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AT2G45140.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
endoplasmic reticulum 1.000
ASURE: endoplasmic reticulum
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:27159525 (2016): endoplasmic reticulum
  • PMID:27159525 (2016): plasma membrane
  • PMID:32219438 (2020): cytosol
  • PMID:31615849 (2019): plastid plastid thylakoid
  • PMID:31520498 (2020): mitochondrion
  • PMID:26572690 (2016): extracellular region plant-type cell wall
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:22550958 (2012): plastid
  • PMID:22215637 (2012): plasma membrane
  • PMID:18433157 (2008): cytosol
  • PMID:18433157 (2008): nucleus
  • PMID:17644812 (2007): plasma membrane
  • PMID:17317660 (2007): plasma membrane
  • PMID:16618929 (2006): endoplasmic reticulum
  • PMID:15308754 (2004): plasma membrane
  • PMID:14506206 (2003): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : plant VAP homolog 12
Curator
Summary (TAIR10)
Encodes a Plant VAMP-Associated protein that localizes to the ER and binds to the sitosterol-binding protein ORP3a. The WFDE motif in ORP3a appears to be important for this direct interaction. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
Computational
Description (TAIR10)
plant VAP homolog 12 (PVA12); FUNCTIONS IN: structural molecule activity; LOCATED IN: cytosol, endoplasmic reticulum, nucleus, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: vesicle associated protein (TAIR:AT3G60600.1); Has 1106 Blast hits to 1079 proteins in 208 species: Archae - 0; Bacteria - 0; Metazoa - 441; Fungi - 140; Plants - 434; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).
Protein Annotations
BioGrid:4458eggNOG:COG5066eggNOG:KOG0439EMBL:AY088399
EMBL:AY093014EMBL:BT006283EMBL:CP002685EnsemblPlants:AT2G45140
EnsemblPlants:AT2G45140.1entrez:819122Gene3D:2.60.40.360GeneID:819122
Genevisible:Q9SHC8GO:GO:0005634GO:GO:0005783GO:GO:0005789
GO:GO:0005829GO:GO:0005886GO:GO:0006605GO:GO:0016021
Gramene:AT2G45140.1hmmpanther:PTHR10809hmmpanther:PTHR10809:SF50HOGENOM:HOG000188310
InParanoid:Q9SHC8IntAct:Q9SHC8InterPro:IPR000535InterPro:IPR008962
InterPro:IPR016763iPTMnet:Q9SHC8KEGG:ath:AT2G45140ncoils:Coil
OMA:YSANTSQPANTHER:PTHR10809PaxDb:Q9SHC8Pfam:PF00635
Pfam:Q9SHC8Pfscan:PS50202PhylomeDB:Q9SHC8PIR:H84886
PIRSF:PIRSF019693PRIDE:Q9SHC8PRO:PR:Q9SHC8PROSITE:PS50202
ProteinModelPortal:Q9SHC8Proteomes:UP000006548RefSeq:NP_182039.1SMR:Q9SHC8
STRING:3702.AT2G45140.1SUPFAM:SSF49354TAIR:AT2G45140tair10-symbols:PVA12
TMHMM:TMhelixUniGene:At.27608UniProt:Q9SHC8
Coordinates (TAIR10) chr2:+:18611029..18612971
Molecular Weight (calculated) 26443.60 Da
IEP (calculated) 9.14
GRAVY (calculated) -0.47
Length 239 amino acids
Sequence (TAIR10)
(BLAST)
001: MSNELLTIDP VDLQFPFELK KQISCSLYLG NKTDNYVAFK VKTTNPKKYC VRPNTGVVHP RSSSEVLVTM QAQKEAPADL QCKDKFLLQC VVASPGATPK
101: DVTHEMFSKE AGHRVEETKL RVVYVAPPRP PSPVREGSEE GSSPRASVSD NGNASDFTAA PRFSADRVDA QDNSSEARAL VTKLTEEKNS AVQLNNRLQQ
201: ELDQLRRESK RSKSGGIPFM YVLLVGLIGL ILGYIMKRT
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)