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AT5G45340.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:21515817 (2011): endoplasmic reticulum
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : cytochrome P450, family 707, subfamily A, polypeptide 3
Curator
Summary (TAIR10)
Encodes a protein with ABA 8'-hydroxylase activity; involved in ABA catabolism. Mutant analyses show that disruption in the gene results in more drought tolerance whereas overexpression results in increased transpiration rate and reduced drought tolerance. Gene involved in postgermination growth. Plant P450 CYP707A3, ABA 8'-hydroxylase, binds enantioselectively (+)-ABA but not (-)-ABA, whereas the enzyme binds both enantiomers of AHI1 (a structural ABA analogue used as ABA 8'-hydroxylase competitive inhibitor).
Computational
Description (TAIR10)
cytochrome P450, family 707, subfamily A, polypeptide 3 (CYP707A3); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 8 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 1 (TAIR:AT4G19230.1); Has 36672 Blast hits to 36553 proteins in 1858 species: Archae - 82; Bacteria - 8489; Metazoa - 11350; Fungi - 6268; Plants - 8323; Viruses - 6; Other Eukaryotes - 2154 (source: NCBI BLink).
Protein Annotations
BindingDB:Q9FH76BioCyc:ARA:AT5G45340-MONOMERBioCyc:ARA:GQT-1434-MONOMERBioCyc:MetaCyc:AT5G45340-MONOMER
BRENDA:1.14.13.93ChEMBL:CHEMBL4538EC:1.14.13.93eggNOG:COG2124
eggNOG:KOG0157EMBL:AB020744EMBL:AB122150EMBL:AY065065
EMBL:AY102136EMBL:CP002688EnsemblPlants:AT5G45340EnsemblPlants:AT5G45340.1
entrez:834570Gene3D:1.10.630.10GeneID:834570Genevisible:Q9FH76
GO:GO:0005506GO:GO:0007275GO:GO:0009414GO:GO:0009639
GO:GO:0010268GO:GO:0010295GO:GO:0016021GO:GO:0016125
GO:GO:0016132GO:GO:0020037GO:GO:0046345gramene_pathway:1.14.13.93
gramene_pathway:PWY-5271hmmpanther:PTHR24286hmmpanther:PTHR24286:SF10HOGENOM:HOG000237614
InterPro:IPR001128InterPro:IPR002401InterPro:IPR017972KEGG:ath:AT5G45340
KO:K09843OMA:HIESIAQPaxDb:Q9FH76Pfam:PF00067
Pfam:Q9FH76PhylomeDB:Q9FH76PRIDE:Q9FH76PRINTS:PR00385
PRINTS:PR00463PRO:PR:Q9FH76PROSITE:PS00086ProteinModelPortal:Q9FH76
Proteomes:UP000006548Reactome:R-ATH-211916Reactome:R-ATH-5365859RefSeq:NP_199347.2
RefSeq:NP_851136.1SABIO-RK:Q9FH76scanprosite:PS00086SMR:Q9FH76
STRING:3702.AT5G45340.1SUPFAM:SSF48264TAIR:AT5G45340tair10-symbols:CYP707A3
TMHMM:TMhelixUniGene:At.9625UniPathway:UPA00093UniProt:Q9FH76
Coordinates (TAIR10) chr5:-:18368977..18370909
Molecular Weight (calculated) 52369.50 Da
IEP (calculated) 9.23
GRAVY (calculated) -0.18
Length 463 amino acids
Sequence (TAIR10)
(BLAST)
001: MDFSGLFLTL SAAALFLCLL RFIAGVRRSS STKLPLPPGT MGYPYVGETF QLYSQDPNVF FAAKQRRYGS VFKTHVLGCP CVMISSPEAA KFVLVTKSHL
101: FKPTFPASKE RMLGKQAIFF HQGDYHSKLR KLVLRAFMPD AIRNMVPHIE SIAQESLNSW DGTQLNTYQE MKTYTFNVAL ISILGKDEVY YREDLKRCYY
201: ILEKGYNSMP INLPGTLFHK AMKARKELAQ ILANILSKRR QNPSSHTDLL GSFMEDKAGL TDEQIADNII GVIFAARDTT ASVLTWILKY LADNPTVLEA
301: VTEEQMAIRK DKKEGESLTW EDTKKMPLTY RVIQETLRAA TILSFTFREA VEDVEYEGYL IPKGWKVLPL FRNIHHNADI FSDPGKFDPS RFEVAPKPNT
401: FMPFGSGIHS CPGNELAKLE ISVLIHHLTT KYRWSIVGPS DGIQYGPFAL PQNGLPIALE RKP
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)