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AT5G48000.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:23990937 (2013): plasma membrane
  • PMID:22923678 (2012): endoplasmic reticulum
  • PMID:16618929 (2006): endoplasmic reticulum
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : cytochrome P450, family 708, subfamily A, polypeptide 2
Curator
Summary (TAIR10)
Encodes a member of the CYP708A family of cytochrome P450 enzymes. THAH appears to add a hydroxyl group to the triterpene thalianol. thah1 mutants have an elevated accumulation of thalianol. thah1-1 mutants have longer roots than wild type plants. Thalian-diol and desaturated thalian-diol are lost from the root extracts of thah1-1 mutants. Overexpression of the sequence from At5g48000.1 rescues the thah1-1 mutant phenotype (Field 2008); it is unknown whether the shorter sequences associated with other gene models would provide functional complementation.
Computational
Description (TAIR10)
cytochrome P450, family 708, subfamily A, polypeptide 2 (CYP708A2); FUNCTIONS IN: thalianol hydroxylase activity, oxygen binding; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28765 Blast hits to 28695 proteins in 1599 species: Archae - 49; Bacteria - 5026; Metazoa - 10250; Fungi - 5008; Plants - 7191; Viruses - 6; Other Eukaryotes - 1235 (source: NCBI BLink).
Protein Annotations
eggNOG:COG2124eggNOG:KOG0157EMBL:CP002688EnsemblPlants:AT5G48000
EnsemblPlants:AT5G48000.1entrez:834851ExpressionAtlas:F4K051Gene3D:1.10.630.10
GeneID:834851GO:GO:0005506GO:GO:0005783GO:GO:0010268
GO:GO:0016021GO:GO:0016125GO:GO:0016132GO:GO:0016705
GO:GO:0020037GO:GO:0048364GO:GO:0080003GO:GO:0080014
Gramene:AT5G48000.1gramene_pathway:1.14.13.-gramene_pathway:PWY-5992hmmpanther:PTHR24286
hmmpanther:PTHR24286:SF37InterPro:IPR001128InterPro:IPR002403InterPro:IPR017972
OMA:RMANMAPPaxDb:F4K051Pfam:PF00067PRIDE:F4K051
PRINTS:PR00385PRINTS:PR00465PROSITE:PS00086ProteinModelPortal:F4K051
Proteomes:UP000006548RefSeq:NP_851152.1scanprosite:PS00086SMR:F4K051
STRING:3702.AT5G48000.1SUPFAM:SSF48264TAIR:AT5G48000tair10-symbols:CYP708 A2
tair10-symbols:CYP708A2tair10-symbols:THAHtair10-symbols:THAH1TMHMM:TMhelix
UniGene:At.26827UniProt:F4K051
Coordinates (TAIR10) chr5:-:19444313..19447790
Molecular Weight (calculated) 58880.80 Da
IEP (calculated) 9.51
GRAVY (calculated) -0.08
Length 518 amino acids
Sequence (TAIR10)
(BLAST)
001: MDRRGKYWAG PMWIGLSMCG SGSDTILECR LRLFKLQRQN QMSFVWSAAV WVIAVAAVVI SKWLYRWSNP KCNGKLPPGS MGLPIIGETC DFFEPHGLYE
101: ISPFVKKRML KYGPLFRTNI FGSNTVVLTE PDIIFEVFRQ ENKSFVFSYP EAFVKPFGKE NVFLKHGNIH KHVKQISLQH LGSEALKKKM IGEIDRVTYE
201: HLRSKANQGS FDAKEAVESV IMAHLTPKII SNLKPETQAT LVDNIMALGS EWFQSPLKLT TLISIYKVFI ARRYALQVIK DVFTRRKASR EMCGDFLDTM
301: VEEGEKEDVI FNEESAINLI FAILVVAKES TSSVTSLAIK FLAENHKALA ELKREHAAIL QNRNGKGAGV SWEEYRHQMT FTNMVINETL RMANMAPIMY
401: RKAVNDVEIK GYTIPAGWIV AVIPPAVHFN DAIYENPLEF NPWRWEGKEL RSGSKTFMVF GGGVRQCVGA EFARLQISIF IHHLVTTYDF SLAQESEFIR
501: APLPYFPKGL PIKISQSL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)