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AT3G13170.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no coexpression data
Description (TAIR10) protein_coding : Spo11/DNA topoisomerase VI, subunit A protein
Curator
Summary (TAIR10)
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.
Computational
Description (TAIR10)
ATSPO11-1; CONTAINS InterPro DOMAIN/s: Spo11/DNA topoisomerase VI, subunit A, N-terminal (InterPro:IPR013049), Meiotic recombination, Spo11 (InterPro:IPR013048), Spo11/DNA topoisomerase VI, subunit A (InterPro:IPR002815); BEST Arabidopsis thaliana protein match is: Spo11/DNA topoisomerase VI, subunit A protein (TAIR:AT5G02820.1); Has 908 Blast hits to 908 proteins in 313 species: Archae - 216; Bacteria - 16; Metazoa - 170; Fungi - 122; Plants - 151; Viruses - 0; Other Eukaryotes - 233 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:GQT-2289-MONOMEREC:5.99.1.3eggNOG:COG1697eggNOG:KOG2795
EMBL:AF302928EMBL:AJ251989EMBL:AP000375EMBL:BT028955
EMBL:CP002686EnsemblPlants:AT3G13170EnsemblPlants:AT3G13170.1entrez:820506
Gene3D:1.10.10.10GeneID:820506Genevisible:Q9M4A2GO:GO:0000737
GO:GO:0003677GO:GO:0005524GO:GO:0005634GO:GO:0005694
GO:GO:0007129GO:GO:0007131GO:GO:0016787GO:GO:0042138
GO:GO:0046872GO:GO:0051026hmmpanther:PTHR10848hmmpanther:PTHR10848:SF3
HOGENOM:HOG000225930IntAct:Q9M4A2InterPro:IPR002815InterPro:IPR011991
InterPro:IPR013048InterPro:IPR013049KEGG:ath:AT3G13170KO:K10878
MINT:MINT-5222860OMA:LANDMFCPANTHER:PTHR10848PaxDb:Q9M4A2
Pfam:PF04406Pfam:Q9M4A2PhylomeDB:Q9M4A2PIR:T52652
PRIDE:Q9M4A2PRINTS:PR01550PRINTS:PR01551PRO:PR:Q9M4A2
ProteinModelPortal:Q9M4A2Proteomes:UP000006548RefSeq:NP_187923.1SMR:Q9M4A2
STRING:3702.AT3G13170.1SUPFAM:0036260SUPFAM:SSF56726TAIR:AT3G13170
tair10-symbols:ATSPO11-1UniGene:At.48652UniProt:Q9M4A2
Coordinates (TAIR10) chr3:-:4231560..4234192
Molecular Weight (calculated) 41806.10 Da
IEP (calculated) 7.80
GRAVY (calculated) -0.15
Length 362 amino acids
Sequence (TAIR10)
(BLAST)
001: MEGKFAISES TNLLQRIKDF TQSVVVDLAE GRSPKISINQ FRNYCMNPEA DCLCSSDKPK GQEIFTLKKE PQTYRIDMLL RVLLIVQQLL QENRHASKRD
101: IYYMHPSAFK AQSIVDRAIG DICILFQCSR YNLNVVSVGN GLVMGWLKFR EAGRKFDCLN SLNTAYPVPV LVEEVEDIVS LAEYILVVEK ETVFQRLAND
201: MFCKTNRCIV ITGRGYPDVS TRRFLRLLME KLHLPVHCLV DCDPYGFEIL ATYRFGSMQM AYDIESLRAP DMKWLGAFPS DSEVYSVPKQ CLLPLTEEDK
301: KRTEAMLLRC YLKREMPQWR LELETMLKRG VKFEIEALSV HSLSFLSEVY IPSKIRREVS SP
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)