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AT2G27120.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DNA polymerase epsilon catalytic subunit
Curator
Summary (TAIR10)
Encodes a protein with similarity to DNA polymerase epsilon catalytic subunit. Based on yeast two hybrid analysis, not predicted to be a subunit of the DNA polymerase epsilon complex. No phenotype observed in homozygous mutant embryos or plants but in combination with TIL1-1/til1-1 heterozygotes arrest earlier than til1 homozygotes suggesting TIL2 functions redundantly with TIL1.
Computational
Description (TAIR10)
TILTED 2 (TIL2); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: DNA replication; EXPRESSED IN: leaf whorl, sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT1G08260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
Protein Annotations
EC:2.7.7.7eggNOG:COG0417eggNOG:KOG1798EMBL:AC005623EMBL:CP002685EnsemblPlants:AT2G27120EnsemblPlants:AT2G27120.1
entrez:817254Gene3D:3.30.420.10GeneID:817254Genevisible:F4IFN6GO:GO:0000166GO:GO:0003677GO:GO:0003887
GO:GO:0006260GO:GO:0008270GO:GO:0008408GO:GO:0008622GO:GO:0051539Gramene:AT2G27120.1hmmpanther:PTHR10670
InParanoid:F4IFN6InterPro:IPR006133InterPro:IPR006134InterPro:IPR006172InterPro:IPR012337InterPro:IPR013697InterPro:IPR029703
iPTMnet:F4IFN6KEGG:00230+2.7.7.7KEGG:00240+2.7.7.7KEGG:ath:AT2G27120KO:K02324ncoils:CoilOMA:RITTTEC
PANTHER:PTHR10670PaxDb:F4IFN6Pfam:F4IFN6Pfam:PF00136Pfam:PF03104Pfam:PF08490PIR:A84669
PRIDE:F4IFN6PRO:PR:F4IFN6ProteinModelPortal:F4IFN6Proteomes:UP000006548Reactome:R-ATH-174430Reactome:R-ATH-68952Reactome:R-ATH-68962
RefSeq:NP_180280.2SMART:SM00486SMART:SM01159STRING:3702.AT2G27120.1SUPFAM:SSF53098SUPFAM:SSF56672TAIR:AT2G27120
tair10-symbols:POL2Btair10-symbols:TIL2UniGene:At.52932UniProt:F4IFN6
Coordinates (TAIR10) chr2:+:11581223..11594346
Molecular Weight (calculated) 245006.00 Da
IEP (calculated) 6.88
GRAVY (calculated) -0.32
Length 2138 amino acids
Sequence (TAIR10)
(BLAST)
0001: MSGRRCDRRL NVQKVSAADE LETKLGFGLF SQGETRLGWL LTFASSSWED ADTGKTFSCV DLFFVTQDGS SFKTKYKFRP YLYAATKDNM ELEVEAYLRR
0101: RYERQVADIQ IVHKEDLYLK NHLSGLQKKY LKVSFDTVQQ LVEVKRDLLH IVERNLAKFN ALEAYESILS GKREQRPQDC LDSVVDLREY DVPYHVRFAI
0201: DNDVRSGQWY NVSISSTDVI LEKRTDLLQR AEVRVCAFDI ETVKLPLKFP DAEYDQIMMI SYMVDGQGFL ITNRECVGKD IEDLEYTPKP EFEGYFKVTN
0301: VTNEVELLRK WFSHMQELKP GIYVTYNGDF FDWPFIERRA SHHGIKMNEE LGFRCDQNQG ECRAKFVCHL DCFSWVKRDS YLPQGSQGLK AVTKVKLGYD
0401: PLEVNPEDMV RFAMEKPQTM ASYSVSDAVA TYYLYMTYVH PFVFSLATII PMVPDEVLRK GSGTLCEMLL MVEAYKANVV CPNKNQADPE KFYQGKLLES
0501: ETYIGGHVEC LQSGVFRSDI PTSFKLDASA YQQLIDNLGR DLEYAITVEG KMRMDSVSNF DEVKEVIREK LEKLRDDPIR EEGPLIYHLD VAAMYPNIIL
0601: TNRLQPPSIV TDEVCTACDF NGPEKTCLRK LEWVWRGVTF KGNKSEYYHL KKQIESESVD AGANMQSSKP FLDLPKVEQQ SKLKERLKKY CQKAYSRVLD
0701: KPITEVREAG ICMRENPFYV DTVRSFRDRR YEYKTLNKVW KGKLSEAKAS GNLIKIQEAH DMVVVYDSLQ LAHKCILNSF YGYVMRKGAR WYSMEMAGVV
0801: TYTGAKIIQN ARLLIERIGK PLELDTDGIW CALPGSFPEN FTFKTIDMKK FTISYPCVIL NVDVAKNNSN DQYQTLVDPV RKTYNSRSEC SIEFEVDGPY
0901: KAMIIPASKE EGILIKKRYA VFNHDGTIAE LKGFEMKRRG ELKLIKVFQA ELFDKFLHGS TLEECYSAVA AVANRWLDLL EGQGKDIADS ELLDYISESS
1001: TMSKSLADYG QQKSCAVTTA KRLADFLGDT MVKDKGLRCQ YIVAREPEGT PVSERAVPVA IFQTDDPEKK FYLQKWCKIS SYTGIRSIID WMYYKQRLHS
1101: AIQKVITIPA AMQKVANPVL RVRHPYWLEK KVCDKFRQGK IVDMFSSANK DHSTTQDNVV ADIEEFCKEN RPSVKGPKPV ARSFEVDRNH SEGKQQESWD
1201: PEFHDISLQN VDKNVDYQGW LELEKRKWKM TLTNKKKRRY SSSLFGFDLE QNINKKVCKG RVGVGSYFRR PEEALTSSYL QIIQLVQSPQ SGQFFAWVVV
1301: EGLMLKIPLT IPRVFYINSK ASIAGNFTGK CINKILPHGK PCYNLMEVNI QEDQFIKESK KLAALLADPE IEGIYETKMP LEFSAICQIG CVCKIEDTAK
1401: HRNTQDGWKL GELHRITTTE CRYLENSIPL VYLYHSTSTG RAVYVLYCHA SKLMSVVVVN PYGDKELLSS ALERQFRDRC QELSPEPFSW DGILFQVEYV
1501: DHPEAATKFL QKALCEYREE NCGATVAVIE CPDFNTTKEG VKALEDFPCV RIPFNDDDNS YQPVSWQRPA AKIAVLRCAS AIQWLDRRIA QSRYAHVPLG
1601: NFGRDWLTFT VDIFLSRALR DQQQVLWVSD NGVPDLGDIN NEETFLADET SLLFPGAYRK VSVELKVHRL AVNALLKSDL VSEMEGGGFL GVNSRGSSLN
1701: DNGSFDENNG CAQAFRVLKQ LIKRLLHDAC NSGNIYADSI LQHLSWWLRS PSSKLHDPAL HLMLHKVMQK VFALLLTDLR RLGAIIIYAD FSKVIIDTGK
1801: FDLSAAKTYC ESLLTVMGSR DIFKLILLEP VHYWHSLLFM DQHNYAGIRA TGDEISGNEV TIEPKWSVAR HLPEYIQKDF IIIVATFIFG PWKFALEKKR
1901: GSAESLEAEM VEYLKEQIGT RFISMIVEKI GNIRSHIKDI NVSDASWASG QAPKGDYTFE FIQIITAVLA LDQNVQQDVL VMRKILLKYI KVKECAAEAE
2001: FIDPGPSFIL PNVACSNCGA YRDLDFCRDS ALLTEKEWSC ADPQCVKIYD KEQIESSIIQ MVRQRERMYQ LQDLVCNRCN QVKAAHLTEQ CECSGSFRCK
2101: ESGSDFHKRI EIFLDIAKRQ KFRLLEECIS WILFATSC
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)