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AT4G34580.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plasma membrane 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Sec14p-like phosphatidylinositol transfer family protein
Curator
Summary (TAIR10)
Encodes COW1 (can of worms1), a phosphatidylinositol transfer protein essential for root hair tip growth. The N-terminus of the COW1 protein is 32% identical to an essential phosphatidylinositol transfer protein (PITP), the yeast Sec14 protein (sec14p) while the C-terminus is 34.5% identical to a late nodulin of Lotus japonicus, Nlj16. Expression of COW1 complements the growth defect associated with Sec14p dysfunction in yeast. GFP fused to the COW1 protein specifically accumulates at the site of root hair outgrowth.
Computational
Description (TAIR10)
CAN OF WORMS1 (COW1); FUNCTIONS IN: transporter activity, phosphatidylinositol transporter activity; INVOLVED IN: root epidermal cell differentiation, transport, root hair cell tip growth, cell tip growth; LOCATED IN: intracellular; EXPRESSED IN: 9 plant structures; CONTAINS InterPro DOMAIN/s: Cellular retinaldehyde-binding/triple function, C-terminal (InterPro:IPR001251), Cellular retinaldehyde-binding/triple function, N-terminal (InterPro:IPR008273), Cellular retinaldehyde binding/alpha-tocopherol transport (InterPro:IPR001071), Phosphatidylinositol transfer protein-like, N-terminal (InterPro:IPR011074); BEST Arabidopsis thaliana protein match is: Sec14p-like phosphatidylinositol transfer family protein (TAIR:AT2G16380.1); Has 3006 Blast hits to 2988 proteins in 244 species: Archae - 0; Bacteria - 0; Metazoa - 982; Fungi - 671; Plants - 907; Viruses - 0; Other Eukaryotes - 446 (source: NCBI BLink).
Protein Annotations
eggNOG:ENOG410XRSQeggNOG:KOG1471EMBL:AJ616026EMBL:AJ616027
EMBL:AL023094EMBL:AL161585EMBL:CP002687EnsemblPlants:AT4G34580
EnsemblPlants:AT4G34580.1entrez:829610Gene3D:3.40.525.10GeneID:829610
Genevisible:F4JLE5GO:GO:0000139GO:GO:0005215GO:GO:0005886
GO:GO:0009932GO:GO:0010053GO:GO:0015031GO:GO:0035619
GO:GO:0048767GO:GO:0048768Gramene:AT4G34580.1hmmpanther:PTHR23324
hmmpanther:PTHR23324:SF77HOGENOM:HOG000196557InParanoid:F4JLE5InterPro:IPR001071
InterPro:IPR001251InterPro:IPR011074iPTMnet:F4JLE5KEGG:ath:AT4G34580
ncoils:CoilOMA:PISEDEHPaxDb:F4JLE5Pfam:F4JLE5
Pfam:PF00650Pfam:PF03765Pfscan:PS50191PIR:T05278
PRIDE:F4JLE5PRINTS:PR00180PRO:PR:F4JLE5PROSITE:PS50191
ProteinModelPortal:F4JLE5Proteomes:UP000006548RefSeq:NP_195184.2SMART:SM00516
SMART:SM01100SMR:F4JLE5STRING:3702.AT4G34580.1SUPFAM:SSF46938
SUPFAM:SSF52087TAIR:AT4G34580tair10-symbols:COW1tair10-symbols:SRH1
UniGene:At.31489UniProt:F4JLE5
Coordinates (TAIR10) chr4:+:16515422..16518527
Molecular Weight (calculated) 63290.40 Da
IEP (calculated) 8.43
GRAVY (calculated) -0.53
Length 554 amino acids
Sequence (TAIR10)
(BLAST)
001: MAETKPEIEM SEEERKIVKI SSLKKKAINA SNRFKNSFKK KGRRSSSRVM SVPIEDDIDA EDLQALDAFR QALILDELLP SKLDDLHMML RFLRARKFDI
101: EKAKQMWSDM IQWRKDFGAD TIIEDFDFEE IDEVMKHYPQ GYHGVDKEGR PVYIERLGQI DANKLLQVTT MDRYVKYHVK EFEKTFKVKF PSCSVAANKH
201: IDQSTTILDV QGVGLKNFSK SARELLQRLC KIDNENYPET LNRMFIINAG SGFRLLWSTV KSFLDPKTTA KIHVLGNKYH SKLLEVIDAS ELPEFFGGAC
301: TCEDKGGCMR SDKGPWNDPE VLKIAINREA KCSPISEDEH KHVDQGRSTS GFESLERIKK KTDEDNVYEK QIATIDKSMD MAWLAKTQKA ENFPISKGLE
401: CYVRKGAPKK GDGLLVGGVM AFVMGIVAMV RLSKDVPRKL TEAALYGNSV CYEESTKSKQ NQGQFAAPVS SSEYMLMVKR MAELEDKCMF LDLKPAHVES
501: EKEEKLQAAL NRVQVLEQEL TETKKALEEA LVSQKEILAY IEKKKKKKKL FFGF
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)