AT2G29630.1
Subcellular Consensus
(Prediction and Experimental) min: :max .
SUBAcon:plastid 1.000 What is SUBAcon? |
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Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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Description (TAIR10) | protein_coding : thiaminC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Curator Summary (TAIR10) |
Encodes a protein involved in thiamine biosynthesis. The protein is an iron-sulfur cluster protein predicted to catalyze the conversion of 5-aminoimidazole ribonucleotide (AIR) to hydroxymethylpyrimidine phosphate (HMP-P). A severe reduction of THIC levels in plants decreases vitamin B1 (thiamin diphosphate (TPP)) levels and also leads to changes in the levels of numerous other metabolites since so many primary metabolic enzymes require a TPP co-factor. thiC mutants are chlorotic and arrest in their development at the cotyledon stage. A N-terminal targeting sequence directs the THIC protein to the chloroplast stroma. The THIC transcript is regulated by a TPP riboswitch in the 3' UTR. THIC transcripts are observed in seedlings 5 or more days after germination, and light promotes the expression of this gene. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Computational Description (TAIR10) |
thiaminC (THIC); FUNCTIONS IN: iron-sulfur cluster binding, catalytic activity, ADP-ribose pyrophosphohydrolase activity; INVOLVED IN: response to vitamin B1, detection of bacterium, thiamin biosynthetic process; LOCATED IN: chloroplast, chloroplast stroma, plastid; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine biosynthesis protein ThiC (InterPro:IPR002817); Has 4416 Blast hits to 4411 proteins in 1719 species: Archae - 238; Bacteria - 3466; Metazoa - 3; Fungi - 0; Plants - 61; Viruses - 0; Other Eukaryotes - 648 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Protein Annotations |
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Coordinates (TAIR10) | chr2:+:12667395..12669569 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight (calculated) | 71990.50 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IEP (calculated) | 6.41 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GRAVY (calculated) | -0.41 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Length | 644 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence (TAIR10) (BLAST) |
001: MAASVHCTLM SVVCNNKNHS ARPKLPNSSL LPGFDVVVQA AATRFKKETT TTRATLTFDP PTTNSERAKQ RKHTIDPSSP DFQPIPSFEE CFPKSTKEHK 101: EVVHEESGHV LKVPFRRVHL SGGEPAFDNY DTSGPQNVNA HIGLAKLRKE WIDRREKLGT PRYTQMYYAK QGIITEEMLY CATREKLDPE FVRSEVARGR 201: AIIPSNKKHL ELEPMIVGRK FLVKVNANIG NSAVASSIEE EVYKVQWATM WGADTIMDLS TGRHIHETRE WILRNSAVPV GTVPIYQALE KVDGIAENLN 301: WEVFRETLIE QAEQGVDYFT IHAGVLLRYI PLTAKRLTGI VSRGGSIHAK WCLAYHKENF AYEHWDDILD ICNQYDVALS IGDGLRPGSI YDANDTAQFA 401: ELLTQGELTR RAWEKDVQVM NEGPGHVPMH KIPENMQKQL EWCNEAPFYT LGPLTTDIAP GYDHITSAIG AANIGALGTA LLCYVTPKEH LGLPNRDDVK 501: AGVIAYKIAA HAADLAKQHP HAQAWDDALS KARFEFRWMD QFALSLDPMT AMSFHDETLP ADGAKVAHFC SMCGPKFCSM KITEDIRKYA EENGYGSAEE 601: AIRQGMDAMS EEFNIAKKTI SGEQHGEVGG EIYLPESYVK AAQK |
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See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)