHGVVGKFVE FYGEGMSELS LADRATIANM 401: SPEYGATMGF FPVDHVTLEY LKLTGRSDET VSMIESYLRA NNMFVDYNEP QQERAYTSYL QLDLGHVEPC ISGPKRPHDR VPLKDMKADW HACLDNPVGF 501: KGFAVPKEKQ EEVVKFSYNG QPAEIKHGSV VIAAITSCTN TSNPSVMIGA ALVAKKASDL GLKVKPWVKT SLAPGSRVVE KYLDRSGLRE SLTKQGFEIV 601: GYGCTTCIGN SGNLDPEVAS AIEGTDIIPA AVLSGNRNFE GRVHPQTRAN YLASPPLVVA YALAGTVDID FEKEPIGTRS DGKSVYLRDV WPSNEEVAQV 701: VQYSVLPSMF KSSYETITEG NPLWNELSAP SSTLYSWDPN STYIHEPPYF KNMTANPPGP REVKDAYCLL NFGDSVTTDH ISPAGNIQKT SPAAKFLMDR 801: GVISEDFNSY GSRRGNDEVM ARGTFANIRI VNKLLKGEVG PNTVHIPTGE KLSVFDAASK YKTAEQDTII LAGAEYGSGS SRDWAAKGPL LLGVKAVIAK 901: SFERIHRSNL AGMGIIPLCF KAGEDAETLG LTGHERYTVH LPTKVSDIRP GQDVTVTTDS GKSFVCTLRF DTEVELAYYD HGGILPYVIR SLSAK |
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See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)