AT5G55310.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : DNA topoisomerase 1 beta | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:-:22430389..22434590 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 103060.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 10.11 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.86 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 917 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MATEAFVKPV VPNGHDGYED EDEDDIPLVF KRNSNTAATT NRPSPINNAM RNSAIGSTKS SPPMRSPLTS PNRSASSSTR SSMMKPALPS SSSVQRSTLK 101: SPLRDDRSVV AKERNGFGKA PSVSKSDDED SEDDKPLSAR LKLDSKEVTK QPSSSGRGST QQAVQKSNMR PQGLSDYTKK KVLDERAPMS STVQTKTSVG 201: TSSSKPVHIE QKRPLVNNID RNGLKPKTEG HSSQAPAKRP LEKGSSSNQS SVKRPKLSEP ARPVKVEQGS HISATQDAKG KNLDASKPLR ANQATVKEDN 301: SDGDDHVPIA SRMKSDSSNN KSSSAKPSSS KMIASSSRTI AQKPNKWVKD SKYSKSSKSL PSGDGQKKWK TLQHNGVIFP PPYKRHGVKI LFQGKPVDLT 401: PEQEEVATMF AVMRETEYYK KPKFRENFWN DWRKLLGKNH MIKSLDDCDF TPIYEWYMQE KETKKQMTAE EKRIVKEEKL KQEEKYMWAV LDGVRERIGN 501: FRVEPPGLFR GRGEHPKMGK LKKRIRPCDI TINIGKEAPI PECPIPGERW KEVKHDNTVT WLAFWSDPIN PKEFKYVFLA ASSSLKGQSD KEKYEKARKL 601: HNHIGSIRAA YTKDFNNKDV TKRQIAVATY LIDKLALRAG NEKDDDEADT VGCCTLKVGN VECIPPNKLK FDFLGKDSIQ YVNTVEVEPL VYKAIGQFQA 701: GKSKTDDLFD ELDTSKLNTH LKELMAGLTA KVFRTYNASI TLDLMLSKET RDGDVPEKVV VYQQANKEVA IICNHQRTVS KSHGAQVEKL AVKIEELREQ 801: IKELNIDLDR AKKGRTPLMG SDGKRKRNLT PEALEKKIMQ TQGKIEKMER DMQTKEDMKT VALGTSKINY MDPRITVAWC KRHDVPIEKI FNKSLLAKFA 901: WAMDVDPEFR FCSSTDE |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)