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AT1G02580.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no coexpression data
Description (TAIR10) protein_coding : SET domain-containing protein
Curator
Summary (TAIR10)
Encodes a putative transcription factor MEDEA (MEA) that negatively regulates seed development in the absence of fertilization. Mutations in this locus result in embryo lethality. MEA is a Polycomb group gene that is imprinted in the endosperm. The maternal allele is expressed and the paternal allele is silent. MEA is controlled by DEMETER (DME), a DNA glycosylase required to activate MEA expression, and METHYLTRANSFERASE I (MET1), which maintains CG methylation at the MEA locus. MEA is involved in the negative regulation of its own imprinted gene expression; the effect is not only allele-specific but also dynamically regulated during seed development. In the ovule, the MEA transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization
Computational
Description (TAIR10)
MEDEA (MEA); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), SET domain (InterPro:IPR001214); BEST Arabidopsis thaliana protein match is: SET domain-containing protein (TAIR:AT4G02020.1); Has 4870 Blast hits to 4762 proteins in 465 species: Archae - 0; Bacteria - 401; Metazoa - 1924; Fungi - 484; Plants - 1009; Viruses - 0; Other Eukaryotes - 1052 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT1G02580-MONOMERBioGrid:24657EC:2.1.1.43eggNOG:COG2940
eggNOG:KOG1079EMBL:AC022521EMBL:AF060485EMBL:AF096094
EMBL:CP002684EnsemblPlants:AT1G02580EnsemblPlants:AT1G02580.1entrez:839422
GeneID:839422Genevisible:O65312GO:GO:0003700GO:GO:0005634
GO:GO:0006349GO:GO:0006351GO:GO:0009646GO:GO:0018024
GO:GO:0031519GO:GO:0043565GO:GO:0045892GO:GO:0048317
GO:GO:2000014Gramene:AT1G02580.1hmmpanther:PTHR22884hmmpanther:PTHR22884:SF326
HOGENOM:HOG000083511IntAct:O65312InterPro:IPR001214InterPro:IPR025778
InterPro:IPR026489InterPro:IPR033467KEGG:ath:AT1G02580KO:K11430
ncoils:CoilOMA:NCYAKLMPaxDb:O65312Pfam:O65312
Pfam:PF00856Pfscan:PS50280Pfscan:PS51576Pfscan:PS51633
PhylomeDB:O65312PIR:T52060PRIDE:O65312PRO:PR:O65312
PROSITE:PS50280PROSITE:PS51576PROSITE:PS51633ProteinModelPortal:O65312
Proteomes:UP000006548RefSeq:NP_563658.1SMART:SM00317SMART:SM01114
SMR:O65312STRING:3702.AT1G02580.1SUPFAM:SSF82199TAIR:AT1G02580
tair10-symbols:EMB173tair10-symbols:FIS1tair10-symbols:MEAtair10-symbols:SDG5
UniGene:At.10786UniProt:O65312
Coordinates (TAIR10) chr1:+:544796..548994
Molecular Weight (calculated) 79313.80 Da
IEP (calculated) 5.19
GRAVY (calculated) -0.84
Length 689 amino acids
Sequence (TAIR10)
(BLAST)
001: MEKENHEDDG EGLPPELNQI KEQIEKERFL HIKRKFELRY IPSVATHASH HQSFDLNQPA AEDDNGGDNK SLLSRMQNPL RHFSASSDYN SYEDQGYVLD
101: EDQDYALEED VPLFLDEDVP LLPSVKLPIV EKLPRSITWV FTKSSQLMAE SDSVIGKRQI YYLNGEALEL SSEEDEEDEE EDEEEIKKEK CEFSEDVDRF
201: IWTVGQDYGL DDLVVRRALA KYLEVDVSDI LERYNELKLK NDGTAGEASD LTSKTITTAF QDFADRRHCR RCMIFDCHMH EKYEPESRSS EDKSSLFEDE
301: DRQPCSEHCY LKVRSVTEAD HVMDNDNSIS NKIVVSDPNN TMWTPVEKDL YLKGIEIFGR NSCDVALNIL RGLKTCLEIY NYMREQDQCT MSLDLNKTTQ
401: RHNQVTKKVS RKSSRSVRKK SRLRKYARYP PALKKTTSGE AKFYKHYTPC TCKSKCGQQC PCLTHENCCE KYCGCSKDCN NRFGGCNCAI GQCTNRQCPC
501: FAANRECDPD LCRSCPLSCG DGTLGETPVQ IQCKNMQFLL QTNKKILIGK SDVHGWGAFT WDSLKKNEYL GEYTGELITH DEANERGRIE DRIGSSYLFT
601: LNDQLEIDAR RKGNEFKFLN HSARPNCYAK LMIVRGDQRI GLFAERAIEE GEELFFDYCY GPEHADWSRG REPRKTGASK RSKEARPAR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)