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AT1G63990.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no coexpression data
Description (TAIR10) protein_coding : sporulation 11-2
Curator
Summary (TAIR10)
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
Computational
Description (TAIR10)
sporulation 11-2 (SPO11-2); FUNCTIONS IN: DNA topoisomerase (ATP-hydrolyzing) activity, DNA binding, catalytic activity, ATP binding; INVOLVED IN: in 11 processes; LOCATED IN: chromosome; CONTAINS InterPro DOMAIN/s: Spo11/DNA topoisomerase VI, subunit A, N-terminal (InterPro:IPR013049), Spo11/DNA topoisomerase VI, subunit A (InterPro:IPR002815); BEST Arabidopsis thaliana protein match is: Spo11/DNA topoisomerase VI, subunit A protein (TAIR:AT5G02820.1); Has 890 Blast hits to 889 proteins in 304 species: Archae - 214; Bacteria - 14; Metazoa - 169; Fungi - 107; Plants - 162; Viruses - 0; Other Eukaryotes - 224 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:GQT-2072-MONOMEREC:5.99.1.3eggNOG:COG1697eggNOG:KOG2795
EMBL:AC007764EMBL:AJ251990EMBL:CP002684EMBL:DQ446392
EnsemblPlants:AT1G63990EnsemblPlants:AT1G63990.1entrez:842702Gene3D:1.10.10.10
GeneID:842702Genevisible:Q9M4A1GO:GO:0000737GO:GO:0003677
GO:GO:0005524GO:GO:0005634GO:GO:0005694GO:GO:0007126
GO:GO:0009553GO:GO:0009555GO:GO:0016787GO:GO:0046872
GO:GO:0048316GO:GO:0051026Gramene:AT1G63990.1hmmpanther:PTHR10848
hmmpanther:PTHR10848:SF1HOGENOM:HOG000084591InParanoid:Q9M4A1IntAct:Q9M4A1
InterPro:IPR002815InterPro:IPR011991InterPro:IPR013049iPTMnet:Q9M4A1
KEGG:ath:AT1G63990KO:K10878OMA:RSLMRPNPANTHER:PTHR10848
PaxDb:Q9M4A1Pfam:PF04406Pfam:Q9M4A1PhylomeDB:Q9M4A1
PIR:A96665PIR:T52651PRIDE:Q9M4A1PRINTS:PR01550
PRO:PR:Q9M4A1ProteinModelPortal:Q9M4A1Proteomes:UP000006548RefSeq:NP_176582.2
SMR:Q9M4A1STRING:3702.AT1G63990.1SUPFAM:0036260SUPFAM:SSF56726
TAIR:AT1G63990tair10-symbols:SPO11-2UniGene:At.48342UniProt:Q9M4A1
Coordinates (TAIR10) chr1:-:23743323..23745351
Molecular Weight (calculated) 43128.60 Da
IEP (calculated) 8.39
GRAVY (calculated) 0.09
Length 383 amino acids
Sequence (TAIR10)
(BLAST)
001: MEESSGLSSM KFFSDQHLSY ADILLPHEAR ARIEVSVLNL LRILNSPDPA ISDLSLINRK RSNSCINKGI LTDVSYIFLS TSFTKSSLTN AKTAKAFVRV
101: WKVMEICFQI LLQEKRVTQR ELFYKLLCDS PDYFSSQIEV NRSVQDVVAL LRCSRYSLGI MASSRGLVAG RLFLQEPGKE AVDCSACGSS GFAITGDLNL
201: LDNTIMRTDA RYIIIVEKHA IFHRLVEDRV FNHIPCVFIT AKGYPDIATR FFLHRMSTTF PDLPILVLVD WNPAGLAILC TFKFGSIGMG LEAYRYACNV
301: KWIGLRGDDL NLIPEESLVP LKPKDSQIAK SLLSSKILQE NYIEELSLMV QTGKRAEIEA LYCHGYNYLG KYIATKIVQG KYI
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)